{"id":51842,"date":"2024-07-13T08:51:38","date_gmt":"2024-07-13T00:51:38","guid":{"rendered":"https:\/\/www.chemhui.com\/?p=51842"},"modified":"2024-07-04T09:52:16","modified_gmt":"2024-07-04T01:52:16","slug":"nat-commun-%e9%ab%98%e5%8e%8b%e6%b0%a7%e5%a2%9e%e5%bc%ba%e8%82%bf%e7%98%a4%e6%b8%97%e9%80%8f%e5%92%8c%e5%b7%a5%e7%a8%8b%e7%bb%86%e8%8f%8c%e7%9a%84%e7%a7%af%e7%b4%af%ef%bc%8c%e7%94%a8%e4%ba%8e","status":"publish","type":"post","link":"http:\/\/www.chemhui.com\/nat-commun-%e9%ab%98%e5%8e%8b%e6%b0%a7%e5%a2%9e%e5%bc%ba%e8%82%bf%e7%98%a4%e6%b8%97%e9%80%8f%e5%92%8c%e5%b7%a5%e7%a8%8b%e7%bb%86%e8%8f%8c%e7%9a%84%e7%a7%af%e7%b4%af%ef%bc%8c%e7%94%a8%e4%ba%8e\/","title":{"rendered":"Nat. Commun. | \u9ad8\u538b\u6c27\u589e\u5f3a\u80bf\u7624\u6e17\u900f\u548c\u5de5\u7a0b\u7ec6\u83cc\u7684\u79ef\u7d2f\uff0c\u7528\u4e8e\u534f\u540c\u5149\u70ed\u514d\u75ab\u6cbb\u7597"},"content":{"rendered":"<section>\u5206\u4eab\u4e00\u7bc7\u53d1\u8868\u5728Nature Communication\u4e0a\u7684\u6587\u7ae0\uff0c\u9898\u76ee\u4e3a\u201cHyperbaric oxygen enhances tumor penetration and accumulation of engineered bacteria for synergistic photothermal immunotherapy\u201d\u3002\u5728\u672c\u6587\u4e2d\uff0c\u4f5c\u8005\u91c7\u7528cypate\u5206\u5b50\u4fee\u9970\u5927\u80a0\u83cc\u6746Nissle1917(EcN)\uff0c\u4ea7\u751f\u7528\u4e8e\u5149\u70ed\u7597\u6cd5\u7684EcN-cypate\uff0c\u968f\u540e\u53ef\u8bf1\u5bfc\u514d\u75ab\u539f\u6027\u7ec6\u80de\u6b7b\u4ea1(ICD)\uff1b\u540c\u65f6\u91c7\u7528\u9ad8\u538b\u6c27(<span class=\"wx_search_keyword_wrap\">HBO<\/span>)\u975e\u4fb5\u5165\u6027\u7597\u6cd5\u4ee5\u9ad8\u6548\u6d88\u8017\u81f4\u5bc6\u7684\u7ec6\u80de\u5916\u95f4\u8d28\uff0c\u4ece\u800c\u589e\u52a0\u80bf\u7624\u5185\u7ec6\u83cc\u7684\u79ef\u7d2f\uff0c\u4ece\u800c\u5b9e\u73b0\u7406\u60f3\u7684\u80bf\u7624\u6839\u9664\u3002<\/p>\n<\/section>\n<p>&nbsp;<\/p>\n<section><img decoding=\"async\" title=\"1\" src=\"https:\/\/17332.seohost.cn\/storage\/17332\/article\/20240701\/1719799215481517.png\" alt=\"1\" 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Nissle 1917(<span class=\"wx_search_keyword_wrap\">EcN<\/span>)\u4f5c\u4e3a\u6a21\u578b\u7ec6\u83cc\u6765\u7814\u7a76\u9ad8\u538b\u6c27\u5bf9\u80bf\u7624\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u7ec6\u83cc\u6d3b\u6027\u7684\u5f71\u54cd\u3002<\/p>\n<\/section>\n<section><img decoding=\"async\" title=\"2\" src=\"https:\/\/17332.seohost.cn\/storage\/17332\/article\/20240701\/1719799227467285.webp\" alt=\"2\" \/><\/section>\n<section>\u56fe1<\/p>\n<\/section>\n<section>\u9ad8\u538b\u6c27\u53ef\u4ee5\u589e\u52a0\u8840\u6db2\u548c\u7ec4\u7ec7\u4e2d\u7684\u6c27\u6c14\u538b\u529b\uff0c\u8fd9\u53ef\u80fd\u5f15\u5bfc\u517c\u6027\u538c\u6c27\u83cc(EcN)\u5728<span class=\"wx_search_keyword_wrap\">\u9ad8\u538b\u6c27\u6cbb\u7597<\/span>\u8fc7\u7a0b\u4e2d\u5bf9\u4f4e\u6c27\u80bf\u7624\u8868\u73b0\u51fa\u6539\u5584\u7684\u9776\u5411\u80fd\u529b\uff1b\u53e6\u4e00\u65b9\u9762\uff0cHBO\u4e5f\u53ef\u4ee5\u6d88\u8017\u81f4\u5bc6\u7684ECM\uff0c\u4ee5\u589e\u5f3a\u80bf\u7624\u5185\u6e17\u900f\u548cECN\u7684\u79ef\u7d2f\u3002\u5982\u56fe1a\u6240\u793a\uff0c\u901a\u8fc7\u9170\u80fa\u5316\u53cd\u5e94\uff0c\u7528\u5149\u70ed\u8367\u5149\u56e2(cypate)\u4fee\u9970EcN\u7684\u8868\u9762\uff0c\u5f97\u5230EcN-cypate\u3002\u9ad8\u538b\u6c27\u6cbb\u7597\u540e\u4fc3\u8fdb\u4e86EcN-cypate\u5728\u80bf\u7624\u7ec4\u7ec7\u4e2d\u7684\u79ef\u7d2f\u3002\u5728\u8fd1\u7ea2\u5916(NIR)\u6fc0\u5149\u7167\u5c04\u4e0b\uff0cEcNcypate\u5b9e\u73b0PTT\u5e76\u89e6\u53d1\u514d\u75ab\u539f\u6027\u7ec6\u80de\u6b7b\u4ea1(<span class=\"wx_search_keyword_wrap\">ICD<\/span>)\uff0c\u5176\u5f15\u53d1\u5168\u8eab\u6027\u514d\u75ab\u5e94\u7b54\uff0c\u5982\u6811\u7a81\u72b6\u7ec6\u80de(DC)\u6210\u719f\u4ee5\u6839\u9664\u80bf\u7624(\u56fe1b)\u3002<\/p>\n<\/section>\n<section><img decoding=\"async\" title=\"3\" src=\"https:\/\/17332.seohost.cn\/storage\/17332\/article\/20240701\/1719799236887631.webp\" alt=\"3\" \/><\/section>\n<section>\u56fe2<\/p>\n<\/section>\n<section>\u9996\u5148\uff0c\u672c\u6587\u63a2\u7a76\u4e86HBO\u662f\u5426\u80fd\u591f\u6d88\u8017\u81f4\u5bc6\u7684ECM\u4ee5\u4fc3\u8fdb\u7ec6\u83cc(EcN)\u5728\u5b9e\u4f53\u7624\u5185\u7684\u79ef\u7d2f\u548c\u6e17\u900f\uff0c\u8fd9\u5bf9\u4e8e\u5b9e\u73b0\u6709\u6548\u7684\u57fa\u4e8e\u7ec6\u83cc\u7684\u764c\u75c7\u6cbb\u7597\u662f\u5fc5\u4e0d\u53ef\u5c11\u7684(\u56fe2a)\u3002\u4f5c\u8005\u4ece\u201c HBO +\u201d\u7ec4(\u5176\u4e2d\u8377\u7624\u5c0f\u9f20\u4ee51.5\u5927\u6c14\u7edd\u5bf9\u503c(ATA)\u7528 HBO 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(\u4f8b\u5982\u7ec6\u80de\u5916\u533a\u57df\uff0c\u7ec6\u80de\u5916\u6db2\uff0c\u7ec6\u80de\u5916\u95f4\u8d28\uff0c\u5916\u5305\u5c01\u7ed3\u6784\u548c\u542b\u80f6\u539f\u86cb\u767d\u7684\u7ec6\u80de\u5916\u95f4\u8d28)\u548c\u4e00\u4e9b\u751f\u7269\u8fc7\u7a0b(BP)\u76f8\u5173\u7684 DEGs (\u4f8b\u5982\u7ec6\u80de\u7c98\u9644\uff0c\u751f\u7269\u7c98\u9644\u548c\u7ec6\u80de-\u7ec6\u80de\u7c98\u9644)\u5728 HBO \u5904\u7406\u540e\u663e\u7740\u53d7\u5230\u5f71\u54cd\u3002\u6b64\u5916\uff0cKEGG \u5bcc\u96c6\u5206\u6790\u7ed3\u679c\u8868\u660e\uff0cDEG \u5728 ECM \u76f8\u5173\u9014\u5f84(\u4f8b\u5982 ECM \u53d7\u4f53\u76f8\u4e92\u4f5c\u7528)\u548c\u7ec6\u80de\u7c98\u9644\u76f8\u5173\u4fe1\u53f7\u4f20\u5bfc\u9014\u5f84(\u4f8b\u5982\u7c98\u7740\u6591)\u4e2d\u5bcc\u96c6(\u56fe2e)\u3002\u6b64\u5916\uff0cECM\u7684\u4e24\u4e2a\u4e3b\u8981\u7ec4\u5206(\u7ea4\u8fde\u86cb\u767d\u548c\u80f6\u539f)\u88ab\u67d3\u8272\uff0c\u5e76\u4e14\u5728 HBO 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ATA\uff0c2h)\u5904\u7406\u5c0f\u9f203\u6b21\uff0c\u5e76\u901a\u8fc7\u96c6\u843d\u8ba1\u6570\u91cf\u5316\u80bf\u7624\u4e2d\u7684\u7ec6\u83cc\u6570\u91cf\u3002\u5982\u56fe3d\u6240\u793a\uff0cHBO\u5904\u7406\u7ec424\/48\/72\u5c0f\u65f6\u7684 EcN \u96c6\u843d\u8ba1\u6570\u663e\u7740\u9ad8\u4e8e\u5bf9\u7167\u7ec4\uff0c\u8fd9\u4e0e\u7edf\u8ba1\u5b66\u7ed3\u679c\u4e00\u81f4(\u56fe3e)\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u201c HBO +\u201d\u7ec4\u7684 EcN \u6c34\u5e73\u572848\u5c0f\u65f6\u51e0\u4e4e\u8fbe\u5230\u5e73\u53f0(\u56fe3e)\uff0c\u8868\u660e\u53ea\u6709\u4e24\u6b21 HBO \u5904\u7406\u8db3\u4ee5\u5b9e\u73b0\u80bf\u7624\u5185\u663e\u7740\u589e\u52a0\u7684\u7ec6\u83cc\u79ef\u7d2f\u3002<\/p>\n<\/section>\n<section><img decoding=\"async\" title=\"5\" src=\"https:\/\/17332.seohost.cn\/storage\/17332\/article\/20240701\/1719799256872671.webp\" alt=\"5\" \/><\/section>\n<section>\u56fe4<\/p>\n<\/section>\n<section>\u672c\u6587\u8fdb\u4e00\u6b65\u63a2\u7a76\u4e86cypate\u4fee\u9970\u7684\u6700\u9002\u6d53\u5ea6\uff0c\u6839\u636e\u626b\u63cf\u7535\u5b50\u663e\u5fae\u955c(SEM)\u7684\u7ed3\u679c(\u56fe4a)\uff0cECN\u7684\u5f62\u6001\u4e0eECN-cypate\u7684\u5f62\u6001\u76f8\u4f3c\uff0c\u8868\u660ecypate\u4fee\u9970\u5bf9\u7ec6\u83cc\u7684\u5e72\u6270\u53ef\u4ee5\u5ffd\u7565\u4e0d\u8ba1\u3002\u968f\u540e\u8fdb\u884c\u4e86\u4e00\u7cfb\u5217\u7684\u5b9e\u9a8c\uff0c\u8bc1\u660e\u4e86cypate\u5728ECN\u8868\u9762\u7684\u5171\u8f6d\u662f\u6210\u529f\u7684\u3002\u5982\u56fe4b\u6240\u793a\uff0c\u80de\u679c\u9178\u7684\u7ea2\u8272\u8367\u5149\u663e\u793a\u5728\u7ec6\u83cc\u8868\u9762\u3002\u6b64\u5916\uff0cEcN-cypate\u7684\u8d1fzeta\u7535\u4f4d\u7684\u7edd\u5bf9\u503c\u76f8\u5bf9\u4e8eEcN(EcNcypate\u4e3a-48.5 \u00b1 4.7 mV\uff0cEcN \u4e3a -21.7 \u00b1 3.4 mV\uff0c\u56fe4c)\u589e\u52a0\uff0c\u56e0\u4e3a\u6bcf\u4e2a\u5171\u8f6d\u7684cypate\u5206\u5b50\u542b\u6709\u4e24\u4e2a\u7fa7\u57fa\u3002\u6b64\u5916\uff0cEcN-cypate (1185 \u00b1 188nm)\u76f8\u5bf9\u4e8e EcN (953 \u00b1 142nm)(\u56fe4d)\u5448\u73b0\u589e\u52a0\u7684\u6d41\u4f53\u52a8\u529b\u5b66\u76f4\u5f84\uff0c\u4ee5\u53ca\u4e0e\u6e38\u79bbcypate(\u56fe4e)\u76f8\u4f3c\u7684\u5438\u6536\u5cf0\uff0c\u8bc1\u660ecypate\u6210\u529f\u7684\u7f00\u5408\u5230\u7ec6\u83cc\u4e0a\u3002\u4e4b\u540e\uff0c\u4f5c\u8005\u8bc1\u660e\u4e86cypate\u4fee\u9970\u5bf9EcN\u662f\u5b89\u5168\u7684\uff0c\u56e0\u4e3aEcN\u548cECN-cypate\u7684\u751f\u957f\u66f2\u7ebf\u975e\u5e38\u76f8\u4f3c(\u56fe4f)\u3002\u603b\u7684\u6765\u8bf4\uff0c\u4fee\u9970\u7684EcN-cypate\u4fdd\u7559\u4e86\u5176\u539f\u6709\u7684\u5f62\u6001\u548c\u751f\u5b58\u80fd\u529b\u3002<\/p>\n<p>\u4e3a\u4e86\u6d4b\u8bd5cypate\u5bf9PTT\u7684\u6f5c\u5728\u4f5c\u7528\uff0c\u672c\u6587\u4f7f\u7528\u70ed\u6210\u50cf\u76f8\u673a\u6d4b\u91cf\u4e86\u542bECN-cypate\u7684\u60ac\u6d6e\u6db2\u7684\u5b9e\u65f6\u6e29\u5ea6\u53d8\u5316\u3002\u5982\u56fe4g\u6240\u793a\uff0c\u5f53\u7528NIR\u6fc0\u5149(808nm\uff0c1W\/cm2)\u8fde\u7eed\u7167\u5c04\u542b\u6709 EcN-cypate\u7684\u60ac\u6d6e\u6db27\u5206\u949f\u65f6\uff0c\u8bb0\u5f55\u5230\u660e\u663e\u7684\u6e29\u5ea6\u53d8\u5316\uff0c\u5bfc\u81f4EcN-cypate\u7684\u5f62\u6001\u6539\u53d8\u3002\u6b64\u5916\uff0cEcN-cypate \u8868\u73b0\u51fa\u591a\u91cd\u52a0\u70ed\u7535\u4f4d\uff0c\u8fd9\u53ef\u80fd\u4f7f\u8fdb\u4e00\u6b65\u91cd\u590dPTT(\u56fe4h)\u3002\u6839\u636eMTT\u6d4b\u5b9a\u7ed3\u679c\uff0cEcN-cypate \u5728\u6ca1\u6709\u6fc0\u5149\u7167\u5c04\u7684\u60c5\u51b5\u4e0b\u5448\u73b0\u826f\u597d\u7684\u7ec6\u80de\u76f8\u5bb9\u6027\uff0c\u5e76\u4e14\u57285 \u03bcg\/mL\u6d53\u5ea6\u4e0b\u5728\u6fc0\u5149\u7167\u5c04\u4e0b\u5177\u6709\u663e\u7740\u7684\u7ec6\u80de\u6bd2\u6027(\u56fe4i)\u3002\u4e3a\u4e86\u6e05\u695a\u5730\u663e\u793a EcN-cypate \u7684 PTT \u6548\u5e94\uff0c\u5c06\u4e0d\u540c\u5904\u7406\u540e\u76844T1\u7ec6\u80de\u4e0e\u9499\u9ec4\u7eff\u7d20\u4e59\u6c27\u57fa\u7532\u916f(calcein-AM)\u548c\u7898\u5316\u4e19\u5576(PI)\u5171\u67d3\u8272\uff0c\u5e76\u4e14\u6765\u81ea\u6b7b\u4ea1\u7ec6\u80de\u7684\u7ea2\u8272\u8367\u5149\u4fe1\u53f7\u8868\u660e EcN-cypate \u7684\u6709\u6548\u7684\u57fa\u4e8e PTT \u7684\u7ec6\u80de\u6740\u4f24\u80fd\u529b(\u56fe4j)\u3002<\/p>\n<\/section>\n<section><img decoding=\"async\" title=\"6\" src=\"https:\/\/17332.seohost.cn\/storage\/17332\/article\/20240701\/1719799266553509.webp\" alt=\"6\" \/><\/section>\n<section>\u56fe5<\/p>\n<\/section>\n<section>\u672c\u6587\u63a8\u6d4b\uff0cEcN-cypate\u4ecb\u5bfc\u7684 PTT \u53ef\u4ee5\u6740\u6b7b\u764c\u7ec6\u80de\u4ee5\u91ca\u653e DAMP\uff0c\u8fd9\u53cd\u8fc7\u6765\u53c8\u4fc3\u8fdbDC\u7684\u6210\u719f(\u56fe5a)\u3002\u4e3a\u4e86\u9a8c\u8bc1\u8fd9\u4e2a\u5047\u8bbe\uff0c\u672c\u6587\u5728\u4e0d\u540c\u7684\u5b9e\u9a8c\u7ec4\u4e2d\u68c0\u6d4b\u4e86\u4e09\u79cd\u4e3b\u8981DAMP\u7684\u91ca\u653e\uff0c\u5373\u4e09\u78f7\u9178\u817a\u82f7(ATP)\u3001\u9ad8\u8fc1\u79fb\u7387\u65cf\u86cb\u767d1(HMGB1)\u548c\u9499\u7f51\u86cb\u767d(CRT)\u3002\u5982\u56fe5b\uff0cc\u6240\u793a\uff0c\u4e0e\u5176\u4ed6\u7ec4\u76f8\u6bd4\uff0c\u7528EcN-cypate\u5b75\u80b2\u7684\u7ec6\u80de\u968f\u540e\u6fc0\u5149\u7167\u5c04(\u201c\u6fc0\u5149 +\u201d\u7ec4)\u8868\u73b0\u51fa\u7ec6\u80de\u5916ATP\u548cHMGB1\u6d53\u5ea6\u7684\u663e\u7740\u589e\u52a0\u3002\u6b64\u5916\uff0c\u8fd8\u6d4b\u91cf\u4e86CRT\u66b4\u9732\u6c34\u5e73\uff0c\u201c\u6fc0\u5149 +\u201d\u7ec4\u5448\u73b0\u6700\u9ad8\u6c34\u5e73\u7684CRT(\u56fe5d)\uff0c\u5728\u8d28\u819c\u8868\u9762\u68c0\u6d4b\u5230\u660e\u663e\u7684CRT\u4fe1\u53f7(\u56fe5e)\u3002\u5171\u805a\u7126\u6210\u50cf\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u201c\u6fc0\u5149-\u201d\u7ec4\u76f8\u6bd4\uff0c\u201c\u6fc0\u5149 +\u201d\u7ec4\u5728\u7ec6\u80de\u6838\u5185\u663e\u793a\u66f4\u5c11\u7684\u8367\u5149\u4fe1\u53f7(\u56fe5f)\u3002\u6d41\u5f0f\u7ed3\u679c\u663e\u793a\uff0c\u201c\u6fc0\u5149 +\u201d\u7ec4\u6210\u719fBMDC\u7684\u6bd4\u4f8b(74.0%)\u663e\u7740\u9ad8\u4e8e\u5bf9\u7167\u7ec4(28.4%)\u548c\u201c\u6fc0\u5149-\u201d(29.5%)\u7ec4(\u56fe5g)\u3002\u6b64\u5916\uff0c\u76f8\u5e94\u7684\u5b9a\u91cf\u5206\u6790\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u201c\u6fc0\u5149 +\u201d\u7ec4\u6210\u719f BMDC \u7684\u767e\u5206\u6bd4\u6700\u9ad8(\u56fe5h)\u3002<\/p>\n<\/section>\n<section><img decoding=\"async\" title=\"9\" src=\"https:\/\/17332.seohost.cn\/storage\/17332\/article\/20240701\/1719799280663200.webp\" alt=\"9\" \/><\/section>\n<section>\u56fe6<\/p>\n<\/section>\n<section>\u4e3a\u4e86\u7814\u7a76HBO\u662f\u5426\u5bf9\u5de5\u7a0b\u83cc(EcN-cypate)\u5177\u6709\u4e0e\u5929\u7136\u7ec6\u83cc(EcN)\u76f8\u5f53\u7684\u5f71\u54cd\uff0c\u672c\u6587\u68c0\u6d4b\u4e864T1\u8377\u7624\u5c0f\u9f20\u6a21\u578b\u4e2dEcN-cypate\u7684\u4f53\u5185\u5206\u5e03\u3002\u5982\u56fe6a\u6240\u793a\uff0cEcN-cypate\u5904\u7406\u7ec4\u6bd4\u6e38\u79bbcypate\u5904\u7406\u7ec4\u63d0\u4f9b\u66f4\u6709\u6548\u7684cypate\u7624\u5185\u9012\u9001\uff0c\u8fd9\u53ef\u80fd\u5f52\u56e0\u4e8eEcN\u7684\u7f3a\u6c27\u9776\u5411\u80fd\u529b\u3002\u6b64\u5916\uff0cHBO\u6cbb\u7597\u663e\u7740\u6539\u5584\u4e86EcN-cypate\u7684\u80bf\u7624\u5185\u9012\u9001\uff0c\u5728\u6ce8\u5c04\u540e48\u5c0f\u65f6\u89c2\u5bdf\u5230\u6700\u5927\u8367\u5149\u5f3a\u5ea6(\u56fe6a)\u3002\u4e3b\u8981\u5668\u5b98\u7684\u79bb\u4f53\u56fe\u50cf\u663e\u793a\u80f1\u6c28\u9178\u4e3b\u8981\u88ab\u809d\u810f\u6e05\u9664(\u56fe6a)\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u534a\u5b9a\u91cf\u5206\u6790cypate\u5206\u5e03\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86HBO\u5728\u4fc3\u8fdb\u57fa\u4e8e\u7ec6\u83cc\u7684\u836f\u7269\u7cfb\u7edf\u7684\u4f20\u9012\u4e2d\u7684\u5173\u952e\u4f5c\u7528(\u56fe6b)\u3002HBO\u6cbb\u7597\u540e\uff0c\u7f3a\u6c27\u8bf1\u5bfc\u56e0\u5b50-1\u03b1 (HIF-1\u03b1)\u7684\u8868\u8fbe\u4e0b\u964d(\u56fe6c)\uff0c\u8868\u660eHBO\u514b\u670d\u4e86\u80bf\u7624\u7f3a\u6c27\u3002\u63a5\u4e0b\u6765\uff0c\u672c\u6587\u8bc4\u4f30\u4e86ECN-cypate\u7684\u4f53\u5185PTT\u6548\u5e94\u3002\u5982\u56fe6d\u6240\u793a\uff0c\u5728\u8fd1\u7ea2\u5916\u6fc0\u5149\u7167\u5c04\u540e15\u5206\u949f\u5185\uff0cEcN-cypate\u548c\u201c EcN- \u534a\u80f1\u6c28\u9178 + HBO\u201d\u7ec4\u5747\u663e\u793a\u51fa\u663e\u7740\u7684\u80bf\u7624\u6e29\u5ea6\u5347\u9ad8\u3002\u5177\u4f53\u800c\u8a00\uff0c\u201c EcN-cypate + HBO\u201d\u7ec4\u7684\u6e29\u5ea6\u5728\u7167\u5c04\u671f\u95f4\u53ef\u4ee5\u589e\u52a0\u523048\u00b0C(\u56fe6e)\uff0c\u8fd9\u8db3\u4ee5\u5b9e\u73b0\u6709\u6548\u7684PTT\u3002<\/p>\n<\/section>\n<section><img decoding=\"async\" title=\"0\" src=\"https:\/\/17332.seohost.cn\/storage\/17332\/article\/20240701\/1719799294767492.webp\" alt=\"0\" \/><\/section>\n<section>\u56fe7<\/p>\n<\/section>\n<section>\u8fdb\u4e00\u6b65\uff0c\u672c\u6587\u7814\u7a76\u4e86\u8fd9\u79cdHBO\u8054\u5408PTT\u6cbb\u7597\u7684\u4f53\u5185\u6297\u80bf\u7624\u7684\u6027\u80fd\u3002\u5982\u56fe7a\u6240\u793a\uff0c\u4f5c\u8005\u4f9d\u6b21\u5c06HBO(1.5 ATA\uff0c2h)\u548c\u6fc0\u5149\u7167\u5c04(808nm\uff0c1W\/cm2,15\u5206\u949f)\u5e94\u7528\u4e8eEcN\u6ce8\u5c04\u7684\u5c0f\u9f20\uff0c\u5e76\u5728\u7b2c\u4e8c\u5929\u91cd\u590d\u4e0a\u8ff0\u8fc7\u7a0b\u4ee5\u589e\u5f3a\u6cbb\u7597\u6548\u679c\u3002\u5982\u56fe7b-g\u6240\u793a\uff0c\u201cEcN- cypate + HBO + \u6fc0\u5149\u201d\u7ec4\u5728\u6240\u6709\u7ec4\u4e2d\u8868\u73b0\u51fa\u6700\u4f73\u7684\u6cbb\u7597\u7ed3\u679c\uff0c\u9a8c\u8bc1\u4e86HBO\u548cEcN-cypate\u4ecb\u5bfc\u7684PTT\u7ec4\u5408\u7684\u9ad8\u6297\u80bf\u7624\u6548\u529b\u3002\u6b64\u5916\uff0c\u201cEcN-cypate + HBO\u201d\u7ec4\u663e\u793a\u51fa\u6bd4EcN-cypate\u7ec4\u66f4\u5f3a\u7684\u6297\u80bf\u7624\u4f5c\u7528(\u56fe7b\uff0cd\uff0ce)\u3002\u4e3a\u4e86\u89c2\u5bdf\u4e0d\u540c\u6cbb\u7597\u5bf9\u80bf\u7624\u533a\u57df\u7684\u635f\u4f24\uff0c\u672c\u6587\u5206\u522b\u7528\u82cf\u6728\u7cbe\u548c\u4f0a\u7ea2(H&amp;E)\u548c\u672b\u7aef\u8131\u6c27\u6838\u82f7\u9178\u8f6c\u79fb\u9176(tdT)\u4ecb\u5bfc\u7684dUTP\u7f3a\u53e3\u672b\u7aef\u6807\u8bb0(TUNEL)\u6d4b\u5b9a\u8bd5\u5242\u76d2\u5bf9\u80bf\u7624\u5207\u7247\u8fdb\u884c\u67d3\u8272\u3002\u6839\u636e\u5b9a\u91cfTUNEL\u6d4b\u5b9a\u8bd5\u5242\u76d2\u67d3\u8272\u7ed3\u679c\uff0c\u201cEcN- \u80f1\u6c28\u9178 + HBO + \u6fc0\u5149\u201d\u7ec4\u663e\u793a\u6700\u591a\u7684TUNEL\u8367\u5149\u4fe1\u53f7(\u56fe7h)\uff0c\u56fe7i\u8868\u660e\u8be5\u7ec4\u4e2d\u6700\u51cb\u4ea1\u7684\u7ec6\u80de\u3002\u7136\u540e\u4f5c\u8005\u8bc4\u4f30\u4e86cypate\u7684\u4f53\u5185\u751f\u7269\u5b89\u5168\u6027\uff0c\u6240\u6709\u7ec4\u4e4b\u95f4\u7684\u4f53\u91cd\u66f2\u7ebf\u8868\u73b0\u51fa\u53ef\u5ffd\u7565\u7684\u6ce2\u52a8(\u56fe7j)\u3002<\/p>\n<p>\u6700\u540e\u672c\u6587\u8fd8\u63a2\u7a76\u4e86HBO\u5076\u8054\u548cEcN-cypate\u4ecb\u5bfc\u7684PTT(HBO \u5076\u8054 PTT)\u91cd\u7f16\u7a0bTME\uff0cHBO\u589e\u5f3a\u7684\u5149\u70ed\u514d\u75ab\u6cbb\u7597\u7ed3\u5408PD1\u963b\u65ad\u6cbb\u7597\u6765\u9884\u9632\u80ba\u8f6c\u79fb\u3002<\/p>\n<\/section>\n<section>\u672c\u6587\u4f5c\u8005\uff1aMKQ<\/p>\n<p>\u8d23\u4efb\u7f16\u8f91\uff1aTZM<\/p>\n<p>DOI: 10.1038\/s41467-024-49156-6<\/p>\n<p>\u539f\u6587\u94fe\u63a5\uff1ahttps:\/\/doi.org\/10.1038\/s41467-024-49156-6<\/p>\n<\/section>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5206\u4eab\u4e00\u7bc7\u53d1\u8868\u5728Nature Communication\u4e0a\u7684\u6587\u7ae0\uff0c\u9898\u76ee\u4e3a\u201cHyperbaric oxygen e [&hellip;]<\/p>\n","protected":false},"author":326,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[],"class_list":["post-51842","post","type-post","status-publish","format-standard","hentry","category-tuijianyuedu"],"_links":{"self":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/51842","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/users\/326"}],"replies":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/comments?post=51842"}],"version-history":[{"count":1,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/51842\/revisions"}],"predecessor-version":[{"id":51843,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/51842\/revisions\/51843"}],"wp:attachment":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/media?parent=51842"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/categories?post=51842"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/tags?post=51842"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}