{"id":53566,"date":"2025-03-22T08:30:16","date_gmt":"2025-03-22T00:30:16","guid":{"rendered":"https:\/\/www.chemhui.com\/?p=53566"},"modified":"2025-03-13T10:33:03","modified_gmt":"2025-03-13T02:33:03","slug":"nat-commun-%e4%b8%b4%e8%bf%91%e8%9b%8b%e7%99%bd%e8%b4%a8%e7%bb%84%e5%ad%a6%e6%8f%ad%e7%a4%ba%e4%ba%86%e8%84%82%e8%82%aa%e9%85%b8%e5%9c%a8%e8%84%82%e6%bb%b4-%e7%ba%bf%e7%b2%92%e4%bd%93-%e5%86%85","status":"publish","type":"post","link":"http:\/\/www.chemhui.com\/nat-commun-%e4%b8%b4%e8%bf%91%e8%9b%8b%e7%99%bd%e8%b4%a8%e7%bb%84%e5%ad%a6%e6%8f%ad%e7%a4%ba%e4%ba%86%e8%84%82%e8%82%aa%e9%85%b8%e5%9c%a8%e8%84%82%e6%bb%b4-%e7%ba%bf%e7%b2%92%e4%bd%93-%e5%86%85\/","title":{"rendered":"Nat. Commun. | \u4e34\u8fd1\u86cb\u767d\u8d28\u7ec4\u5b66\u63ed\u793a\u4e86\u8102\u80aa\u9178\u5728\u8102\u6ef4-\u7ebf\u7c92\u4f53-\u5185\u8d28\u7f51\u63a5\u89e6\u4f4d\u70b9\u8f6c\u79fb\u673a\u5236"},"content":{"rendered":"<p>\u5206\u4eab\u4e00\u7bc7\u53d1\u8868\u5728Nature Communications\u4e0a\u7684\u6587\u7ae0\uff0c\u9898\u76ee\u4e3a \u201cProximity proteomics reveals a mechanism of fatty acid transfer at lipid dropletmitochondria- endoplasmic reticulum contact sites\u201d\uff0c\u901a\u8baf\u4f5c\u8005\u662f\u6765\u81ea\u6fb3\u5927\u5229\u4e9a\u58a8\u5c14\u672c\u5927\u5b66\u89e3\u5256\u751f\u7406\u5b66\u7cfb\u7684 Matthew J. Watt \u6559\u6388\u3002<\/p>\n<section><img decoding=\"async\" title=\"1\" src=\"https:\/\/10110.seohost.cn\/storage\/10110\/article\/20250313\/1741833098671370.jpg\" alt=\"1\" \/><\/section>\n<p>\u7ec6\u80de\u5668\u4e4b\u95f4\u7684\u819c\u63a5\u89e6\u4f4d\u70b9\u5bf9\u4e8e\u751f\u7269\u5206\u5b50\u7684\u8f6c\u79fb\u81f3\u5173\u91cd\u8981\uff0c\u8102\u6ef4\u50a8\u5b58\u8102\u80aa\u9178\u5e76\u4e0e\u7ebf\u7c92\u4f53\u63a5\u89e6\uff0c\u7ebf\u7c92\u4f53\u53ef\u4ee5\u8c03\u8282<span class=\"\">\u8102\u80aa\u9178\u6c27\u5316<\/span>\u548cATP\u7684\u751f\u6210\u3002\u4f46\u662f\u76ee\u524d\u7f3a\u4e4f\u5bf9\u4e8e\u8102\u6ef4-\u7ebf\u7c92\u4f53\u63a5\u89e6\u4f4d\u70b9\u7684\u86cb\u767d\u8d28\u5206\u5e03\u4ee5\u53ca\u5b83\u4eec\u7684\u5177\u4f53\u751f\u7269\u5b66\u529f\u80fd\u7684\u89e3\u6790\uff0c\u672c\u6587\u5e0c\u671b\u7ed3\u5408\u4e34\u8fd1\u6807\u8bb0\u548c<span class=\"\">\u86cb\u767d\u8d28\u7ec4\u5b66\u6280\u672f<\/span>\u5bf9\u8102\u6ef4-\u7ebf\u7c92\u4f53\u63a5\u89e6\u4f4d\u70b9\u7684\u86cb\u767d\u8d28\u7ec4\u8fdb\u884c\u65e0\u504f\u5730\u5206\u6790\uff0c\u63ed\u5f00\u8102\u80aa\u9178\u4ece\u50a8\u5b58\u90e8\u4f4d\u8f6c\u79fb\u5230\u6c27\u5316\u90e8\u4f4d\u7684\u673a\u5236\u3002<\/p>\n<p>\u4f5c\u8005\u91c7\u7528\u00a0<span class=\"\">BioID<\/span>\u00a0\u4e34\u8fd1\u6807\u8bb0\u7b56\u7565\u6765\u89e3\u6790\u8102\u6ef4-\u7ebf\u7c92\u4f53\u63a5\u89e6\u4f4d\u70b9\u95f410\uff5e30 nm\u7684\u86cb\u767d\u8d28\u5206\u5e03\u3002\u8fd9\u4e2a\u7b56\u7565\u5c06\u5927\u80a0\u6746\u83cc<span class=\"\">\u751f\u7269\u7d20<\/span>\u8fde\u63a5\u9176BirA\u7a81\u53d8\u4f53BirA*\uff08\u53ef\u4ee5\u5c06\u751f\u7269\u7d20\u6807\u8bb0\u5230\u4e34\u8fd1\u86cb\u767d\uff09,\u5355\u4f53\u8367\u5149\u86cb\u767d\u548c\u9776\u5411\u4fe1\u53f7\u80bd\uff0810\uff5e30\u4e2a\u6c28\u57fa\u9178\uff0c\u5c06BirA*\u5b9a\u4f4d\u5230\u8102\u6ef4\u6216\u7ebf\u7c92\u4f53\uff09\u6574\u5408\u5230\u4e00\u8d77\uff0c\u53ef\u4ee5\u5c06\u8102\u6ef4\u6216\u7ebf\u7c92\u4f53\u5916\u819c\u7684\u4e34\u8fd1\u86cb\u767d\u8d34\u4e0a\u751f\u7269\u7d20\u6807\u7b7e\uff0c\u901a\u8fc7\u94fe\u9709\u4eb2\u6838\u7d20\u73e0\u5bcc\u96c6\u518d\u8fdb\u884c\u8d28\u8c31\u9274\u5b9a\u3002\u4f7f\u7528\u9488\u5bf9\u8102\u6ef4\u7684\u5168\u957fBirA*\uff0c\u4f5c\u8005\u786e\u5b9a\u4e86974\u79cd\u86cb\u767d\u8d28\u4f4d\u4e8e\u8102\u6ef4\u9644\u8fd1\u7684\u86cb\u767d\u8d28\uff0c\u4f7f\u7528\u9488\u5bf9\u7ebf\u7c92\u4f53\u7684\u5168\u957fBirA*\u8bf1\u9975\uff0c\u4f5c\u8005\u786e\u5b9a\u4e86625\u79cd\u4f4d\u4e8e\u7ebf\u7c92\u4f53\u5916\u819c\u9644\u8fd1\u7684\u86cb\u767d\u8d28\u3002\u540c\u65f6\u4f5c\u8005\u8fd8\u8fd0\u7528 Split-BiolD \u7b56\u7565\uff0c\u5c06BirA*\u5206\u6210\u4e24\u4e2a\u975e\u529f\u80fd\u7247\u6bb5\u5206\u522b\u9776\u5411\u8102\u6ef4\u548c\u7ebf\u7c92\u4f53\u5916\u819c\uff0c\u5f53\u4e24\u4e2a\u7247\u6bb5\u878d\u5408\u65f6BirA*\u91cd\u65b0\u7ec4\u88c5\u4ee5\u6062\u590d\u6d3b\u6027\uff0c\u5c06\u751f\u7269\u7d20\u6807\u8bb0\u5230\u8102\u6ef4\u548c\u7ebf\u7c92\u4f53\u76f8\u4e92\u4f5c\u7528\u754c\u9762\u7684\u86cb\u767d\u8d28\u4e0a\uff0c\u7531\u6b64\u4f5c\u8005\u786e\u5b9a\u4e86\u6d3b\u7ec6\u80de\u4e2d\u8102\u6ef4-\u7ebf\u7c92\u4f53\u754c\u9762\u768481\u79cd\u86cb\u767d\u8d28\u3002\u4ee5\u4e0a\u4e09\u4e2a\u4e34\u8fd1\u6807\u8bb0\u5b9e\u9a8c\u540c\u65f6\u9274\u5b9a\u523071\u4e2a\u86cb\u767d\u8d28\uff0c\u4f5c\u8005\u5c06\u8fd9\u4e9b\u86cb\u767d\u8d28\u5b9a\u4e49\u4e3a\u8102\u6ef4-\u7ebf\u7c92\u4f53\u754c\u9762\u86cb\u767d\u3002<\/p>\n<section><img decoding=\"async\" title=\"2\" src=\"https:\/\/10110.seohost.cn\/storage\/10110\/article\/20250313\/1741833107833264.jpg\" alt=\"2\" \/><\/section>\n<p>\u901a\u8fc7\u5bf9\u8fd971\u4e2a\u8102\u6ef4-\u7ebf\u7c92\u4f53\u754c\u9762\u86cb\u767d\u8fdb\u884c\u751f\u7269\u4fe1\u606f\u5b66\u5206\u6790\uff0c\u4f5c\u8005\u5173\u6ce8\u5230\u5b9a\u4f4d\u5728\u5185\u8d28\u7f51\u548c\u7ebf\u7c92\u4f53\u63a5\u89e6\u4f4d\u70b9\u3001\u53c2\u4e0e\u8102\u8d28\u8fd0\u8f93ESYT1\u86cb\u767d\u3002\u4f5c\u8005\u8fdb\u884c\u4e86\u514d\u75ab\u5171\u6c89\u6dc0\u5b9e\u9a8c\u6765\u5bfb\u627eESYT1\u662f\u5426\u5728\u8102\u6ef4-\u7ebf\u7c92\u4f53\u7684\u63a5\u89e6\u4f4d\u70b9\u4e0e\u5176\u4ed6\u86cb\u767d\u8d28\u5f62\u6210\u590d\u5408\u7269\uff0c\u7ed3\u679c\u4e2dVAPB\u548cESYT2\u86cb\u767d\u662f\u8102\u6ef4-\u7ebf\u7c92\u4f53\u754c\u9762\u86cb\u767d\u3002\u4f5c\u8005\u901a\u8fc7\u514d\u75ab\u5370\u8ff9\u548c\u514d\u75ab\u6c89\u6dc0\u8bc1\u5b9e\u4e86ESYT1\uff0cESYT2\u548cVAPB\u4e09\u4e2a\u86cb\u767d\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u9ad8\u5206\u8fa8\u7387\u6210\u50cf\u8bc1\u5b9e\u4e86\u8fd9\u4e09\u79cd\u86cb\u767d\u4f1a\u5f62\u6210\u590d\u5408\u7269\u5b9a\u4f4d\u5728\u8102\u6db2\u6ef4-\u7ebf\u7c92\u4f53-\u5185\u8d28\u7f51\u754c\u9762\u3002<\/p>\n<section><img decoding=\"async\" title=\"6\" src=\"https:\/\/10110.seohost.cn\/storage\/10110\/article\/20250313\/1741833115920375.jpg\" alt=\"6\" \/><\/section>\n<p>\u6700\u540e\u4f5c\u8005\u5bf9\u8102\u6ef4-\u7ebf\u7c92\u4f53\u754c\u9762\u4e2dESYT1-ESYT2-VAPB\u590d\u5408\u7269\u7684\u529f\u80fd\u8fdb\u884c\u7814\u7a76\u53d1\u73b0\u8be5\u590d\u5408\u7269\u53ef\u4ee5\u4fdd\u62a4\u7ec6\u80de\u514d\u53d7\u8102\u80aa\u6bd2\u6027\u7684\u5f71\u54cd\u3002\u4ed6\u4eec\u6572\u9664\u4e86HeLa\u7ec6\u80de\u4e2d\u7684ESYT1-ESYT2-VAPB\u590d\u5408\u7269\u5e76\u7528<span class=\"\">\u68d5\u6988\u9178\u76d0<\/span>\u8bf1\u5bfc\u7ec6\u80de\u5e94\u6fc0\u548c\u6b7b\u4ea1\uff0c\u53d1\u73b0\u5176\u4e0e\u91ce\u751f\u578b\u76f8\u6bd4\uff0cKO\u7ec6\u80de\u7cfb\u7684\u5185\u8d28\u7f51\u5e94\u6fc0\u3001\u708e\u75c7\u53cd\u5e94\u7b49\u663e\u8457\u4e0a\u8c03\u3002<\/p>\n<section><img decoding=\"async\" title=\"7\" src=\"https:\/\/10110.seohost.cn\/storage\/10110\/article\/20250313\/1741833127107724.jpg\" alt=\"7\" \/>\u200b<\/section>\n<p>\u603b\u800c\u8a00\u4e4b\u4f5c\u8005\u7ed3\u5408\u4e34\u8fd1\u6807\u8bb0\u548c\u86cb\u767d\u8d28\u7ec4\u5b66\u6280\u672f\u89e3\u6790\u4f4d\u4e8e\u8102\u6ef4-\u7ebf\u7c92\u4f53\u754c\u9762\u86cb\u767d\u5e76\u53d1\u73b0\u4e86\u4e00\u79cd\u7531ESYT1\uff0cESYT2\u548cVAPB\u7ec4\u6210\u7684\u591a\u805a\u4f53\u86cb\u767d\u590d\u5408\u7269\uff0c\u5b83\u5bf9\u4e8e\u4fdd\u62a4\u7ec6\u80de\u514d\u53d7\u8102\u80aa\u6bd2\u6027\u7684\u5f71\u54cd\u81f3\u5173\u91cd\u8981\u3002<\/p>\n<p>\u672c\u6587\u4f5c\u8005\uff1aTZM<\/p>\n<p>\u8d23\u4efb\u7f16\u8f91\uff1aLYC<\/p>\n<p>DOI\uff1a10.1038\/s41467-025-57405-5<\/p>\n<p>\u539f\u6587\u94fe\u63a5\uff1ahttps:\/\/doi.org\/10.1038\/s41467-025-57405-5<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5206\u4eab\u4e00\u7bc7\u53d1\u8868\u5728Nature Communications\u4e0a\u7684\u6587\u7ae0\uff0c\u9898\u76ee\u4e3a \u201cProximity proteom [&hellip;]<\/p>\n","protected":false},"author":326,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[],"class_list":["post-53566","post","type-post","status-publish","format-standard","hentry","category-tuijianyuedu"],"_links":{"self":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/53566","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/users\/326"}],"replies":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/comments?post=53566"}],"version-history":[{"count":1,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/53566\/revisions"}],"predecessor-version":[{"id":53567,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/53566\/revisions\/53567"}],"wp:attachment":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/media?parent=53566"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/categories?post=53566"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/tags?post=53566"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}