{"id":52399,"date":"2024-09-29T08:06:06","date_gmt":"2024-09-29T00:06:06","guid":{"rendered":"https:\/\/www.chemhui.com\/?p=52399"},"modified":"2024-09-20T10:11:14","modified_gmt":"2024-09-20T02:11:14","slug":"%e8%a5%bf%e6%b9%96%e5%a4%a7%e5%ad%a6%e9%82%93%e5%8a%9b%e6%95%99%e6%8e%88%e5%9b%a2%e9%98%9fjacs%ef%bc%9a%e6%b0%a8%e5%9f%ba%e8%85%88%e7%9a%84%e7%bb%bf%e8%89%b2%e5%90%88%e6%88%90","status":"publish","type":"post","link":"http:\/\/www.chemhui.com\/%e8%a5%bf%e6%b9%96%e5%a4%a7%e5%ad%a6%e9%82%93%e5%8a%9b%e6%95%99%e6%8e%88%e5%9b%a2%e9%98%9fjacs%ef%bc%9a%e6%b0%a8%e5%9f%ba%e8%85%88%e7%9a%84%e7%bb%bf%e8%89%b2%e5%90%88%e6%88%90\/","title":{"rendered":"\u897f\u6e56\u5927\u5b66\u9093\u529b\u6559\u6388\u56e2\u961fJACS\uff1a\u6c28\u57fa\u8148\u7684\u7eff\u8272\u5408\u6210"},"content":{"rendered":"<p>\u8fd1\u65e5\uff0c\u897f\u6e56\u5927\u5b66\u7406\u5b66\u9662\u9093\u529b\u56e2\u961f\u5728\u8457\u540d\u5316\u5b66\u6742\u5fd7\u300a\u7f8e\u56fd\u5316\u5b66\u4f1a\u5fd7\u300b\u4e0a\u53d1\u8868\u4e86\u9898\u4e3a\u201cSynthesis of a-Aminonitriles via Ammonium-catalyzed Reactions of Aminoacetonitrile\u201d\u7684\u7814\u7a76\u8bba\u6587\u3002<\/p>\n<p>\u0251-\u6c28\u57fa\u8148\u4e0d\u4ec5\u662f\u7528\u9014\u6781\u5176\u5e7f\u6cdb\u7684\u5408\u6210\u780c\u5757\uff0c\u4e5f\u662f\u5177\u6709\u751f\u7269\u6d3b\u6027\u5929\u7136\u4ea7\u7269\u4ee5\u53ca\u836f\u7269\u5206\u5b50\u5982\u65b0\u51a0\u836f\u7269<span class=\"\">Paxlovid<\/span>\u7684\u7ed3\u6784\u5355\u5143\u3002\u65e9\u57281850\u5e74\uff0cStrecker\u5c31\u62a5\u9053\u4e86\u901a\u8fc7\u919b\u3001\u4f2f\u80fa\u548c\u6c30\u5316\u7269\u5236\u5907a-\u6c28\u8148\u7684\u5408\u6210\u65b9\u6cd5\u3002\u7531\u4e8e\u0251-\u6c28\u57fa\u8148\u7684\u91cd\u8981\u6027\uff0c 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class=\"\">\u4e09\u7532\u57fa\u6c30\u7845\u70f7<\/span>\uff08TMSCN\uff09\u7b49\uff0c\u4f7f\u5f97Strecker\u53cd\u5e94\u4e0d\u4ec5\u5371\u5bb3\u73af\u5883\uff0c\u751a\u81f3\u64cd\u4f5c\u5371\u9669\u3002\u56e0\u800c\uff0c\u5f00\u53d1\u53cd\u5e94\u64cd\u4f5c\u7b80\u5355\u3001\u53ef\u517c\u5bb9\u6c34\u6c27\u800c\u5e7f\u6cdb\u9002\u7528\u4e14\u7eff\u8272\u73af\u4fdd\u7684\u0251-\u6c28\u8148\u5408\u6210\u65b9\u6cd5\u5177\u6709\u91cd\u8981\u610f\u4e49\u548c\u5e7f\u9614\u7684\u5e94\u7528\u524d\u666f\u3002<\/p>\n<p>\u9093\u529b\u6559\u6388\u56e2\u961f\u5f00\u53d1\u4e86\u4e00\u79cd<em>a<\/em>-\u6c28\u8148\u7684\u7eff\u8272\u5408\u6210\u7b56\u7565\u3002\u8be5\u7b56\u7565\u9009\u7528\u5ec9\u4ef7\u6613\u5f97\u4e14\u65e0\u6bd2\u7684\u6c28\u57fa\u4e59\u8148\u76d0\u9178\u76d0\uff0812 $\/kg\uff09\u4e3a\u8d77\u59cb\u539f\u6599\u3002\u76f8\u6bd4\u4e8e\u76ee\u524d\u5e38\u7528\u7684Strecker\u53cd\u5e94\uff0c\u8be5\u65b9\u6cd5\u907f\u514d\u4e86\u5267\u6bd2\u6027\u6c30\u5316\u8bd5\u5242\u5982<span class=\"\">\u6c22\u6c30\u9178<\/span>\u3001\u6c30\u5316\u94a0\uff08\u94be\uff09\u548c\u4e09\u7532\u57fa\u6c30\u7845\u70f7\u7b49\u3002\u5728\u5b63\u94f5\u76d0\u50ac\u5316\u4e0b\uff0c\u6c28\u57fa\u4e59\u8148\u884d\u751f\u7269\u4e0e\u7ed3\u6784\u79cd\u7c7b\u591a\u6837\u7684\u4eb2\u7535\u8bd5\u5242\u53d1\u751f\u4eb2\u7535\u4eb2\u6838\u53cd\u5e94\uff0c\u5b9e\u73b0\u7ed3\u6784\u591a\u6837\u7684<em>a<\/em>-\u6c28\u8148\u7684\u7eff\u8272\u5408\u6210\uff08\u56fe1D\uff09\u30021987\u5e74\uff0cTsuge\u548c\u540c\u4e8b\u62a5\u9053\u4e86N-(1-\u6c30\u57fa\u70f7\u57fa\u4e9a\u80fa)\u7684\u70f7\u57fa\u5316\u53cd\u5e94\u3002\u7136\u800c\uff0c\u53cd\u5e94\u9700\u8981\u6d88\u8017\u5316\u5b66\u8ba1\u91cf\u7684<span class=\"\">\u4e8c\u5f02\u4e19\u57fa\u80fa\u57fa\u9502<\/span>\uff08LDA\uff09\uff0c\u7531\u4e8eLDA\u5bf9\u6c34\u6c27\u90fd\u6781\u5176\u654f\u611f\uff0c\u53cd\u5e94\u5fc5\u987b\u5728\u65e0\u6c34\u65e0\u6c27\u7684\u82db\u523b\u6761\u4ef6\u4e0b\u65b9\u53ef\u8fdb\u884c\u3002Tsuge\u4e5f\u62a5\u9053\u4e86\u57280.1-1.1\u500d\u5f53\u91cf\u76841,8-\u4e8c\u6c2e\u6742\u53cc\u73af\uff085.4.0\uff09\u5341\u4e00-7-\u70ef\uff08DBU\uff09\u4ecb\u5bfc\u4e0b\u7684 1,4-\u52a0\u6210\u53cd\u5e94\uff08\u56fe1C\uff09\u3002\u9093\u529b\u56e2\u961f\u53d1\u73b0\u57280.1\u5f53\u91cf\u5ec9\u4ef7\u5e76\u4e14\u4e0e\u6c34\u6c27\u517c\u5bb9\u7684\u5b63\u94f5\u76d0\u5546\u54c1\u8bd5\u5242\uff08\u5982\u56db\u4e01\u57fa\u6eb4\u5316\u94f5[TBAB]\u7b49\uff09\u4f5c\u7528\u4e0b\uff0c<em>N<\/em>-\u82b3\u4e9a\u80fa\u6c28\u57fa\u4e59\u8148\u53ef\u4e0e\u70f7\u57fa\u6eb4\u548c\u5171\u8f6d\u52a0\u6210\u53d7\u4f53\u53d1\u751f\u53cd\u5e94\u751f\u6210\u6d88\u65cb\u4f53<em>\u0251<\/em>-\u6c28\u8148\u3002\u4f5c\u8005\u8fdb\u4e00\u6b65\u5c55\u793a\u4e86\uff0c\u5728\u624b\u6027\u5b63\u94f5\u76d0\u50ac\u5316\u4e0b\uff0c<em>N<\/em>-\u82b3\u4e9a\u80fa\u6c28\u57fa\u4e59\u8148\u53ef\u53d1\u751f\u4e0d\u5bf9\u79f01,4-\u52a0\u6210\u53cd\u5e94\u751f\u6210\u9ad8\u5149\u5b66\u6d3b\u6027\u7684\u624b\u6027<em>\u0251<\/em>-\u6c28\u8148\u3002\u8fd9\u4e00\u7b56\u7565\u4e0d\u4ec5\u540c\u65f6\u9002\u7528\u4e8e\u5408\u6210\u5177\u6709<em>\u0251<\/em>-\u53d4\u78b3\u4e2d\u5fc3\u548c<em>\u0251<\/em>-\u5b63\u78b3\u4e2d\u5fc3\u7684<em>\u0251<\/em>-\u6c28\u8148\uff0c\u800c\u4e14\u8fd8\u80fd\u5408\u6210\u5177\u6709\u76f8\u90bb\u624b\u6027\u4e2d\u5fc3\u7684<em>\u0251<\/em>-\u6c28\u8148\u3002\u503c\u5f97\u5173\u6ce8\u7684\u662f\uff0c\u4f5c\u8005\u8fd8\u5c55\u793a\u4e86\u8fd9\u4e9b\u53cd\u5e94\u53ef\u653e\u5927\u514b\u7ea7\u751a\u81f3\u5341\u514b\u7ea7\u89c4\u6a21\uff0c\u53c8\u5c55\u793a\u4e86<em>\u00a0\u0251<\/em>-\u6c28\u8148\u4ea7\u7269\u7684<em>N<\/em>-\u82b3\u4e9a\u80fa\u57fa\u56e2\u53ef\u8f7b\u6613\u6c34\u89e3\u53bb\u9664\u3002\u4e0a\u8ff0\u7b56\u7565\u9009\u7528\u65e0\u6bd2\u539f\u6599\u548c\u8bd5\u5242\uff0c\u64cd\u4f5c\u7b80\u5355\uff0c\u5e7f\u6cdb\u9002\u7528\u4e8e\u7ed3\u6784\u591a\u6837\u7684<em>\u0251<\/em>-\u6c28\u8148\u5408\u6210\uff0c\u53ef\u653e\u5927\u751f\u4ea7\uff0c\u53ef\u884d\u751f\u5408\u6210\uff0c\u56e0\u6b64\u5177\u6709\u53d1\u5c55\u6210\u4e3a\u901a\u7528\u6027<em>a<\/em>-\u6c28\u8148\u7eff\u8272\u5408\u6210\u7684\u524d\u666f\u3002\u897f\u6e56\u5927\u5b66\u67f3\u7965\u5706\u535a\u58eb\u3001\u9093\u79b9\u535a\u58eb\uff0c\u9093\u606c\u7136\u535a\u58eb\u4e3a\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\uff0c\u901a\u8baf\u4f5c\u8005\u662f\u897f\u6e56\u5927\u5b66\u9093\u529b\u6559\u6388\u548c\u7f57\u6d4e\u751f\u526f\u7814\u7a76\u5458\u3002<\/p>\n<p><img decoding=\"async\" title=\"1\" src=\"https:\/\/10110.seohost.cn\/storage\/10110\/article\/20240920\/1726798180259484.png\" alt=\"1\" \/>\u56fe1.<em>\u0251<\/em>-\u6c28\u8148\u7684\u5408\u6210\u65b9\u6cd5<\/p>\n<p>&nbsp;<\/p>\n<p>\u5728\u6587\u7ae0\u4e2d\uff0c\u4f5c\u8005\u9009\u7528\u5546\u4e1a\u53ef\u5f97\u4e14\u5ec9\u4ef7\u65e0\u6bd2\u7684\u6c28\u57fa\u4e59\u8148\u76d0\u9178\u76d0\u4e3a\u8148\u6e90\u548c\u8d77\u59cb\u539f\u6599\u5408\u6210<em>a<\/em>-\u6c28\u8148\uff08\u6c28\u57fa\u4e59\u8148\u76d0\u9178\u76d0\u96f6\u552e\u4ef7\uff1a19 \u7f8e\u5143\/\u516c\u65a4\uff0c Adamas\uff1b\u5927\u5b97\u4ef7\u683c\uff1a12 \u7f8e\u5143\/\u516c\u65a4\uff0c\u5357\u4eac\u4e5d\u5c71\u5316\u5de5\uff09\uff0c\u4ece\u800c\u907f\u514d\u4e86\u4f7f\u7528\u6bd2\u6027\u6c30\u57fa\u5316\u8bd5\u5242\u3002<strong>\u4ee5\u5ec9\u4ef7\u6613\u5f97\u7684\u5b63\u94f5\u76d0\u4e3a\u50ac\u5316\u5242<\/strong>\uff08\u82c4\u57fa\u4e09\u4e59\u57fa\u6eb4\u5316\u94f5[benzyltriethylammonium bromide, Et<sub>3<\/sub>NBnBr, BTEAB]: \u96f6\u552e\u4ef7\uff1a47 \u7f8e\u5143\/\u516c\u65a4\uff0c\u6c5f\u82cf\u827e\u5eb7\uff1b\u56db\u4e01\u57fa\u6eb4\u5316\u94f5[tetrabutylammonium bromide, TBAI]: \u96f6\u552e\u4ef7\uff1a73 \u7f8e\u5143\/\u516c\u65a4\uff0c\u6c5f\u82cf\u827e\u5eb7\uff09\uff0c<strong><em>N<\/em>-\u82ef\u4e59\u4e9a\u80fa\u6c28\u57fa\u4e59\u8148(17a)\u4e0e\u591a\u79cd\u4eb2\u7535\u8bd5\u5242\u7684\u53cd\u5e94\u53ef\u5408\u6210\u6d88\u65cb\u4f53<em>a-<\/em>\u53d4\u78b3\u6c28\u8148\uff0820,\u00a0<\/strong><strong>\u56fe<\/strong><strong>2A\uff09<\/strong>\u3002\u6b64\u5916\uff0c<strong><em>N<\/em>-\u82ef\u7532\u4e9a\u80fa\u6c28\u57fa\u4e59\u8148\uff0812\uff09\u4e0e\u4eb2\u7535\u8bd5\u5242\u76f8\u7ee7\u53d1\u751f\u4e24\u6b21\u53cd\u5e94\u8fd8\u53ef\u751f\u6210<em>a-<\/em>\u5b63\u78b3\u6c28\u8148\uff0822\uff0c 23\uff09\u3002\u4f5c\u8005\u8fdb\u4e00\u6b65\u5c55\u793a\u4e86\u6b64\u7c7b\u53cd\u5e94\u53ef\u653e\u5927\u81f3\u5341\u514b\u7ea7\u89c4\u6a21\uff0823H-J,\u00a0<\/strong><strong>\u56fe<\/strong><strong>2B\uff09\u3002<\/strong><\/p>\n<p><img decoding=\"async\" title=\"2\" src=\"https:\/\/10110.seohost.cn\/storage\/10110\/article\/20240920\/1726798193191578.png\" alt=\"2\" 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