{"id":52172,"date":"2024-08-27T08:46:10","date_gmt":"2024-08-27T00:46:10","guid":{"rendered":"https:\/\/www.chemhui.com\/?p=52172"},"modified":"2024-08-18T19:46:58","modified_gmt":"2024-08-18T11:46:58","slug":"nat-chem-biol-%e5%bc%a0%e8%bf%aa%e3%80%81%e9%ab%98%e6%99%8b%e5%90%9b%e7%ad%89%e5%90%88%e4%bd%9c%e5%8f%91%e7%8e%b0%e8%b5%96%e6%b0%a8%e9%85%b8l-%e4%b9%b3%e9%85%b0%e5%8c%96%e6%98%af%e7%b3%96","status":"publish","type":"post","link":"http:\/\/www.chemhui.com\/nat-chem-biol-%e5%bc%a0%e8%bf%aa%e3%80%81%e9%ab%98%e6%99%8b%e5%90%9b%e7%ad%89%e5%90%88%e4%bd%9c%e5%8f%91%e7%8e%b0%e8%b5%96%e6%b0%a8%e9%85%b8l-%e4%b9%b3%e9%85%b0%e5%8c%96%e6%98%af%e7%b3%96\/","title":{"rendered":"Nat. Chem. Biol. | \u5f20\u8fea\u3001\u9ad8\u664b\u541b\u7b49\u5408\u4f5c\u53d1\u73b0\u8d56\u6c28\u9178L-\u4e73\u9170\u5316\u662f\u7cd6\u9175\u89e3\u8bf1\u5bfc\u7684\u4e3b\u8981\u4e73\u9170\u5316\u5f62\u5f0f"},"content":{"rendered":"<section>\u5206\u4eab\u4e00\u7bc7\u53d1\u8868\u5728Nature Chemical Biology \u4e0a\u7684\u6587\u7ae0\u201cLysine l-lactylation is the dominant lactylation isomer induced by glycolysis\u201d\uff0c\u901a\u8baf\u4f5c\u8005\u662f\u6765\u81ea\u829d\u52a0\u54e5\u5927\u5b66\u7684\u8d75\u82f1\u660e\u6559\u6388\u3001\u5a01\u65af\u5eb7\u661f\u5927\u5b66\u9ea6\u8fea\u900a\u5206\u6821\u7684\u674e\u7075\u519b\u6559\u6388\u3001\u56db\u5ddd\u5927\u5b66\u7684\u6234\u4f26\u6cbb\u6559\u6388\u4ee5\u53ca\u5317\u4eac\u5927\u5b66\u7684\u5f20\u8fea\u6559\u6388\u3002\u7814\u7a76\u65b9\u5411\u5305\u62ec\u86cb\u767d\u7ec4\u5b66\u3001\u795e\u7ecf\u80bd\u7ec4\u5b66\u3001\u86cb\u767d\u7ffb\u8bd1\u540e\u4fee\u9970\u7b49\u3002<strong>\u5728\u672c\u6587\u4e2d\uff0c\u4f5c\u8005\u53d1\u5c55\u4e86\u533a\u5206\u4e73\u9170\u5316\u4fee\u9970\u5f02\u6784\u4f53\u7684\u65b9\u6cd5\uff0c\u5e76\u8bc1\u660e\u4e86L-\u4e73\u9170\u5316\u662f\u7cd6\u9175\u89e3\u8bf1\u5bfc\u7684\u4e3b\u8981\u4e73\u9170\u5316\u5f02\u6784\u4f53\u3002<\/strong><\/section>\n<p>&nbsp;<\/p>\n<section><\/section>\n<section><img decoding=\"async\" title=\"1\" src=\"https:\/\/17332.seohost.cn\/storage\/17332\/article\/20240727\/1722064451354140.png\" alt=\"1\" \/><\/section>\n<section>\u4e73\u9170\u5316\u4fee\u9970\uff08KL-la\uff09\u662f\u4e00\u79cd\u7531L\u578b\u4e73\u9178\u6240\u4ecb\u5bfc\u7684\u86cb\u767d\u7ffb\u8bd1\u540e\u4fee\u9970\u3002\u5728\u7ec6\u80de\u4e2d\uff0c\u8fd9\u79cd\u4fee\u9970\u5177\u6709\u53e6\u5916\u4e24\u79cd\u540c\u5206\u5f02\u6784\u4f53\uff0c\u5206\u522b\u662f\u7531\u7532\u57fa\u4e59\u4e8c\u919b\uff08MGO\uff09\u76f4\u63a5\u4e0eLys\u53cd\u5e94\u751f\u6210\u7684Kce\u4fee\u9970\uff0c\u4ee5\u53caMGO\u5148\u4e0eGSH\u4e2d\u7684\u534a\u80f1\u6c28\u9178\u6b8b\u57fa\u53cd\u5e94\u751f\u6210LGSH\u4e2d\u95f4\u4f53\uff0c\u518d\u8f6c\u79fb\u5230Lys\u4e0a\u5f62\u6210\u7684KD-la\u4fee\u9970\u3002\u800c\u8fd9\u4e09\u79cd\u4fee\u9970\u5728\u6c83\u4f2f\u683c\u6548\u5e94\u4e2d\u7684\u4f5c\u7528\u4ee5\u53ca\u6838\u5b9a\u4f4d\u7b49\u65b9\u9762\u7684\u7814\u7a76\u4e2d\u7ecf\u5e38\u88ab\u6df7\u6dc6\u3002\u56e0\u6b64\uff0c\u4f5c\u8005\u5206\u522b\u53d1\u5c55\u4e86\u6297\u4f53\u5bcc\u96c6\u6cd5\u548c\u5316\u5b66\u884d\u751f\u6cd5\u4e24\u79cd\u7b56\u7565\u6765\u533a\u5206\u8fd9\u4e09\u79cd\u4fee\u9970\u5f62\u5f0f\uff0c\u5e76\u53d1\u73b0KL-la\u662f\u7cd6\u9175\u89e3\u548c\u6c83\u4f2f\u683c\u6548\u5e94\u7684\u4e3b\u8981\u54cd\u5e94\u8005\u3002<\/section>\n<section><img decoding=\"async\" title=\"2\" src=\"https:\/\/17332.seohost.cn\/storage\/17332\/article\/20240727\/1722064459995277.png\" alt=\"2\" \/><\/section>\n<section>\u9996\u5148\uff0c\u4f5c\u8005\u5206\u522b\u5236\u5907\u4e86KL-la\u3001KD-la\u548cKce\u4e09\u79cd\u4fee\u9970\u7684\u5355\u514b\u9686\u6297\u4f53\uff0c\u5e76\u91c7\u7528WB\u5b9e\u9a8c\u7ed3\u679c\u9a8c\u8bc1\u4e86\u8fd9\u4e09\u79cd\u6297\u4f53\u90fd\u5177\u6709\u8f83\u9ad8\u7684\u7279\u5f02\u6027\u3002\u968f\u540e\uff0c\u4f5c\u8005\u5e0c\u671b\u91c7\u7528\u53e6\u4e00\u79cd\u6b63\u4ea4\u7684\u7b56\u7565\u6765\u533a\u5206\u8fd9\u4e09\u79cd\u4fee\u9970\u3002<span class=\"wx_search_keyword_wrap\">HPLC<\/span>\u68c0\u6d4b\u7ed3\u679c\u8868\u660eKce\u4e0eKla\u5728\u8272\u8c31\u4e0a\u4fdd\u7559\u65f6\u95f4\u4e0d\u540c\uff0c\u53ef\u4ee5\u5b9e\u73b0\u5206\u79bb\u3002\u800cKD-la\u548cKL-la\u7531\u4e8e\u4ec5\u6709\u4e00\u4e2a\u624b\u6027\u4e2d\u5fc3\u4e0d\u540c\u96be\u4ee5\u5728\u53cd\u76f8\u67f1\u4e0a\u5b9e\u73b0\u5206\u79bb\u3002\u4e3a\u89e3\u51b3\u8fd9\u4e00\u95ee\u9898\uff0c\u4f5c\u8005\u91c7\u7528Mosher\u8bd5\u5242\u4e0e\u4e73\u9170\u5316Lys\u53cd\u5e94\uff0c\u5e94\u8be5\u662f\u901a\u8fc7\u884d\u751f\u5316\u653e\u5927\u624b\u6027\u4e2d\u5fc3\u7684\u7ed3\u6784\u5dee\u5f02\u4f7f\u5f97\u4e8c\u8005\u5728\u8272\u8c31\u4e0a\u7684\u4fdd\u7559\u65f6\u95f4\u4ea7\u751f\u5dee\u5f02\uff0c\u4ed6\u4eec\u4e5f\u8bc1\u660e\u4e86\u53cd\u5e94\u540e\u786e\u5b9e\u80fd\u591f\u533a\u5206KD-la\u548cKL-la\u3002<\/section>\n<section><img decoding=\"async\" title=\"3\" src=\"https:\/\/17332.seohost.cn\/storage\/17332\/article\/20240727\/1722064470195082.png\" alt=\"3\" \/><\/section>\n<section>\u63a5\u4e0b\u6765\uff0c\u4e3a\u8bc1\u660e\u7ec4\u86cb\u767d\u4e0a\u7684\u4e3b\u8981\u4fee\u9970\u5f62\u5f0f\uff0c\u4f5c\u8005\u91c7\u7528\u91cd\u6807Lys\u57f9\u517b\u7ec6\u80de\uff0c\u83b7\u5f97\u91cd\u6807\u7684\u7ec4\u86cb\u767d\uff0c\u5e76\u63ba\u5165\u8f7b\u6807\u7684KL-la\u3001KD-la\u548cKce\u6807\u51c6\u54c1\u8fdb\u884c\u5316\u5b66\u884d\u751f\u548cLC-MS\/MS\u68c0\u6d4b\u3002\u4ed6\u4eec\u53d1\u73b0\u5185\u6e90\u4fee\u9970\u4e0eKL-la\u5171\u6d41\u51fa\uff0c\u8868\u660e\u7ec6\u80de\u4e2d\u7ec4\u86cb\u767d\u4e0a\u7684\u4e73\u9170\u5316\u4fee\u9970\u4e3aKL-la\u3002\u6b64\u5916\uff0c\u4e3a\u7814\u7a76\u54cd\u5e94\u7cd6\u9175\u89e3\u8fc7\u7a0b\u7684\u4e3b\u8981\u4fee\u9970\u5f62\u5f0f\uff0c\u4f5c\u8005\u4e5f\u91c7\u7528\u4e86\u9ad8\u4f4e\u6d53\u5ea6\u8461\u8404\u7cd6\u5904\u7406\u7ec6\u80de\uff0c\u6df7\u5408\u8f7b\/\u91cd\u6807\u7684\u7ec4\u86cb\u767d\uff0c\u5e76\u91c7\u7528\u9176\u5207\u52a0PTM\u7279\u5f02\u6027\u6297\u4f53\u5bcc\u96c6\u7684\u65b9\u5f0f\u6765\u68c0\u6d4b\u8fd9\u4e09\u79cd\u4fee\u9970\u4e30\u5ea6\u7684\u53d8\u5316\u3002\u4ed6\u4eec\u53d1\u73b0\u5728\u9ad8\u7cd6\u6761\u4ef6\u4e0bKL-la\u7684\u542b\u91cf\u4e0a\u5347\uff0c\u4e14\u5347\u9ad8\u7684\u4f4d\u70b9\u4f4d\u4e8e\u6838\u5fc3\u7ec4\u86cb\u767d\uff0c\u800c\u53e6\u4e24\u79cd\u4fee\u9970\u5f62\u5f0f\u6ca1\u6709\u660e\u663e\u53d8\u5316\u3002\u4ed6\u4eec\u4e5f\u901a\u8fc7WB\u5b9e\u9a8c\u53d1\u73b0\u5728\u6291\u5236\u7cd6\u9175\u89e3\u9014\u5f84\u540eKL-la\u7684\u4fe1\u53f7\u4e0b\u964d\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\u4e86KL-la\u4e3b\u8981\u53d7\u5230\u7cd6\u9175\u89e3\u8fc7\u7a0b\u7684\u8c03\u63a7\u3002\u6700\u7ec8\uff0c\u4f5c\u8005\u4e5f\u901a\u8fc7\u52a0\u5165\u91cd\u6807L\u578b\u4e73\u9178\u6216\u91cd\u6807<span class=\"wx_search_keyword_wrap\">D\u8461\u8404\u7cd6<\/span>\uff0c\u91c7\u7528\u540c\u4f4d\u7d20\u793a\u8e2a\u7684\u65b9\u5f0f\u8bc1\u660e\u4e86\u7cd6\u9175\u89e3\u6240\u4ecb\u5bfc\u7684KL-la\u662f\u7531\u4e73\u9170CoA\u6240\u4ecb\u5bfc\u7684\u3002<\/section>\n<section><img decoding=\"async\" title=\"7\" src=\"https:\/\/17332.seohost.cn\/storage\/17332\/article\/20240727\/1722064484513087.png\" alt=\"7\" \/><\/section>\n<section>\u603b\u7684\u6765\u8bf4\uff0c\u5728\u672c\u6587\u4e2d\u4f5c\u8005\u5206\u522b\u91c7\u7528\u7279\u5f02\u6027\u6297\u4f53\u4ee5\u53ca\u5316\u5b66\u884d\u751f\u8fd9\u4e24\u79cd\u6b63\u4ea4\u7684\u7b56\u7565\u5b9e\u73b0\u4e86L\u4e73\u9170\u5316\u4fee\u9970\u53ca\u5176\u540c\u5206\u5f02\u6784\u4f53\u7684\u533a\u5206\uff0c\u5e76\u8bc1\u660e\u4e86KL-la\u662f\u54cd\u5e94\u7cd6\u9175\u89e3\u8fc7\u7a0b\u7684\u4e3b\u8981\u4fee\u9970\u7c7b\u578b\u3002<\/section>\n<section>\u672c\u6587\u5171\u540c\u7b2c\u4e00\u4f5c\u8005<strong>\u9ad8\u664b\u541b\u535a\u58eb<\/strong>\u73b0\u4efb\u804c\u4e8e\u5317\u4eac\u5927\u5b66\u6df1\u5733\u7814\u7a76\u751f\u9662\uff0c\u4efb\u52a9\u7406\u6559\u6388\/\u7279\u8058\u7814\u7a76\u5458\uff0c\u8bfe\u9898\u7ec4\u957f\uff0c\u535a\u58eb\u751f\u5bfc\u5e08\u3002\u9ad8\u664b\u541b\u535a\u58eb\u6bd5\u4e1a\u4e8e\u5317\u4eac\u5927\u5b66\u524d\u6cbf\u4ea4\u53c9\u5b66\u79d1\u7814\u7a76\u9662\uff0c\u5bfc\u5e08\u4e3a\u738b\u521d\u6559\u6388\uff0c\u535a\u58eb\u671f\u95f4\u53d1\u5c55\u4e86\u4e00\u7cfb\u5217\u521b\u65b0\u7684\u86cb\u767d\u8d28\u7ec4\u5b66\u65b9\u6cd5\uff0c\u4ee5\u63d0\u9ad8\uff08\u5316\u5b66\uff09\u86cb\u767d\u8d28\u7ec4\u5b66\u4e2d\u7684\u9274\u5b9a\u7075\u654f\u5ea6\u548c\u5b9a\u91cf\u6548\u7387\u3002\u968f\u540e\u5728\u829d\u52a0\u54e5\u5927\u5b66\u8fdb\u884c\u535a\u58eb\u540e\u7814\u7a76\uff0c\u5408\u4f5c\u5bfc\u5e08\u4e3a\u4e16\u754c\u77e5\u540d\u86cb\u767d\u8d28\u7ec4\u5b66\u4e13\u5bb6\u8d75\u82f1\u660e\u6559\u6388\uff0c\u4ece\u4e8b\u7ec4\u86cb\u767d\u7ffb\u8bd1\u540e\u4fee\u9970\u76f8\u5173\u7814\u7a76\uff0c\u671f\u95f4\u5de5\u4f5c\u4e3a\u4e73\u9170\u5316\u7814\u7a76\u9886\u57df\u5960\u5b9a\u4e86\u91cd\u8981\u57fa\u7840\u3002\u9ad8\u664b\u541b\u535a\u58eb\u4ee5\uff08\u5171\u540c\uff09\u7b2c\u4e00\u4f5c\u8005\u5728Nature Chemical Biology\uff0c<span class=\"wx_search_keyword_wrap\">Science Advances<\/span>\uff0cACS Central Science\u7b49\u9ad8\u6c34\u5e73\u6742\u5fd7\u53d1\u8868\u8bba\u6587\u591a\u7bc7\uff0c\u4f5c\u4e3a\u91cd\u8981\u53c2\u4e0e\u4eba\u5728Nature,\u00a0<span class=\"wx_search_keyword_wrap\">Nature Communications<\/span>\u7b49\u6742\u5fd7\u4e0a\u5408\u4f5c\u53d1\u8868\u8bba\u6587\u5341\u4f59\u7bc7\u3002<\/section>\n<section>\u9ad8\u664b\u541b\u8bfe\u9898\u7ec4\u5c06\u5728\u5316\u5b66\u751f\u7269\u5b66\u3001\u86cb\u767d\u8d28\u7ec4\u5b66\u3001\u86cb\u767d\u8d28\u7ffb\u8bd1\u540e\u4fee\u9970\u3001\u8868\u89c2\u9057\u4f20\u5b66\u548c\u764c\u75c7\u751f\u7269\u5b66\u7b49\u591a\u4e2a\u4ea4\u53c9\u9886\u57df\u5f00\u5c55\u7814\u7a76\u5de5\u4f5c\u3002\u8bfe\u9898\u7ec4\u81f4\u529b\u4e8e\u5f00\u53d1\u521b\u65b0\u7684\u86cb\u767d\u8d28\u7ec4\u5b66\u6280\u672f\uff0c\u5e76\u7ed3\u5408\u524d\u6cbf\u7684\u5316\u5b66\u548c\u5206\u5b50\u751f\u7269\u5b66\u5de5\u5177\uff0c\u63a2\u7d22\u86cb\u767d\u8d28\u7ffb\u8bd1\u540e\u4fee\u9970\u53c2\u4e0e\u7ec6\u80de\u8fc7\u7a0b\u548c\u75be\u75c5\u53d1\u75c5\u7684\u529f\u80fd\u673a\u5236\uff0c\u4ee5\u8bc6\u522b\u75be\u75c5\u6807\u7684\u7269\uff0c\u5e76\u53d1\u73b0\u65b0\u7684\u6cbb\u7597\u9776\u70b9\u548c\u836f\u7269\u3002<strong>\u8bfe\u9898\u7ec4\u8bda\u8058\u5316\u5b66\u751f\u7269\u5b66\u3001\u86cb\u767d\u8d28\u7ec4\u5b66\u3001\u6709\u673a\u5316\u5b66\u3001\u836f\u7269\u5316\u5b66\u3001\u764c\u75c7\u751f\u7269\u5b66\u53ca\u76f8\u5173\u65b9\u5411\u7684\u535a\u58eb\u540e2\u540d\uff08\u5e74\u85aa\u4e0d\u4f4e\u4e8e40\u4e07\/\u5e74+\u6821\u5185\u516c\u5bd3\uff09\uff0c\u6709\u610f\u8005\u8bf7\u8054\u7cfb\u9ad8\u664b\u541b\u535a\u58ebgaojinjun@pku.edu.cn\u3002<\/strong><strong>\u8be6\u7ec6\u62db\u8058\u4fe1\u606f\u8bf7\u89c1\u8bfe\u9898\u7ec4\u7f51\u7ad9\uff1a<br \/>\n<\/strong><strong>https:\/\/web.pkusz.edu.cn\/jinjungaolab\/opening\/<\/strong><\/section>\n<section><\/section>\n<section>\u672c\u6587\u4f5c\u8005\uff1aWYQ<\/section>\n<section>\u8d23\u4efb\u7f16\u8f91\uff1aWYQ WFZ<\/section>\n<section>\u539f\u6587\u94fe\u63a5\uff1ahttps:\/\/www.nature.com\/articles\/s41589-024-01680-8<\/section>\n<section>\u6587\u7ae0\u5f15\u7528\uff1a10.1038\/s41589-024-01680-8<\/section>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5206\u4eab\u4e00\u7bc7\u53d1\u8868\u5728Nature Chemical Biology \u4e0a\u7684\u6587\u7ae0\u201cLysine l-lactylatio [&hellip;]<\/p>\n","protected":false},"author":326,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[],"class_list":["post-52172","post","type-post","status-publish","format-standard","hentry","category-tuijianyuedu"],"_links":{"self":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/52172","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/users\/326"}],"replies":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/comments?post=52172"}],"version-history":[{"count":1,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/52172\/revisions"}],"predecessor-version":[{"id":52173,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/52172\/revisions\/52173"}],"wp:attachment":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/media?parent=52172"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/categories?post=52172"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/tags?post=52172"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}