{"id":51848,"date":"2024-07-14T08:35:40","date_gmt":"2024-07-14T00:35:40","guid":{"rendered":"https:\/\/www.chemhui.com\/?p=51848"},"modified":"2024-07-05T09:36:04","modified_gmt":"2024-07-05T01:36:04","slug":"nat-chem-biol-%e4%bb%8e%e5%a4%b4%e8%ae%be%e8%ae%a1%e7%9a%84%e5%8d%b7%e6%9b%b2%e8%9e%ba%e6%97%8b%e5%bc%80%e5%85%b3%e6%8e%a7%e5%88%b6kinesin-1%e7%9a%84%e6%9e%84%e8%b1%a1","status":"publish","type":"post","link":"http:\/\/www.chemhui.com\/nat-chem-biol-%e4%bb%8e%e5%a4%b4%e8%ae%be%e8%ae%a1%e7%9a%84%e5%8d%b7%e6%9b%b2%e8%9e%ba%e6%97%8b%e5%bc%80%e5%85%b3%e6%8e%a7%e5%88%b6kinesin-1%e7%9a%84%e6%9e%84%e8%b1%a1\/","title":{"rendered":"Nat. Chem. Biol. | \u4ece\u5934\u8bbe\u8ba1\u7684\u5377\u66f2\u87ba\u65cb\u5f00\u5173\u63a7\u5236kinesin-1\u7684\u6784\u8c61"},"content":{"rendered":"

\u5206\u4eab\u4e00\u7bc7\u53d1\u8868\u5728Nat.\u00a0Chem. Biol.\u4e0a\u7684\u6587\u7ae0\uff0c\u9898\u76ee\u4e3a\u201cA de novo designed coiled coil-based switch regulates the microtubule motor kinesin-1\u201d\u3002\u901a\u8baf\u4f5c\u8005\u4e3a\u5e03\u91cc\u65af\u6258\u5927\u5b66\u7684Derek N. Woolfson, Mark P. Dodding\u548cJessica A. Cross\u3002\u5176\u4e2d\uff0cWoolfson\u6559\u6388\u7684\u7814\u7a76\u65b9\u5411\u4e3a\u86cb\u767d\u8d28\u6298\u53e0\u53ca\u86cb\u767d\u8bbe\u8ba1\u3002<\/p>\n

\u8bbe\u8ba1\u5177\u6709\u6784\u8c61\u5f00\u5173\u529f\u80fd\u7684\u86cb\u767d\u662f\u5177\u6709\u6311\u6218\u7684\u3002\u4f8b\u5982\uff0c\u4ece\u5934\u8bbe\u8ba1\u7684\u86cb\u767d\u901a\u5e38\u5177\u6709\u6781\u7aef\u7a33\u5b9a\u7684\u7ed3\u6784\uff0c\u5f80\u5f80\u4e0d\u50cf\u5929\u7136\u86cb\u767d\u4e00\u6837\u5177\u6709\u6784\u8c61\u95f4\u8f6c\u6362\u7684\u52a8\u6001\u80fd\u529b\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u86cb\u767d\u7684\u6784\u8c61\u8f6c\u6362\u5728\u7ec6\u80de\u9aa8\u67b6\u8fd0\u52a8\u86cb\u767d\u4e2d\u5c24\u4e3a\u91cd\u8981\uff0c\u4f8b\u5982\uff0ckinesin-1\u662f\u4e00\u79cd\u4ee5\u5f02\u56db\u805a\u4f53\u5f62\u5f0f\u5b58\u5728\u7684\u5fae\u7ba1\u9a6c\u8fbe\uff0c\u5f53\u65e0\u8d27\u7269\u7ed3\u5408\u65f6\uff0c\u5176\u5904\u4e8e\u4e00\u79cd\u81ea\u6291\u5236\u6784\u8c61\u3002\u6700\u8fd1\uff0c\u4f5c\u8005\u56e2\u961f\u89e3\u6790\u4e86kinesin-1\u81ea\u6291\u5236\u6784\u8c61\u7684\u7ed3\u6784\uff0c\u7ed3\u679c\u63ed\u793a\u4e86\u86cb\u767d\u4e24\u4e2aCC\u7ed3\u6784\u57df\u95f4\u5b58\u5728\u7684\u67d4\u6027\u94f0\u94fe\u7ed3\u6784\uff0c\u5373\u8098\u72b6\u7ed3\u6784\uff08elbow\uff09\uff0c\u8be5\u533a\u57df\u5bf9\u590d\u5408\u4f53\u4ece\u6298\u53e0\uff08\u03bb\uff09\u6784\u8c61\u5230\u6253\u5f00\u6784\u8c61\u4e4b\u95f4\u7684\u8f6c\u53d8\u81f3\u5173\u91cd\u8981\u3002\u672c\u6587\u4e2d\uff0c\u4f5c\u8005\u5c1d\u8bd5\u901a\u8fc7\u4ece\u5934\u8bbe\u8ba1\u65b9\u6cd5\u5728\u8be5\u7ed3\u6784\u57df\u5904\u5f15\u5165\u6784\u8c61\u5f00\u5173\uff0c\u4ece\u800c\u5b9e\u73b0\u5bf9kinesin-1\u6784\u8c61\u7684\u7075\u6d3b\u63a7\u5236\u3002<\/p>\n

\"1\"<\/p>\n

\u4e3a\u4e86\u5b9e\u73b0\u8fd9\u4e00\u76ee\u7684\uff0c\u4f5c\u8005\u8ba1\u5212\u5411\u86cb\u767d\u7684CC2\/CC3\u7ed3\u6784\u57df\u95f4\u5f15\u5165\u91cd\u65b0\u8bbe\u8ba1\u7684elbow\u7ed3\u6784\u57df\uff08pA\uff09\uff0c\u5b83\u53ef\u4ee5\u4e0e\u4ece\u5934\u8bbe\u8ba1\u7684\u591a\u80bd\u914d\u4f53\uff08pB\uff09\u7ed3\u5408\uff0c\u4ece\u800c\u53d1\u751f\u6784\u8c61\u8f6c\u53d8\u3002\u4f5c\u8005\u9996\u5148\u7528AlphaFold2\u9884\u6d4b\u4e86\u91ce\u751f\u578bkinesin\u7684\u7ed3\u6784\uff0c\u7ed3\u679c\u663e\u793aAF2\u80fd\u591f\u53ef\u9760\u5730\u6355\u6349\u5230kinesin WT\u7684\u4e24\u6001\u5e73\u8861\u3002\u800c\u5bf9\u4e8ekinesin\u0394Elbow\uff0cAF2\u5219\u7ed9\u51fa\u5b8c\u5168\u6253\u5f00\u7684\u6784\u8c61\u3002\u8fd9\u4e9b\u9884\u6d4b\u90fd\u901a\u8fc7\u4f53\u79ef\u6392\u963b\u8272\u8c31\uff08SEC\uff09\u5b9e\u9a8c\u5f97\u5230\u4e86\u9a8c\u8bc1\u3002<\/p>\n

\u63a5\u4e0b\u6765\uff0c\u4f5c\u8005\u5c1d\u8bd5\u901a\u8fc7\u4ece\u5934\u8bbe\u8ba1elbow\u7ed3\u6784\u57df\u5b9e\u73b0\u5bf9kinesin\u6784\u8c61\u7684\u9759\u6001\u63a7\u5236\u3002\u4f5c\u8005\u5229\u7528\u5176\u6b64\u524d\u5f00\u53d1\u7684\u53ef\u89c6\u5316\u5377\u66f2\u87ba\u65cb\u7ed3\u6784\u57df\u7684\u8f6f\u4ef6Socket2\uff0c\u5206\u6790\u4e86kinesin\u5728\u03bb\u6784\u8c61\u65f6elbow\u7ed3\u6784\u57df\u4e2d\u5b58\u5728\u7684\u5377\u66f2\u87ba\u65cb\u3001\u87ba\u65cb\u95f4\u548c\u51f9\u51f8\uff08knobs-into-holes\uff09\u76f8\u4e92\u4f5c\u7528\u3002\u7ed3\u679c\u63d0\u793a\u5176\u4e2d5\u4e2a\u6b8b\u57fa\u7684\u53bb\u9664\u53ef\u6709\u6548\u5730\u7834\u574felbow\u7ed3\u6784\u57df\u7684\u6784\u8c61\u7075\u6d3b\u6027\u3002AF2\u9884\u6d4b\u548cSEC\u5b9e\u9a8c\u90fd\u8bc1\u5b9e\u4e86\u8fd9\u79cd\u53d8\u4f53\uff08Elbow Lock\uff09\u88ab\u9501\u5b9a\u5728\u03bb\u6784\u8c61\u3002\u968f\u540e\uff0c\u4f5c\u8005\u4e5f\u6210\u529f\u7528\u4ece\u5934\u8bbe\u8ba1\u7684elbow\u7ed3\u6784\u57df\uff08EL-CC-Di-IR\uff09\u5c06\u86cb\u767d\u9501\u5b9a\u5728\u5f00\u653e\u6784\u8c61\u3002<\/p>\n

\"7\"<\/p>\n

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\u6700\u540e\uff0c\u4f5c\u8005\u5728\u6d3b\u7ec6\u80de\u5185\u6d4b\u8bd5\u4e86\u8fd9\u79cd\u4ece\u5934\u8bbe\u8ba1\u80bd\u8bf1\u5bfc\u7684\u6784\u8c61\u8f6c\u6362\u662f\u5426\u80fd\u5b9e\u73b0\u5bf9kinesin\u7684\u53d8\u6784\u6fc0\u6d3b\u3002\u6210\u50cf\u7ed3\u679c\u663e\u793a\uff0c\u5904\u4e8e\u03bb\u6784\u8c61\u7684\u8367\u5149\u6807\u8bb0kinesin\u5728\u80de\u8d28\u5185\u5f25\u6563\u5206\u5e03\uff0c\u800c\u5904\u4e8e\u5f00\u653e\u6784\u8c61\u7684kinesin\u5219\u5177\u6709\u5fae\u7ba1\u5b9a\u4f4d\u3002\u91cd\u8981\u7684\u662f\uff0c\u5728\u5177\u6709\u7a7f\u819c\u80fd\u529b\u7684\u80bdpB\u5904\u7406\u4e0b\uff0cEL-pA-Ala\u7684\u4e9a\u7ec6\u80de\u5b9a\u4f4d\u53d1\u751f\u4e86\u663e\u8457\u6539\u53d8\uff0c\u63d0\u793a\u5176\u5728\u7ec6\u80de\u5185\u7684\u53d8\u6784\u6fc0\u6d3b\u3002<\/p>\n

\u672c\u6587\u4f5c\u8005\uff1aTYC<\/p>\n

\u8d23\u4efb\u7f16\u8f91\uff1aZF<\/p>\n

\u539f\u6587\u94fe\u63a5\uff1ahttps:\/\/www.nature.com\/articles\/s41589-024-01640-2<\/p>\n

\u6587\u7ae0\u5f15\u7528\uff1aDOI: 10.1038\/s41589-024-01640-2<\/p>\n","protected":false},"excerpt":{"rendered":"

\u5206\u4eab\u4e00\u7bc7\u53d1\u8868\u5728Nat.\u00a0Chem. Biol.\u4e0a\u7684\u6587\u7ae0\uff0c\u9898\u76ee\u4e3a\u201cA de novo designed coil […]<\/p>\n","protected":false},"author":326,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[],"class_list":["post-51848","post","type-post","status-publish","format-standard","hentry","category-tuijianyuedu"],"_links":{"self":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/51848","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/users\/326"}],"replies":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/comments?post=51848"}],"version-history":[{"count":1,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/51848\/revisions"}],"predecessor-version":[{"id":51849,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/51848\/revisions\/51849"}],"wp:attachment":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/media?parent=51848"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/categories?post=51848"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/tags?post=51848"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}