{"id":52781,"date":"2024-11-16T08:33:35","date_gmt":"2024-11-16T00:33:35","guid":{"rendered":"https:\/\/www.chemhui.com\/?p=52781"},"modified":"2024-11-07T10:33:59","modified_gmt":"2024-11-07T02:33:59","slug":"jacs-%e4%b8%80%e7%a7%8d%e6%98%93%e4%ba%8e%e8%8e%b7%e5%8f%963faxneu5ac%e5%92%8c%e5%85%89%e4%ba%a4%e8%81%94%e5%94%be%e6%b6%b2%e9%85%b8%e8%bd%ac%e7%a7%bb%e9%85%b6%e6%8e%a2%e9%92%88%e7%9a%84%e5%8a%a8","status":"publish","type":"post","link":"http:\/\/www.chemhui.com\/jacs-%e4%b8%80%e7%a7%8d%e6%98%93%e4%ba%8e%e8%8e%b7%e5%8f%963faxneu5ac%e5%92%8c%e5%85%89%e4%ba%a4%e8%81%94%e5%94%be%e6%b6%b2%e9%85%b8%e8%bd%ac%e7%a7%bb%e9%85%b6%e6%8e%a2%e9%92%88%e7%9a%84%e5%8a%a8\/","title":{"rendered":"JACS | \u4e00\u79cd\u6613\u4e8e\u83b7\u53d63FaxNeu5Ac\u548c\u5149\u4ea4\u8054\u553e\u6db2\u9178\u8f6c\u79fb\u9176\u63a2\u9488\u7684\u52a8\u529b\u5b66\u65b9\u6cd5"},"content":{"rendered":"
\u5206\u4eab\u4e00\u7bc7\u53d1\u8868\u5728JACS\u4e0a\u7684\u6587\u7ae0\uff1a\u201cA Kinetic Trapping Approach for Facile Access to 3Fax<\/sub>Neu5Ac and a Photo-Cross-Linkable Sialyl transferase Probe\u201d\uff0c\u5176\u901a\u8baf\u4f5c\u8005\u662f\u963f\u5c14\u4f2f\u5854\u5927\u5b66\u7684Matthew S. Macauley\u535a\u58eb\uff0c\u4ed6\u5bf9\u7cd6\u7c7b\u7269\u8d28\u7684\u7814\u7a76\u5145\u6ee1\u70ed\u60c5\uff0c\u8fd9\u4e0d\u4ec5\u4f53\u73b0\u5728\u4ed6\u7684\u7814\u7a76\u5de5\u4f5c\u4e2d\uff0c\u4e5f\u5ef6\u4f38\u5230\u4e86\u6559\u5b66\u548c\u6307\u5bfc\u5b66\u751f\u7b49\u591a\u4e2a\u65b9\u9762\u3002<\/section>\n

 <\/p>\n

\"1\"<\/section>\n
\u553e\u6db2\u9178<\/span>\u00a0(Neu5Ac) \u662f\u4e00\u79cd\u4e5d\u78b3\u03b1-\u916e\u9178\u5355\u7cd6\u3002\u553e\u6db2\u9178\u8f6c\u79fb\u9176 (ST) \u5c06\u80de\u82f7\u5355\u78f7\u9178-Neu5Ac (CMP-\u03b2-D-Neu5Ac) \u7684Neu5Ac\u5b89\u88c5\u5230\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u7684\u7cd6\u7f00\u5408\u7269\u4e0a\u3002\u63a2\u6d4b\u5355\u4e2aST\u5bb6\u65cf\u6210\u5458\u7684\u5316\u5b66\u5de5\u5177\u53d7\u5230\u79d1\u5b66\u5bb6\u4eec\u7684\u5173\u6ce8\uff0c\u800c\u5177\u6709\u7ec6\u80de\u6d3b\u6027<\/span>\u7684ST\u6291\u5236\u5242\u662f\u57fa\u4e8e3Fax<\/sub>Neu5Ac (3<\/strong>) \u652f\u67b6\u7684\u5206\u5b50\uff0c\u5b83\u5728\u7ec6\u80de\u5185\u4ee3\u8c22\u8f6c\u5316\u4e3aCMP-3Fax<\/sub>Neu5Ac (5<\/strong>)\u3002\u6c1f\u7684\u8f74\u5411\u6027\u5f88\u5173\u952e\uff0c\u4f46\u5728\u8fd9\u7279\u5b9a\u65b9\u5411\u5b89\u88c5\u6c1f\u662f\u6709\u6311\u6218\u7684\u3002<\/p>\n

\u5316\u5b66\u5408\u6210\u6cd5\u5b58\u5728\u6b65\u9aa4\u591a\u3001\u6536\u7387\u4f4e\uff0c\u9700\u901a\u8fc7\u8272\u8c31\u7eaf\u5316\u6765\u5206\u79bb3Fax<\/sub>\u548c3Feq<\/sub>\u5f02\u6784\u4f53\u7b49\u7f3a\u9677\u3002\u7531\u919b\u7f29\u9176\u4ecb\u5bfc\u7684\u5316\u5b66\u9176\u6cd5\u4e5f\u5b58\u5728\u53cd\u5e94\u53ef\u9006\u3001\u53d7\u70ed\u529b\u63a7\u5236\u3001\u9700\u8272\u8c31\u7eaf\u5316\u5f02\u6784\u4f53\u7b49\u4e0d\u8db3\u3002\u4e8e\u662f\uff0c\u4f5c\u8005\u63d0\u51fa\u901a\u8fc7\u8054\u7528\u553e\u6db2\u9178\u919b\u7f29\u9176\u4e0eCMP-\u553e\u6db2\u9178\u5408\u6210\u9176\u6765\u6355\u83b73Fax<\/sub>\u7684\u52a8\u529b\u5b66\u4ea7\u7269\uff0c\u5e76\u4ee560%\u7684\u6536\u7387\u83b7\u5f97\u4e86CMP-3Fax<\/sub>Neu5Ac(Scheme 1)\u3002<\/p>\n<\/section>\n

\"2\"<\/section>\n
Scheme 1. \u52a8\u529b\u5b66\u6355\u83b7CMP-3Fax<\/sub>Neu5Ac<\/p>\n

 <\/p>\n

\u5316\u5408\u72695<\/strong>\u5728\u9178\u6027\u6761\u4ef6\u4e0b\u4e0d\u80fd\u76f4\u63a5\u8f6c\u5316\u62103<\/strong>\uff0c\u800c\u662f\u5148\u751f\u62107<\/strong>\u00a0(3Fax<\/sub>-Neu5Ac-2P)\uff0c\u7136\u540e\u7ecf\u78b1\u6027\u78f7\u9178\u9176<\/span>\u00a0(ALP)\u50ac\u5316\u83b7\u5f97\u76ee\u6807\u4ea7\u7269\u3002\u4e3a\u4e86\u91cf\u5316F\u7f13\u89e35<\/strong>\u6c34\u89e3\u7684\u7a0b\u5ea6\uff0c\u4f5c\u8005\u8fdb\u884c\u4e86\u57fa\u4e8eMS \u7684\u52a8\u529b\u5b66\u5206\u6790\uff0c\u5206\u522b\u5c062<\/strong>\u548c5<\/strong>\u6c34\u89e3\u62101<\/strong>\u548c7<\/strong>\uff0c\u7ed3\u679c\u53d1\u73b0C3\u4f4d\u7f6e\u7684F\u53d6\u4ee3\u4f7f\u6c34\u89e3\u901f\u7387\u964d\u4f4e\u4e86\u7ea6100\u500d\uff08\u56fe1\uff09\u3002<\/p>\n<\/section>\n

\"3\"<\/section>\n
\u56fe1. \u901a\u8fc7\u4e2d\u95f4\u4f537<\/strong>\u5c06 CMP-3Fax<\/sub>Neu5Ac (5<\/strong>)\u8f6c\u6362\u4e3a3Fax<\/sub>Neu5Ac (3<\/strong>)<\/p>\n

 <\/p>\n

\u968f\u540e\uff0c\u4f5c\u8005\u5728U937\u7ec6\u80de\u6d4b\u8bd53a<\/strong>\uff0c\u53d1\u73b0\u5b83\u80fd\u6709\u6548\u964d\u4f4eSiglec-1, -2, -3, -5, -7, -8\u548c-15\u7684\u553e\u6db2\u9178\u805a\u7cd6\u914d\u4f53\u6c34\u5e73\uff08\u56fe2\uff09\u3002<\/p>\n<\/section>\n

\"4\"<\/section>\n
\u56fe2. 3Fax<\/sub>Neu5Ac\u964d\u4f4e\u7ec6\u80de\u5185Siglec\u914d\u4f53\u6c34\u5e73<\/p>\n

 <\/p>\n

\u63a5\u4e0b\u6765\uff0c\u4f5c\u8005\u68c0\u9a8c\u52a8\u529b\u5b66\u6355\u83b7\u65b9\u6cd5\u80fd\u5426\u6709\u6548\u83b7\u5f975<\/strong>\u7684\u884d\u751f\u7269\u3002\u5982Scheme 2\u6240\u793a\uff0c\u4f5c\u8005\u901a\u8fc7\u7ea7\u8054\u9176\u6cd5\u987a\u5229\u83b7\u5f97\u517c\u5177\u5149\u4ea4\u8054<\/span>\u57fa\u56e2\u548c\u70b9\u51fb\u624b\u67c4\u7684\u53cc\u5b98\u80fd\u884d\u751f\u7269\u3002\u76f8\u6bd4\u4e4b\u524d\u7684\u5408\u6210\u65b9\u6cd5\uff0c\u8be5\u65b0\u578b\u5316\u5b66\u9176\u6cd5\uff0c\u6b65\u9aa4\u5c11\u3001\u4ea7\u7387\u9ad8\u3002<\/p>\n<\/section>\n

\"5\"<\/section>\n
Scheme 2. CMP-9-N-DAz-3Fax<\/sub>Neu5Al (11<\/strong>) \u7684\u5408\u6210<\/p>\n

 <\/p>\n

\u63a5\u4e0b\u6765\uff0c\u4f5c\u8005\u5c06\u5149\u4ea4\u8054\u63a2\u948811<\/strong>\u4e0e\u4e09\u79cd\u4eba\u6e90\u91cd\u7ec4\u7684ST\uff1aST6GAL1, ST3GAL1\u548cST3GAL4\u8fdb\u884cUV\u4ea4\u8054\u6d4b\u8bd5\u3002\u9996\u5148\uff0c\u4f5c\u8005\u4f7f\u752811<\/strong>\u4e0e\u4e09\u79cd\u9ad8\u6d53\u5ea6 (500 \u03bcM) \u7684ST\u8fdb\u884c\u6d4b\u8bd5\uff0c\u89c2\u5bdf\u523011<\/strong>\u5bf9ST6GAL1\u4ea7\u751f\u5f3a\u7684UV\u4f9d\u8d56\u6027\u5149\u4ea4\u8054\uff0c\u5bf9ST3GAL4\u6709\u6700\u5f31\u7684UV\u4f9d\u8d56\u6027\u5149\u4ea4\u8054\uff0c\u4e14\u4e0eST3GAL1\u65e0\u5149\u4ea4\u8054\u3002\u968f\u540e\uff0c\u964d\u4f4e11<\/strong>\u7684\u6d53\u5ea6\uff0c\u53d1\u73b011<\/strong>\u5bf9ST3GAL1\u6709\u660e\u663e\u7684\u9009\u62e9\u6027\uff0c\u751a\u81f3\u53ea\u970010 \u03bcM\u00a011<\/strong>\u53ef\u5b9e\u73b0\u4e0e\u4e24\u8005\u7684\u5149\u4ea4\u8054\u3002\u5f53\u589e\u52a0CMP-Neu5Ac (2<\/strong>) \u7684\u6d53\u5ea6\u65f6\uff0c11<\/strong>\u5bf9ST6GAL1\u6d3b\u6027\u4f4d\u70b9\u7684\u7279\u5f02\u6027\u4f1a\u88ab\u7ade\u4e89\u6027\u6291\u5236\uff08\u56fe3\uff09\u3002<\/p>\n<\/section>\n

\"6\"<\/section>\n
\u56fe3. ST6GAL1\u4e0e11<\/strong>\u7684\u9009\u62e9\u6027\u5149\u4ea4\u8054<\/p>\n

 <\/p>\n

\u6700\u540e\uff0c\u4f5c\u8005\u8bc4\u4f30\u4e86\u5316\u5408\u726911<\/strong>\u548c5<\/strong>\u5bf9ST6GAL1, ST3GAL1\u548cST3GAL4\u7684\u6291\u5236\u5f3a\u5ea6\u548c\u4eb2\u548c\u529b\u3002\u7ed3\u679c\u8868\u660e\uff0c\u4e0e5<\/strong>\u76f8\u6bd4\uff0c11<\/strong>\u5bf9ST6GAL1\u7684\u6291\u5236\u529b\u7a0d\u6709\u589e\u52a0\uff1b\u5bf9ST3GAL4\u6709\u76f8\u4f3c\u7684\u6291\u5236\u5f3a\u5ea6\uff1b\u5bf9ST3GAL1\u7f3a\u4e4f\u6291\u5236\u6548\u529b\u3002\u53e6\u4e00\u9762\uff0c11<\/strong>\u4e0eST3GAL1\u7684\u7ed3\u5408\u8f83\u5dee\uff0c\u4e0eST6GAL1, ST3GAL4\u6709\u76f8\u4f3c\u7684\u7ed3\u5408\u5f3a\u5ea6\uff08\u56fe4\uff09\u3002<\/p>\n<\/section>\n

\"7\"<\/section>\n
\u56fe4.\u00a05<\/strong>\u548c11<\/strong>\u5bf9\u4e09\u4e2aST\u7684\u4eb2\u548c\u529b\u548c\u6291\u5236\u529b\u6d4b\u91cf<\/p>\n

 <\/p>\n

\u603b\u4e4b\uff0c\u4f5c\u8005\u62a5\u544a\u4e86\u4e00\u79cd\u5feb\u901f\u3001\u7cbe\u51c6\u5408\u6210ST\u63a2\u9488 (CMP-3Fax<\/sub>Neu5Ac) \u7684\u52a8\u529b\u5b66\u65b9\u6cd5\uff0c\u5e76\u4e14\u9a8c\u8bc1\u4e86\u8be5\u65b9\u6cd5\u53ef\u7528\u4e8e\u83b7\u5f97C5, C9\u4f4d\u7f6e\u6539\u9020\u7684\u63a2\u9488\uff0c\u53ca\u5176\u80fd\u5b9e\u73b0\u4e0d\u540cST\u95f4\u7684\u9009\u62e9\u6027\u4ea4\u8054\u3002<\/p>\n<\/section>\n

 <\/p>\n

 <\/p>\n

\u6587\u7ae0\u4f5c\u8005\uff1aYX<\/p>\n

\u539f\u6587\u94fe\u63a5\uff1ahttps:\/\/pubs.acs.org\/doi\/10.1021\/jacs.4c10835<\/p>\n

\u8d23\u4efb\u7f16\u8f91\uff1aWXL<\/p>\n<\/section>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u5206\u4eab\u4e00\u7bc7\u53d1\u8868\u5728JACS\u4e0a\u7684\u6587\u7ae0\uff1a\u201cA Kinetic Trapping Approach for Facile […]<\/p>\n","protected":false},"author":326,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[],"class_list":["post-52781","post","type-post","status-publish","format-standard","hentry","category-tuijianyuedu"],"_links":{"self":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/52781","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/users\/326"}],"replies":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/comments?post=52781"}],"version-history":[{"count":1,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/52781\/revisions"}],"predecessor-version":[{"id":52782,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/52781\/revisions\/52782"}],"wp:attachment":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/media?parent=52781"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/categories?post=52781"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/tags?post=52781"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}