{"id":52322,"date":"2024-09-18T08:36:14","date_gmt":"2024-09-18T00:36:14","guid":{"rendered":"https:\/\/www.chemhui.com\/?p=52322"},"modified":"2024-09-09T10:36:42","modified_gmt":"2024-09-09T02:36:42","slug":"sci-adv-%e4%b8%80%e7%9f%b3%e4%ba%8c%e9%b8%9f%e7%9a%84%e5%8f%a3%e6%9c%8d%e7%ba%b3%e7%b1%b3%e7%96%97%e6%b3%95%e9%9d%b6%e5%90%91%e5%b0%8f%e8%82%a0%e6%95%b4%e5%90%88%e7%b4%a0","status":"publish","type":"post","link":"http:\/\/www.chemhui.com\/sci-adv-%e4%b8%80%e7%9f%b3%e4%ba%8c%e9%b8%9f%e7%9a%84%e5%8f%a3%e6%9c%8d%e7%ba%b3%e7%b1%b3%e7%96%97%e6%b3%95%e9%9d%b6%e5%90%91%e5%b0%8f%e8%82%a0%e6%95%b4%e5%90%88%e7%b4%a0\/","title":{"rendered":"Sci. Adv. | \u201c\u4e00\u77f3\u4e8c\u9e1f\u201d\u7684\u53e3\u670d\u7eb3\u7c73\u7597\u6cd5\u9776\u5411\u5c0f\u80a0\u6574\u5408\u7d20\u5e76\u8c03\u8282\u6c27\u5316\u8fd8\u539f\u7a33\u6001\u7528\u4e8e\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u6cbb\u7597"},"content":{"rendered":"<p>\u5206\u4eab\u4e00\u7bc7\u8fd1\u671f\u53d1\u8868<em>Science Advances<\/em>\u4e0a\u7684\u6587\u7ae0\uff0c\u9898\u76ee\u4e3a<em>\u201cTwo-birds-one-stone\u201d\u00a0oral nanotherapeutic\u00a0<\/em><em>designed<\/em><em>\u00a0to target intestinal integrins and regulate redox homeostasis for UC treatment<\/em>\u3002\u6587\u7ae0\u7684\u901a\u8baf\u4f5c\u8005\u662f\u6e05\u534e\u5927\u5b66\u7684\u90a2\u65b0\u4f1a\u6559\u6388\u3001\u738b\u6021\u52a9\u7406\u7814\u7a76\u5458\u548c\u5f20\u707f\u9633\u526f\u6559\u6388\u3002<\/p>\n<p>\u957f\u671f\u4f7f\u7528\u4f20\u7edf\u5c0f\u5206\u5b50\u836f\u7269\u548c\u514d\u75ab\u6291\u5236\u836f\u7269\u6cbb\u7597\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u53ef\u80fd\u5bfc\u81f4\u673a\u4f1a\u6027\u611f\u67d3\u3001\u6076\u6027\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u548c\u809d\u6bd2\u6027\u7b49\u526f\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u4e86\u89e3\u708e\u75c7\u4fe1\u53f7\u4f20\u5bfc\u5e76\u636e\u6b64\u5f00\u53d1\u7cbe\u51c6\u9012\u9001\u7b56\u7565\u5c24\u4e3a\u91cd\u8981\u3002\u73b0\u6709\u7684\u7cbe\u51c6\u9012\u9001\u7b56\u7565\u901a\u5e38\u5229\u7528\u708e\u75c7\u90e8\u4f4d\u7684\u5fae\u751f\u7269\u9176\u964d\u89e3\u3001pH\u6539\u53d8\u548c\u9ecf\u819c\u7535\u8377\u7ffb\u8f6c\u6765\u8fdb\u884c\u9776\u5411\uff0c\u4f46\u6d88\u5316\u9053\u75be\u75c5\u4e2d\u590d\u6742\u548c\u591a\u53d8\u7684\u73af\u5883\u4f1a\u5f71\u54cd\u8fd9\u79cd\u9776\u5411\u7684\u7cbe\u786e\u6027\u3002\u8003\u8651\u5230\u514d\u75ab\u7ec6\u80de\u5728\u75be\u75c5\u90e8\u4f4d\u7684\u79ef\u7d2f\uff0c\u4f7f\u7528\u9776\u5411\u514d\u75ab\u7ec6\u80de\u7684\u914d\u4f53\u5206\u5b50\u66f4\u5177\u6709\u524d\u666f\u3002<\/p>\n<p>&nbsp;<\/p>\n<section><img decoding=\"async\" title=\"1\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20240815\/1723687379103659.png\" alt=\"1\" 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decoding=\"async\" title=\"2\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20240815\/1723687393387407.webp\" alt=\"2\" \/><\/section>\n<section><strong>\u56fe<\/strong><strong>2.\u00a0<\/strong>OPNs@LMWH\u88abM1\u5de8\u566c\u7ec6\u80de\u5185\u5316\u5e76\u5728\u708e\u75c7\u7ed3\u80a0\u7ec4\u7ec7\u79ef\u7d2f<\/section>\n<section><\/section>\n<section>\u00a0\u00a0\u00a0\u00a0\u5982\u56fe2\u6240\u793a\uff0c\u672c\u6587\u4f5c\u8005\u6bd4\u8f83\u4e86OPNs\u548cOPNs@LMWH\u88ab\u4fc3\u708e\u514d\u75ab\u7ec6\u80de\u6444\u53d6\u7684\u80fd\u529b\u3002\u5c06\u4e24\u8005\u8fdb\u884c\u8367\u5149\u6807\u8bb0\u5e76\u7528CLSM\u6210\u50cf\uff0cOPNs@LMWH\u5177\u6709\u66f4\u5f3a\u7684\u8367\u5149\u4fe1\u53f7\uff0c\u4e14\u5f53\u7ec6\u80de\u8868\u9762\u7684\u53d7\u4f53\u6574\u5408\u7d20\u03b1M\u88ab\u5176\u4ed6\u6297\u4f53\u7ed3\u5408\u540e\uff0c\u8367\u5149\u660e\u663e\u51cf\u5f31\u3002\u4f5c\u8005\u901a\u8fc7\u53e3\u670d\u65bd\u7528\u786b\u9178\u94a0\u53f3\u65cb\u7cd6\uff08DSS\uff09\u5f97\u5230\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u9f20\u6a21\u578b\uff0c\u5e76\u53e3\u670d\u65bd\u7528OPNs@LMWH\u4ee5\u68c0\u6d4b\u5176\u751f\u7269\u5206\u5e03\u3002\u4f5c\u8005\u6210\u529f\u89c2\u5bdf\u5230\u5176\u5728\u635f\u4f24\u90e8\u4f4d\u7684\u79ef\u7d2f\uff0c\u4e14\u6bd4\u8d77OPNs\u5177\u6709\u66f4\u957f\u7684\u6ede\u7559\u65f6\u95f4\u3002<\/section>\n<section><img decoding=\"async\" title=\"3\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20240815\/1723687405292428.webp\" alt=\"3\" \/><\/section>\n<section><strong>\u56fe3<\/strong><strong>.<\/strong><strong>\u00a0<\/strong>OPNs\u6e05\u9664ROS\u548c\u4fc3\u708e\u6027\u7ec6\u80de\u56e0\u5b50<\/section>\n<section><\/section>\n<section>\u00a0\u00a0\u00a0\u00a0\u5982\u56fe3\u6240\u793a\uff0c\u4f5c\u8005\u8bc4\u4f30\u4e86OPNs@LMWH\u6e05\u9664ROS\u548c\u6297\u708e\u7684\u6548\u679c\u3002\u5728\u8bf1\u5bfc\u7ec6\u80de\u4ea7\u751fROS\u540e\uff0c\u4f5c\u8005\u5c06\u7ec6\u80de\u4e0e\u7eb3\u7c73\u7c92\u5b50\u5171\u5b75\u80b2\uff0c\u5e76\u901a\u8fc7\u8367\u5149\u6210\u50cf\u5bf9ROS\u8fdb\u884c\u5b9a\u91cf\u3002OPNs@LMWH\u663e\u793a\u51fa\u5f88\u597d\u7684\u6d53\u5ea6\u4f9d\u8d56\u7684ROS\u6e05\u9664\u80fd\u529b\uff0c\u4e14\u6bd4OPNs\u66f4\u52a0\u6709\u6548\uff0c\u8fd9\u53ef\u80fd\u662f\u7531\u4e8e\u5176\u66f4\u591a\u7684\u7ec6\u80de\u6444\u53d6\u3002\u6b64\u5916\uff0cOPNs@LMWH\u8fd8\u80fd\u6709\u6548\u51cf\u5c11ROS\u8bf1\u5bfc\u7684\u7ec6\u80de\u51cb\u4ea1\uff0c\u5e76\u51cf\u5c11IL-6\u548cTNF-\u03b1\u00a0\u7b49\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\u7684\u4ea7\u751f\u3002<\/section>\n<section><img decoding=\"async\" title=\"4\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20240815\/1723687413481003.webp\" alt=\"4\" \/><\/section>\n<section><strong>\u56fe4<\/strong><strong>.<\/strong><strong>\u00a0<\/strong>OPNs@LMWH\u7684\u6cbb\u7597\u6548\u679c<\/section>\n<section><\/section>\n<section>\u00a0\u00a0\u00a0\u00a0\u5982\u56fe4\u6240\u793a\uff0c\u4f5c\u8005\u8bc4\u4f30\u4e86OPNs@LMWH\u5bf9\u7ed3\u80a0\u708e\u5c0f\u9f20\u7684\u6cbb\u7597\u6548\u679c\u3002\u5bf9\u7ed3\u80a0\u708e\u5c0f\u9f20\u53e3\u670d\u65bd\u7528OPNs@LMWH\uff0c\u80fd\u591f\u6709\u6548\u6291\u5236\u5c0f\u9f20\u4f53\u91cd\u7684\u51cf\u8f7b\u548c\u7ed3\u80a0\u7684\u7f29\u77ed\u4ee5\u53ca\u813e\u810f\u7684\u6269\u5927\uff0c\u8bc1\u5b9e\u4e86\u5176\u5bf9\u7ed3\u80a0\u7684\u4fdd\u62a4\u6548\u679c\u3002\u7ec4\u7ec7\u5f62\u6001\u5b66\u4e0a\u7684\u6210\u50cf\u4e5f\u80fd\u8bc1\u5b9e\u8fd9\u4e00\u70b9\u3002\u00a0<\/section>\n<section><img decoding=\"async\" title=\"6\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20240815\/1723687424742331.webp\" alt=\"6\" \/><\/section>\n<section><strong>\u56fe5<\/strong><strong>.\u00a0<\/strong>OPNs@LMWH\u6062\u590d\u80a0\u9053\u5185\u7a33\u6001\u5e76\u4fdd\u62a4\u7ed3\u80a0\u4e0a\u76ae\u7ec6\u80de<\/section>\n<section><\/section>\n<section>\u00a0\u00a0\u00a0\u00a0\u5982\u56fe5\u6240\u793a\uff0c\u4f5c\u8005\u68c0\u6d4b\u4e86OPNs@LMWH\u6cbb\u7597\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u7684\u673a\u5236\u3002\u4f5c\u8005\u901a\u8fc7ELISA\u6d4b\u5f97OPNs@LMWH\u65bd\u7528\u540e\u8840\u6e05\u4e2d\u7684IL-6\u4ee5\u53ca\u7ed3\u80a0\u7ec4\u7ec7\u4e2d\u7684IL-6\u3001TNF-\u03b1\u3001IL-1\u03b2\u7684\u6d53\u5ea6\u90fd\u6709\u6240\u4e0b\u964d\uff0c\u63ed\u793a\u4e86OPNs@LMWH\u7684\u514d\u75ab\u8c03\u8282\u80fd\u529b\u3002\u514d\u75ab\u7ec4\u5316\u7ed3\u679c\u663e\u793aOPNs@LMWH\u65bd\u7528\u540e\u7eff\u8fc7\u6c27\u5316\u9176\uff08MPO\uff09\u9633\u6027\u7684\u7ec6\u80de\u51cf\u5c11\uff0c\u8bc1\u5b9e\u4e86\u5176\u80fd\u591f\u6291\u5236\u514d\u75ab\u7ec6\u80de\u4ea7\u751f\u8fc7\u91cf\u7684\u7ec6\u80de\u56e0\u5b50\uff0c\u4e14\u4f5c\u8005\u8fd8\u68c0\u6d4b\u5230\u88ab\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\u6fc0\u6d3b\u7684\u4fe1\u53f7\u8f6c\u5bfc\u901a\u8defJAK-STAT\u7684\u6fc0\u6d3b\u51cf\u5c11\u3002\u6b64\u5916\uff0c\u514d\u75ab\u8367\u5149\u67d3\u8272\u4e5f\u663e\u793a\u4e86\u80a0\u9053\u81ea\u7a33\u6001\u7684\u6062\u590d\u3002<\/section>\n<section>\u00a0\u00a0\u00a0\u00a0\u7efc\u4e0a\u6240\u8ff0\uff0c\u672c\u6587\u8bbe\u8ba1\u5236\u5907\u4e86\u4e00\u79cd\u9010\u5c42\u7eb3\u7c73\u7c92\u5b50\uff0c\u5185\u5c42\u4e3a\u4fee\u9970\u4e86\u6c27\u5316\u8fd8\u539f\u654f\u611f\u57fa\u56e2\u7684\u805a\u8d56\u6c28\u9178\uff0c\u5e76\u901a\u8fc7\u5e26\u6b63\u7535\u8377\u7684\u58f3\u805a\u7cd6\u4f5c\u4e3a\u4e2d\u95f4\u5c42\uff0c\u5728\u5916\u5c42\u5305\u88f9\u4e86\u5177\u6709\u708e\u75c7\u9776\u5411\u4f5c\u7528\u7684\u4f4e\u5206\u5b50\u91cf\u809d\u7d20\uff0c\u8be5\u7eb3\u7c73\u7c92\u5b50\u80fd\u591f\u540c\u65f6\u8d77\u5230\u9776\u5411\u708e\u75c7\u90e8\u4f4d\u9ad8\u8868\u8fbe\u7684\u6574\u5408\u7d20\u03b1M\u4ece\u800c\u5728\u7ed3\u80a0\u708e\u533a\u57df\u5bcc\u96c6\u4ee5\u53ca\u6e05\u9664ROS\u5e76\u51cf\u5c11\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\u7684\u4f5c\u7528\uff0c\u4ece\u800c\u5bf9\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u5b9e\u73b0\u6709\u6548\u6cbb\u7597\u3002<\/section>\n<section><strong>\u00a0<\/strong><\/section>\n<section><strong>\u4f5c\u8005<\/strong><strong>\uff1a<\/strong>ZHR\u00a0\u00a0<strong>\u5ba1\u6821\uff1a<\/strong>ZXY<\/section>\n<section><strong>DOI:<\/strong><strong>\u00a0<\/strong>10.1126\/sciadv.ado7438<\/section>\n<section><strong>Link:<\/strong>\u00a0https:\/\/doi.org\/10.1126\/sciadv.ado7438<\/section>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5206\u4eab\u4e00\u7bc7\u8fd1\u671f\u53d1\u8868Science Advances\u4e0a\u7684\u6587\u7ae0\uff0c\u9898\u76ee\u4e3a\u201cTwo-birds-one-stone\u201d\u00a0o 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