{"id":53591,"date":"2025-03-27T08:11:49","date_gmt":"2025-03-27T00:11:49","guid":{"rendered":"https:\/\/www.chemhui.com\/?p=53591"},"modified":"2025-03-18T10:14:09","modified_gmt":"2025-03-18T02:14:09","slug":"angew-%e5%85%89%e6%b0%a7%e5%8c%96%e8%bf%98%e5%8e%9f%e5%82%ac%e5%8c%96%e4%bd%8d%e7%82%b9%e9%80%89%e6%8b%a9%e6%80%a7%e6%9e%84%e5%bb%ba-n-%e8%bf%9e%e6%8e%a5%e7%b3%96%e8%82%bd","status":"publish","type":"post","link":"http:\/\/www.chemhui.com\/angew-%e5%85%89%e6%b0%a7%e5%8c%96%e8%bf%98%e5%8e%9f%e5%82%ac%e5%8c%96%e4%bd%8d%e7%82%b9%e9%80%89%e6%8b%a9%e6%80%a7%e6%9e%84%e5%bb%ba-n-%e8%bf%9e%e6%8e%a5%e7%b3%96%e8%82%bd\/","title":{"rendered":"Angew. | \u5149\u6c27\u5316\u8fd8\u539f\u50ac\u5316\u4f4d\u70b9\u9009\u62e9\u6027\u6784\u5efa N-\u8fde\u63a5\u7cd6\u80bd"},"content":{"rendered":"<p>\u5206\u4eab\u7684\u662f\u4e00\u7bc7\u53d1\u8868\u5728 Angewandte Chemie International Edition \u4e0a\u7684\u6587\u7ae0\uff0c\u6807\u9898\u662f\u201cSite-Selective Construction of\u00a0<em>N<\/em>-Linked Glycopeptides through Photoredox Catalysis\u201d\uff0c\u6587\u7ae0\u7684\u901a\u8baf\u4f5c\u8005\u662f\u6765\u81ea\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u7684\u738b\u5e73\u6559\u6388\uff0c\u4ed6\u7684\u8bfe\u9898\u7ec4\u4e3b\u8981\u4ece\u4e8b\u5316\u5b66\u5408\u6210\u5177\u6709\u91cd\u8981\u751f\u7406\u6d3b\u6027\u7684\u7cd6\u86cb\u767d\u548c\u7cd6\u80bd\u3001\u7cd6\u7c7b\u5206\u5b50\u5408\u6210\u53ca\u5176\u65b9\u6cd5\u5b66\u7814\u7a76\u4ee5\u53ca\u591a\u80bd\u5408\u6210\u65b9\u6cd5\u5b66\u7814\u7a76\u3002<\/p>\n<section><img decoding=\"async\" title=\"1\" src=\"https:\/\/17332.seohost.cn\/storage\/17332\/article\/20250318\/1742263973403211.jpg\" alt=\"1\" \/><\/section>\n<section>\u86cb\u767d\u8d28\u7cd6\u57fa\u5316\u662f\u4e00\u79cd\u91cd\u8981\u7684\u7ffb\u8bd1\u540e\u4fee\u9970\uff0c\u5bf9\u4e8e\u5bbf\u4e3b\u4e0e\u75c5\u539f\u4f53\u76f8\u4e92\u4f5c\u7528\u3001\u8c03\u8282\u514d\u75ab\u53cd\u5e94\u3001\u4fc3\u8fdb<span class=\"\">\u86cb\u767d\u8d28\u6298\u53e0<\/span>\u548c\u7ef4\u6301\u86cb\u767d\u8d28\u7684\u7a33\u5b9a\u6027\u81f3\u5173\u91cd\u8981\u3002\u5728\u4e0d\u540c\u7c7b\u578b\u7684\u805a\u7cd6\u4e2d\uff0cN-\u805a\u7cd6\u662f\u4e00\u79cd\u5e7f\u6cdb\u4e14\u4fdd\u5b88\u7684\u7ffb\u8bd1\u540e\u4fee\u9970\uff0c\u5b58\u5728\u4e8e\u5927\u591a\u6570\u7ec6\u80de\u8868\u9762\u3002N-\u805a\u7cd6\u5728\u4f18\u5316\u6cbb\u7597\u80bd\u548c\u86cb\u767d\u8d28\u65b9\u9762\u53d1\u6325\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002\u7136\u800c\uff0c\u7531\u4e8e\u4f7f\u7528\u5f53\u524d\u7684\u57fa\u56e0\u8868\u8fbe\u7cfb\u7edf\u96be\u4ee5\u83b7\u5f97\u540c\u8d28\u7cd6\u86cb\u767d\uff0c\u7814\u7a76\u7cd6\u86cb\u767d\u7ed3\u6784\u4e0e\u529f\u80fd\u4e4b\u95f4\u7684\u5173\u7cfb\u4e00\u76f4\u5177\u6709\u6311\u6218\u6027\uff0c\u56e0\u4e3a\u901a\u8fc7\u975e\u6a21\u677f\u5316\u7ffb\u8bd1\u540e\u7cd6\u57fa\u5316\u751f\u7269\u5408\u6210\u7684\u7cd6\u86cb\u767d\u901a\u5e38\u4ee5\u96be\u4ee5\u5206\u79bb\u7684\u590d\u6742\u6df7\u5408\u7269\u5f62\u5f0f\u4ea7\u751f\u3002<\/p>\n<p>\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e2a\u95ee\u9898\uff0c\u4eba\u4eec\u5df2\u7ecf\u5f00\u53d1\u4e86\u591a\u79cd\u65b9\u6cd5\u6765\u5316\u5b66\u7ec4\u88c5 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\u7684\u80bd\u7684\u590d\u6742\u5149\u6c27\u5316\u8fd8\u539f\u65b9\u6cd5\uff0c\u7136\u800c\uff0c\u901a\u8fc7\u5149\u6c27\u5316\u8fd8\u539f\u50ac\u5316\u5408\u6210 N-\u8fde\u63a5\u7cd6\u80bd\u7684\u6f5c\u529b\uff08\u589e\u5f3a\u4e0d\u540c Dha \u529f\u80fd\u7684\u91cd\u8981\u7b56\u7565\uff09\u4ecd\u7136\u6ca1\u6709\u5f97\u5230\u5145\u5206\u7814\u7a76\u3002<\/p>\n<p>\u5728\u8fd9\u7bc7\u6587\u7ae0\u4e2d\uff0c\u4f5c\u8005\u9996\u6b21\u62a5\u9053\u4e86 N-\u7cd6\u57fa\u8349\u80fa\u9178\u4e0e\u542b\u6709 Dhas \u7684\u590d\u6742\u80bd\u7684\u53ef\u89c1\u5149\u4ecb\u5bfc\u7684\u5409\u65af\u53cd\u5e94\uff0c\u901a\u8fc7\u540e\u671f\u4fee\u9970\u65b9\u6cd5\u4ea7\u751f\u4e86 N-\u8fde\u63a5\u7684\u7cd6\u80bd\uff08\u65b9\u6848 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W\uff09\u4e0b\uff0c\u8fdb\u884c\u80bd\u00a0<strong>1<\/strong>\u00a0\u4e0e\u4f5c\u4e3a\u81ea\u7531\u57fa\u524d\u4f53\u7684 N-\u7cd6\u57fa\u8349\u80fa\u9178\u00a02\u00a0\u7684\u81ea\u7531\u57fa\u5076\u8054\u300212 \u5c0f\u65f6\u540e\uff0c\u7eaf\u5316\u5f97\u5230\u6240\u9700\u7684 N-\u8fde\u63a5\u7cd6\u80bd<strong>\u00a05-a\u00a0<\/strong>\u548c\u00a0<strong>5-b<\/strong>\uff0c\u4e3a\u4e24\u79cd\u975e\u5bf9\u6620\u4f53\u7684\u51e0\u4e4e\u76f8\u7b49\u7684\u6df7\u5408\u7269\uff0cLC-MS \u4ea7\u7387\u4e3a 71%\uff0c\u5177\u6709\u9ad8\u4f4d\u70b9\u9009\u62e9\u6027\uff08\u65b9\u6848 2D\uff0c\u6761\u76ee 1\uff09\u3002\u4e24\u79cd\u975e\u5bf9\u6620\u4f53\uff08<strong>5-a<\/strong>\u00a0\u548c\u00a0<strong>5-b<\/strong>\uff09\u7684\u7ed3\u6784\u901a\u8fc7\u5408\u6210\u6807\u51c6\u7cd6\u80bd\u5f97\u5230\u4e86\u786e\u8ba4\u3002\u800c\u5728\u6ca1\u6709\u7167\u5c04\u7684\u60c5\u51b5\u4e0b\uff0c\u672a\u68c0\u6d4b\u5230\u6240\u9700\u4ea7\u7269\u7684\u75d5\u8ff9\uff08\u65b9\u6848 2D\uff0c\u6761\u76ee 5\uff09\u3002\u5982\u65b9\u6848 2F \u6240\u793a\uff0c\u4f7f\u7528\u4f18\u5316\u7684\u5149\u6c27\u5316\u8fd8\u539f\u6761\u4ef6\uff0c\u80bd\u00a0<strong>1\u00a0<\/strong>\u4e0e\u542b\u6709\u4e0d\u540c\u4f4e\u805a\u7cd6\u57fa\u56e2\u7684\u5404\u79cd N-\u7cd6\u57fa\u8349\u80fa\u9178\u53cd\u5e94\u3002\u8fd9\u4e9b\u8bd5\u5242\u53ef\u4ee5\u5f88\u5bb9\u6613\u5730\u4ece\u7cd6\u80fa\u6216\u7cd6\u57fa\u53e0\u6c2e\u901a\u8fc7\u4e09\u6b65\u5236\u5907\uff0c\u4ea7\u7387\u5f88\u9ad8\u3002\u603b\u7684\u6765\u8bf4\uff0c\u53ef\u4ee5\u4f18\u5f02\u7684\u4ea7\u7387\u83b7\u5f97\u542b\u6709\u5355\u7cd6\u3001\u53cc\u7cd6\u548c\u4e09\u805a\u7cd6\u7684\u7cd6\u80bd\uff08<strong>6-14<\/strong>\uff09\uff0c\u800c\u5176\u4e2d\u542b\u6709\u4e09\u7cd6\u57fa\u5e8f\u7684\u4ea7\u7269\u00a0<strong>14<\/strong>\u00a0\u7684\u4ea7\u7387\u8d85\u8fc7 84%\u3002\u5e76\u4e14\u65b9\u6848 2G \u663e\u793a\uff0c\u6240\u9009\u53cd\u5e94\u6df7\u5408\u7269\u7684\u56fe\u8c31\u8868\u660e\u53cd\u5e94\u4ee5\u9ad8\u9009\u62e9\u6027\u8fdb\u884c\uff0c\u4ec5\u4ea7\u751f\u5fae\u91cf\u7684\u526f\u4ea7\u7269\u3002<\/p>\n<\/section>\n<section>\n<section><img decoding=\"async\" title=\"3\" src=\"https:\/\/17332.seohost.cn\/storage\/17332\/article\/20250318\/1742263998545688.png\" alt=\"3\" \/><\/section>\n<p>\u65b9\u6848 2 \u5149\u6c27\u5316\u8fd8\u539f\u50ac\u5316\u5236\u5907 N-\u8fde\u63a5\u7cd6\u80bd\u7684\u8fdb\u5c55\u3002<\/p>\n<\/section>\n<section>\u63a5\u7740\u4f5c\u8005\u4f7f\u7528\u6e90\u81ea\u4e0d\u540c\u957f\u5ea6\u548c\u7ec4\u6210\u7684\u5929\u7136\u86cb\u767d\u8d28\u7684\u80bd\u53d7\u4f53\u8fdb\u4e00\u6b65\u63a2\u7d22\u4e86\u8fd9\u79cd\u7cd6\u57fa\u5316\u65b9\u6cd5\u7684\u8303\u56f4\uff08\u65b9\u6848 3A\uff09\u3002\u4f5c\u8005\uff0c\u542b\u6709 11-18 \u4e2a\u6c28\u57fa\u9178\u7684\u00a0<span class=\"\">TIGIT<\/span>\uff08T30-S40\uff0c<strong>15<\/strong>\uff09\u3001SIGLEC-15\uff08A166-A180\uff0c<strong>16<\/strong>\uff09\u548c PD-1\uff08L65-F82\uff0c<strong>17<\/strong>\uff09\u4e0e N-\u7cd6\u57fa\u8349\u80fa\u9178\u00a0<strong>2<\/strong>\u00a0\u53cd\u5e94\u826f\u597d\uff0c\u5728\u84dd\u8272 LED \u7167\u5c04\u4e0b\u4ea7\u751f N-\u7cd6\u57fa\u5316\u80bd\uff08<strong>20-22<\/strong>\uff09\uff0c\u4ea7\u7387\u4e3a 62%-85%\u3002\u800c\u4e2d\u7b49\u5927\u5c0f\u7684\u80bd\uff0822-34\u4e2a\u6b8b\u57fa\uff09\u5728\u8fd9\u79cd\u8f6c\u5316\u4e2d\u4e5f\u8868\u73b0\u826f\u597d\u3002\u5f53\u7528 N-\u7cd6\u57fa\u8349\u80fa\u9178\u00a0<strong>2<\/strong>\u00a0\u8fdb\u884c\u7cd6\u57fa\u5316\u65f6\uff0cPD-L1\uff08F211-A232\uff0c<strong>18<\/strong>\uff09\u548c HSV-1 \u7684 gD\uff08R92-F125\uff0c<strong>19<\/strong>\uff09\u4ea7\u51fa\u4e86 N-\u7cd6\u80bd\uff08<strong>23\u00a0<\/strong>\u548c\u00a0<strong>24<\/strong>\uff09\uff0c\u4ea7\u7387\u4e3a 60%-68%\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5316\u5b66\u5408\u6210\u7684\u7cd6\u80bd\u9002\u5408\u4e8e\u9176\u4fc3\u7cd6\u57fa\u5316\u3002\u5982\u65b9\u6848 3B \u6240\u793a\uff0c\u4f7f\u7528\u7cd6\u57fa\u8f6c\u79fb\u9176 Endo-M N175Q \u4fee\u9970\u7cd6\u57fa\u5316\u80bd SIGLEC-15\uff08A166-A180\uff09\u7247\u6bb5<strong>\u00a021<\/strong>\u00a0\u548c PD-L1\uff08F211- A232\uff09\u7247\u6bb5\u00a0<strong>23<\/strong>\u00a0\u4ee5\u6784\u5efa\u590d\u5408 N-\u7cd6\u80bd\u3002\u8fd9\u4e9b\u7cd6\u80bd\u7684\u4e24\u79cd\u975e\u5bf9\u6620\u4f53\uff08<strong>21<\/strong>\u00a0\u548c\u00a0<strong>23<\/strong>\uff09\u4e0e\u553e\u6db2\u9178\u5316\u7684\u7cd6\u57fa\u6c27\u5511\u55ea\u53cd\u5e94\uff0c\u4ee5\u4f18\u5f02\u7684\u4ea7\u7387\u4ea7\u751f\u6240\u9700\u7684<span class=\"\">\u590d\u5408\u7cd6\u80bd<\/span>\uff08<strong>25\u00a0<\/strong>\u548c\u00a0<strong>26<\/strong>\uff09\u3002<\/p>\n<\/section>\n<section>\n<section><img decoding=\"async\" title=\"4\" src=\"https:\/\/17332.seohost.cn\/storage\/17332\/article\/20250318\/1742264009911123.png\" alt=\"4\" \/><\/section>\n<p>\u65b9\u6848 3 \u6e90\u81ea\u5929\u7136\u86cb\u767d\u8d28\u548c\u9176\u4fc3\u7cd6\u57fa\u5316\u7684\u80bd\u53d7\u4f53<\/p>\n<\/section>\n<section>\u7136\u540e\u4f5c\u8005\u53d1\u73b0\u8fd9\u79cd\u8f6c\u5316\u5bf9\u4e00\u7cfb\u5217\u751f\u7269\u6d3b\u6027\u80bd\u548c<span class=\"\">\u80bd\u836f\u7269<\/span>\u5747\u6709\u6548\uff0c\u4f8b\u5982\u7279\u5229\u52a0\u538b\u7d20\uff08\u7528\u4e8e\u6cbb\u7597\u809d\u80be\u7efc\u5408\u5f81\uff09\u3001Lynronne-1\uff08\u4e00\u79cd\u6297\u83cc\u80bd\uff09\u548c\u66ff\u52a0\u6ce2\u80bd\uff08\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u6fc0\u7d20\u96be\u6cbb\u6027\u524d\u5217\u817a\u764c\uff09\uff08\u65b9\u6848 4A\uff09\u3002\u6240\u6709\u8fd9\u4e9b\u751f\u7269\u6d3b\u6027\u80bd\u90fd\u7ecf\u8fc7\u4f4d\u70b9\u9009\u62e9\u6027\u5409\u65af\u53cd\u5e94\uff0c\u4ea7\u751f\u6240\u9700\u7684 N-\u7cd6\u80bd\uff08<strong>27-29<\/strong>\uff09\uff0cLC-MS \u4ea7\u7387\u8303\u56f4\u4e3a 64%-77%\u3002\u5e76\u4e14\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u7279\u5229\u52a0\u538b\u7d20\u662f\u4e00\u79cd\u5177\u6709\u4e00\u4e2a\u4e8c\u786b\u6865\u7684\u73af\u80bd\u3002\u8fd9\u4e9b\u4f8b\u5b50\u8868\u660e\uff0c\u8fd9\u79cd\u81ea\u7531\u57fa\u4ecb\u5bfc\u7684\u65b9\u6cd5\u4e0e\u6240\u76ee\u6807\u80bd\u4e2d\u7684\u6240\u6709\u86cb\u767d\u8d28\u539f\u6c28\u57fa\u9178\uff08\u9664\u81ea\u7531\u534a\u4e73\u7cd6\u5916\uff09\u76f8\u5bb9\u3002\u800c\u8be5\u53cd\u5e94\u7684\u5b9e\u7528\u6027\u5728\u6297\u751f\u7d20\u786b\u94fe\u83cc\u7d20\u7684\u540e\u671f\u529f\u80fd\u5316\u4e2d\u5f97\u5230\u4e86\u8fdb\u4e00\u6b65\u8bc1\u660e\u3002\u786b\u94fe\u83cc\u7d20\u662f\u4e00\u79cd\u7531 26 \u4e2a\u6c28\u57fa\u9178\u7ec4\u6210\u7684\u73af\u5f62\u590d\u6742\u80bd\uff0c\u5b83\u5408\u6210\u7684\u6311\u6218\u6027\u548c\u6eb6\u89e3\u6027\u5dee\u9650\u5236\u4e86\u5176\u5728\u4e34\u5e8a\u4e2d\u7684\u4f7f\u7528\u3002\u4f5c\u8005\u4f7f\u7528\u65b0\u7684\u5408\u6210\u65b9\u6cd5\u5bf9 Dha\u00a0<strong>16<\/strong>\u00a0\u8fdb\u884c\u4e86\u7cd6\u57fa\u5316\uff0c\u5408\u6210\u4e86<strong>\u00a030<\/strong>\uff0cLC-MS \u4ea7\u7387\u4e3a 47%\u3002\u901a\u8fc7\u6838\u78c1\u5171\u632f\u5149\u8c31\u6cd5\u8bc1\u5b9e\u4e86\u4fee\u9970\u80bd\uff08<strong>30<\/strong>\uff09\u7684\u7ed3\u6784\u3002<\/p>\n<p>\u4e4b\u540e\u4f5c\u8005\u8bc4\u4f30\u4e86\u4fee\u9970\u80bd\u7684\u751f\u7269\u6d3b\u6027\uff0c\u53d1\u73b0 Lynronne-1 \u5728\u4fee\u9970\u540e\u4fdd\u7559\u4e86\u663e\u8457\u7684\u6297\u83cc\u529f\u6548\uff0c<span class=\"\">\u6700\u4f4e\u6291\u5236\u6d53\u5ea6<\/span>\uff08MIC\uff09\u4e3a 8 \u03bcg\/mL\u3002\u5e76\u4e14\u6709\u8da3\u7684\u662f\uff0cLynronne-1\uff08<strong>28<\/strong>\uff0cL\/D\uff09\u7684\u7cd6\u57fa\u5316\u53d8\u4f53\u5728\u80ce\u725b\u8840\u6e05\u4e2d\u8868\u73b0\u51fa\u4e86\u7a33\u5b9a\u6027\u7684\u589e\u5f3a\uff0c\u8d85\u51fa\u4e86\u4f5c\u8005\u6700\u521d\u7684\u9884\u671f\u3002\u540c\u65f6\uff0c\u4f5c\u8005\u4f7f\u7528 MCF-7 \u4e73\u817a\u764c\u7ec6\u80de\u7cfb\u8bc4\u4f30\u4e86\u4fee\u9970\u540e\u7684\u66ff\u52a0\u6ce2\u80bd\u00a0<strong>29<\/strong>\u00a0\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002\u7ed3\u679c\u8868\u660e\uff0c\u4e0e\u672a\u4fee\u9970\u7684\u66ff\u52a0\u6ce2\u80bd\u76f8\u6bd4\uff0c\u7cd6\u57fa\u5316\u5f62\u5f0f\u7684\u66ff\u52a0\u6ce2\u80bd\u8868\u73b0\u51fa\u66f4\u597d\u7684\u6297\u80bf\u7624\u6027\u80fd\u3002<\/p>\n<\/section>\n<section>\n<section><img decoding=\"async\" title=\"5\" src=\"https:\/\/17332.seohost.cn\/storage\/17332\/article\/20250318\/1742264019752731.png\" alt=\"5\" \/><\/section>\n<p>\u65b9\u6848 4 \u751f\u7269\u6d3b\u6027\u80bd\u53ca\u751f\u7269\u6d3b\u6027\u5b9e\u9a8c<\/p>\n<\/section>\n<section>\u6700\u540e\u6839\u636e\u5b9e\u9a8c\u7ed3\u679c\u548c\u73b0\u6709\u6587\u732e\uff0c\u4f5c\u8005\u63d0\u51fa\u4e86\u8be5\u53cd\u5e94\u7684\u53ef\u80fd\u673a\u5236\uff08\u65b9\u6848 5\uff09\u3002\u5728\u84dd\u8272 LED \u7167\u5c04\u4e0b\uff0c[Ir<sup>\u2162<\/sup>]*\uff08E<sub>1\/2 red<\/sub>\u00a0[Ir<sup>\u2162*<\/sup>\/Ir<sup>\u2161<\/sup>] = +1.21 V vs SCE in CH<sub>3<\/sub>CN\uff09\u4ea7\u751f\u5149\u6fc0\u53d1\u3002\u5728\u94ef\u5b58\u5728\u4e0b\uff0c\u8349\u80fa\u9178\u00a0<strong>31\u00a0<\/strong>\u88ab\u8f6c\u5316\u4e3a\u8349\u9178\u76d0\u00a0<strong>32<\/strong>\u3002\u8349\u9178\u76d0<strong>\u00a032<\/strong>\u00a0\u7684\u6c27\u5316\u52bf\u4e3a +1.17V\uff0c\u5728\u9010\u6b65\u635f\u5931\u4e00\u5206\u5b50 CO<sub>2 \u00a0<\/sub>\u540e\uff0c\u5b83\u53ef\u4ee5\u88ab [Ir<sup>\u2162<\/sup>]* \u6c27\u5316\uff0c\u901a\u8fc7\u5355\u7535\u5b50\u8f6c\u79fb\uff08SET\uff09\u5f62\u6210\u6c28\u7532\u6c27\u81ea\u7531\u57fa\u00a0<strong>33<\/strong>\u3002\u968f\u540e\u00a0<strong>33<\/strong>\u00a0\u4e0e\u7f3a\u7535\u5b50 Dha \u6b8b\u57fa\u00a0<strong>34<\/strong>\u00a0\u4e4b\u95f4\u53d1\u751f\u5409\u65af\u53cd\u5e94\u4ea7\u751f\u81ea\u7531\u57fa\u4e2d\u95f4\u4f53\u00a0<strong>35<\/strong>\uff0c\u7136\u540e\u901a\u8fc7 [Ir<sup>\u2161<\/sup>] \u8fdb\u884c\u5355\u7535\u5b50\u8fd8\u539f\u5f62\u6210\u8d1f\u78b3\u79bb\u5b50\u00a0<strong>36<\/strong>\u3002\u968f\u540e\u8fdb\u884c\u4e2d\u95f4\u4f53\u00a0<strong>36<\/strong>\u00a0\u7684\u8d28\u5b50\u5316\uff0c\u5f97\u5230\u6240\u9700\u7684 N-\u8fde\u63a5\u7cd6\u80bd\u00a0<strong>37<\/strong>\u3002<\/p>\n<\/section>\n<section>\n<section><img decoding=\"async\" title=\"6\" src=\"https:\/\/17332.seohost.cn\/storage\/17332\/article\/20250318\/1742264032477004.png\" alt=\"6\" \/>\u200b<\/section>\n<p>\u65b9\u6848 5 \u63d0\u51fa\u7684\u5149\u50ac\u5316\u5076\u8054\u52a0\u6210\u53cd\u5e94\u673a\u5236<\/p>\n<\/section>\n<section>\u603b\u800c\u8a00\u4e4b\uff0c\u4f5c\u8005\u5f00\u53d1\u4e86\u4e00\u79cd\u4f7f\u7528\u5149\u6c27\u5316\u8fd8\u539f\u50ac\u5316\u5409\u65af\u52a0\u6210\u5408\u6210 N-\u8fde\u63a5\u7cd6\u80bd\u7684\u901a\u7528\u7b56\u7565\u3002\u4e0e\u5f53\u524d\u4f9d\u8d56\u4e8e\u5f62\u6210\u80fa\u952e\u7684\u65b9\u6cd5\u4e0d\u540c\uff0c\u8be5\u7b56\u7565\u901a\u8fc7 N-\u7cd6\u57fa\u8349\u80fa\u9178\u4e0e\u542b\u6709 Dha \u7684\u80bd\u7684\u5076\u8054\u6765\u6784\u5efa N-\u8fde\u63a5\u7684\u7cd6\u80bd\u3002\u8fd9\u79cd\u65b9\u6cd5\u6761\u4ef6\u6e29\u548c\uff0c\u53ef\u4ee5\u5728\u5e7f\u6cdb\u7684\u80bd\u4e2d\u8fdb\u884c\u4f4d\u70b9\u9009\u62e9\u6027 N-\u7cd6\u57fa\u5316\u3002\u8fd9\u6709\u52a9\u4e8e\u5408\u6210\u542b\u6709 Dha \u7684\u5176\u4ed6\u751f\u7269\u6d3b\u6027\u80bd\u7684 N-\u7cd6\u57fa\u5316\u80bd\u7c7b\u4f3c\u7269\u3002\u7cd6\u57fa\u5316\u540e\u89c2\u5bdf\u5230\u7684\u7a33\u5b9a\u6027\u548c\u6d3b\u6027\u7684\u6539\u5584\u8fdb\u4e00\u6b65\u8bc1\u660e\u4e86\u8be5\u7b56\u7565\u7684\u5b9e\u7528\u6027\u3002\u8fd9\u79cd\u65b9\u6cd5\u5c06\u4e3a\u751f\u7269\u5b66\u548c\u6cbb\u7597\u7814\u7a76\u63d0\u4f9b\u4e00\u79cd\u6709\u4ef7\u503c\u7684\u5de5\u5177\u3002<\/p>\n<\/section>\n<section>\u672c\u6587\u4f5c\u8005\uff1aJX<\/p>\n<p>\u539f\u6587\u94fe\u63a5\uff1a<\/p>\n<p>https:\/\/doi.org\/10.1002\/anie.202415565<\/p>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>\u5206\u4eab\u7684\u662f\u4e00\u7bc7\u53d1\u8868\u5728 Angewandte Chemie International Edition \u4e0a\u7684\u6587\u7ae0\uff0c [&hellip;]<\/p>\n","protected":false},"author":326,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[],"class_list":["post-53591","post","type-post","status-publish","format-standard","hentry","category-tuijianyuedu"],"_links":{"self":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/53591","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/users\/326"}],"replies":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/comments?post=53591"}],"version-history":[{"count":1,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/53591\/revisions"}],"predecessor-version":[{"id":53592,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/53591\/revisions\/53592"}],"wp:attachment":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/media?parent=53591"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/categories?post=53591"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/tags?post=53591"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}