{"id":53485,"date":"2025-03-06T08:20:39","date_gmt":"2025-03-06T00:20:39","guid":{"rendered":"https:\/\/www.chemhui.com\/?p=53485"},"modified":"2025-02-25T10:27:50","modified_gmt":"2025-02-25T02:27:50","slug":"nat-chem-biol-%e6%bf%80%e9%85%b6%e8%b0%83%e6%8e%a7%e7%9a%84%e7%94%9f%e7%89%a9%e8%8d%a7%e5%85%89%e7%8e%b0%e8%b1%a1%e6%8f%ad%e7%a4%baakt%e8%8d%af%e7%89%a9%e7%9a%84%e8%8d%af%e6%95%88%e5%8a%a8","status":"publish","type":"post","link":"http:\/\/www.chemhui.com\/nat-chem-biol-%e6%bf%80%e9%85%b6%e8%b0%83%e6%8e%a7%e7%9a%84%e7%94%9f%e7%89%a9%e8%8d%a7%e5%85%89%e7%8e%b0%e8%b1%a1%e6%8f%ad%e7%a4%baakt%e8%8d%af%e7%89%a9%e7%9a%84%e8%8d%af%e6%95%88%e5%8a%a8\/","title":{"rendered":"Nat. Chem. Biol. | \u6fc0\u9176\u8c03\u63a7\u7684\u751f\u7269\u8367\u5149\u73b0\u8c61\u63ed\u793aAkt\u836f\u7269\u7684\u836f\u6548\u52a8\u529b\u5b66\u7279\u6027"},"content":{"rendered":"
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\u6700\u540e\uff0c\u4f5c\u8005\u5229\u7528KiMBI\u65b9\u6cd5\u6d4b\u5b9a\u4e86\u4e00\u79cdAkt PROTAC\uff0c\u5e76\u53d1\u73b0\u5176\u6709\u8f83\u957f\u7684\u836f\u6548\u52a8\u529b\u5b66\u534a\u8870\u671f\u3002\u56e2\u961f\u8ba4\u4e3a\u8fd9\u8bf4\u660e\u8fd9\u6b3ePROTAC\u7c7b\u836f\u7269\u4e5f\u8bb8\u53ef\u4ee5\u51cf\u5c11\u7ed9\u836f\u6b21\u6570\uff0c\u63d0\u9ad8\u6cbb\u7597\u6548\u7387\u3002<\/p>\n \u603b\u800c\u8a00\u4e4b\uff0c\u56e2\u961f\u901a\u8fc7\u5f00\u53d1\u4e86\u4e00\u79cd\u4f9d\u8d56\u751f\u7269\u8367\u5149\u4fe1\u53f7\u7684Akt\u6291\u5236\u5242\u836f\u6548\u52a8\u529b\u5b66\u7279\u6027\u6307\u793a\u4f53\u7cfb\uff0c\u4e3a\u8bc4\u4ef7\u548c\u63a2\u7d22\u65b0\u7684Akt\u6291\u5236\u5242\u63d0\u4f9b\u4e86\u624b\u6bb5\uff0c\u4e5f\u4e3a\u5f00\u53d1\u5176\u4ed6\u7c7b\u4f3c\u4f53\u7cfb\u505a\u51fa\u4e86\u8d21\u732e\u3002<\/p>\n \u672c\u6587\u4f5c\u8005\uff1aZYH<\/p>\n \u8d23\u4efb\u7f16\u8f91\uff1aWYQ<\/p>\n DOI\uff1a10.1038\/s41589-025-01846-y<\/p>\n \u539f\u6587\u94fe\u63a5\uff1ahttps:\/\/doi.org\/10.1038\/s41589-025-01846-y<\/p>\n","protected":false},"excerpt":{"rendered":" \u63a8\u8350\u4e00\u7bc7\u53d1\u8868\u5728Nat. 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Biol.\u4e0a\u7684\u6587\u7ae0\uff0c\u9898\u76ee\u4e3a\u201cPharmacodynamics of Akt […]<\/p>\n","protected":false},"author":326,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-53485","post","type-post","status-publish","format-standard","hentry","category-dingzhiganhuo"],"_links":{"self":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/53485","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/users\/326"}],"replies":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/comments?post=53485"}],"version-history":[{"count":1,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/53485\/revisions"}],"predecessor-version":[{"id":53486,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/53485\/revisions\/53486"}],"wp:attachment":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/media?parent=53485"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/categories?post=53485"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/tags?post=53485"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}<\/p>\n
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