{"id":51830,"date":"2024-07-11T09:24:12","date_gmt":"2024-07-11T01:24:12","guid":{"rendered":"https:\/\/www.chemhui.com\/?p=51830"},"modified":"2024-07-02T09:24:29","modified_gmt":"2024-07-02T01:24:29","slug":"nat-chem-biol-%e8%89%b2%e6%b0%a8%e9%85%b8%e4%bb%a3%e8%b0%a2%e4%ba%a7%e7%89%a93-hk%e9%9d%b6%e5%90%91kainate%e5%8f%97%e4%bd%93%e6%9d%a5%e5%a2%9e%e5%bc%ba%e5%ae%bf%e4%b8%bb%e9%98%b2%e5%be%a1","status":"publish","type":"post","link":"http:\/\/www.chemhui.com\/nat-chem-biol-%e8%89%b2%e6%b0%a8%e9%85%b8%e4%bb%a3%e8%b0%a2%e4%ba%a7%e7%89%a93-hk%e9%9d%b6%e5%90%91kainate%e5%8f%97%e4%bd%93%e6%9d%a5%e5%a2%9e%e5%bc%ba%e5%ae%bf%e4%b8%bb%e9%98%b2%e5%be%a1\/","title":{"rendered":"Nat. Chem. Biol. | \u8272\u6c28\u9178\u4ee3\u8c22\u4ea7\u72693-HK\u9776\u5411Kainate\u53d7\u4f53\u6765\u589e\u5f3a\u5bbf\u4e3b\u9632\u5fa1\u80fd\u529b"},"content":{"rendered":"
\u5206\u4eab\u4e00\u7bc7\u53d1\u8868\u5728Nature Chemical Biology<\/span>\u4e0a\u7684\u6587\u7ae0\uff1a3-Hydroxykynurenine targets kainate receptors to promote defense against infection\uff0c\u901a\u8baf\u4f5c\u8005\u662f\u6765\u81ea\u9a6c\u8428\u8bf8\u585e\u5dde\u603b\u533b\u9662\u7684Deborah T. Hung\u6559\u6388\u548c\u4ed6\u4eec\u7ec4\u7684\u9ad8\u7ea7\u7814\u7a76\u79d1\u5b66\u5bb6Anne E. Clatworthy\uff0cHung\u8bfe\u9898\u7ec4\u7684\u7814\u7a76\u65b9\u5411\u662f\u7ed3\u5408\u5316\u5b66\u548c\u57fa\u56e0\u7ec4\u65b9\u6cd5\u7814\u7a76\u611f\u67d3\u6027\u75be\u75c5\u7684\u81f4\u75c5\u6027\u5e76\u5f00\u53d1\u65b0\u7684\u6cbb\u7597\u65b9\u6cd5\u3002<\/section>\n

 <\/p>\n

\"1\"<\/section>\n
\u7ec6\u83cc\u611f\u67d3\u6d89\u53ca\u75c5\u539f\u4f53\u548c\u5bbf\u4e3b\u4e4b\u95f4\u590d\u6742\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u89e3\u51b3\u7ec6\u83cc\u611f\u67d3\u7684\u4e3b\u8981\u6cbb\u7597\u7b56\u7565\u662f\u5728\u4f53\u5916\u9274\u5b9a\u6740\u6b7b\u6216\u9650\u5236\u7ec6\u83cc\u751f\u957f\u7684\u5206\u5b50\uff0c\u7136\u540e\u5c06\u8fd9\u4e9b\u6297\u751f\u7d20\u5e94\u7528\u5230\u4f53\u5185\u3002\u7136\u800c\uff0c\u8fd9\u79cd\u65b9\u6cd5\u5ffd\u7565\u4e86\u75c5\u539f\u4f53\u548c\u5bbf\u4e3b\u4e4b\u95f4\u590d\u6742\u7684\u52a8\u6001\u5173\u7cfb\uff0c\u4ee5\u53ca\u5b83\u4eec\u4e4b\u95f4\u76f8\u4e92\u4f5c\u7528\u6240\u6d89\u53ca\u7684\u673a\u5236\u3002\u4e3a\u4e86\u9610\u660e\u8fd9\u79cd\u76f8\u4e92\u4f5c\u7528\u4e2d\u6709\u52a9\u4e8e\u63a7\u5236\u611f\u67d3\u7684\u5173\u952e\u673a\u5236\uff0c\u672c\u6587\u4f5c\u8005\u8bd5\u56fe\u9274\u5b9a\u4e00\u4e9b\u901a\u8fc7\u6539\u53d8\u5bbf\u4e3b-\u75c5\u539f\u4f53\u52a8\u6001\u6765\u4f7f\u5bbf\u4e3b\u6062\u590d\u5065\u5eb7\u7684\u5c0f\u5206\u5b50\uff0c\u800c\u4e0d\u662f\u76f4\u63a5\u6740\u6b7b\u7ec6\u83cc\uff0c\u8fd9\u6837\u66f4\u52a0\u6709\u5229\u4e8e\u5bbf\u4e3b\u5065\u5eb7\u3002<\/strong><\/section>\n
\"2\"<\/section>\n
\u4e3a\u4e86\u786e\u5b9a\u4ee5\u8fd9\u79cd\u65b9\u5f0f\u8d77\u4f5c\u7528\u7684\u5206\u5b50\uff0c\u4f5c\u8005\u4f7f\u7528\u6591\u9a6c\u9c7c\u80da\u80ce\u4f5c\u4e3a\u810a\u690e\u52a8\u7269\u5bbf\u4e3b\u6a21\u578b\u8fdb\u884c\u4e86\u5168\u751f\u7269\u4f53\u5316\u5b66\u7b5b\u9009\uff0c\u56e0\u4e3a\u6591\u9a6c\u9c7c<\/span>\u7684\u514d\u75ab\u7cfb\u7edf\u4e0e\u54fa\u4e73\u52a8\u7269\u76f8\u4f3c\uff0c\u5e76\u4e14\u5b83\u4eec\u9002\u7528\u4e8e\u7ecf\u5178\u9057\u4f20\u5b66\u548c\u6297\u611f\u67d3\u5316\u5b66\u7b5b\u9009\u3002\u9996\u5148\u4f5c\u8005\u7b5b\u9009\u4e86932\u79cd\u5df2\u77e5\u751f\u7269\u6d3b\u6027\u5316\u5408\u7269\uff0c\u5e76\u53d1\u73b0\u5916\u6e90\u6027\u6dfb\u52a0\u8272\u6c28\u9178\u4ee3\u8c22\u72693-HK\u53ef\u4ee5\u9632\u6b62\u94dc\u7eff\u5047\u5355\u80de\u83cc<\/span>\u548c\u9f20\u4f24\u5bd2\u6c99\u95e8\u6c0f\u83cc\u7684\u7ec6\u83cc\u611f\u67d3\u3002\u7136\u800c\uff0c3-HK\u4e0d\u50cf\u4f20\u7edf\u6297\u751f\u7d20\u90a3\u6837\u8d77\u4f5c\u7528\uff0c\u5b83\u5bf9\u9f20\u4f24\u5bd2\u6c99\u95e8\u6c0f\u83cc\u6216\u94dc\u7eff\u5047\u5355\u80de\u83cc\u5728\u4f53\u5916\u751f\u957f\u6ca1\u6709\u5f71\u54cd\u3002\u9664\u4e86\u5916\u6e90\u6027\u8865\u51453-HK\u53ef\u4ee5\u9632\u6b62\u5168\u8eab\u7ec6\u83cc\u611f\u67d3\u5916\uff0c\u6291\u5236\u5176\u72ac\u5c3f\u6c28\u9178<\/span>\u9014\u5f84\u4ea7\u751f\u7684\u5185\u6e90\u60273-HK\u8fd8\u4f1a\u5bfc\u81f4\u5bbf\u4e3b\u5bf9\u611f\u67d3\u81f4\u654f\u3002<\/section>\n
\"6\"<\/section>\n
\u9274\u4e8e3-HK\u7684\u751f\u5b58\u76ca\u5904\u63ed\u793a\u4e86\u5bbf\u4e3b\u72ac\u5c3f\u6c28\u9178\u9014\u5f84\u5728\u514d\u75ab\u4e2d\u7684\u6f5c\u5728\u673a\u5236\uff0c\u662f\u4fc3\u8fdb\u5de8\u566c\u7ec6\u80de\u63a7\u5236\u7ec6\u83cc\u751f\u957f\u7684\u7279\u5f02\u6027\u4ee3\u8c22\u7269\uff0c\u4f5c\u8005\u8fdb\u4e00\u6b65\u57283-HK\u5b58\u5728\u548c\u7f3a\u5931\u7684\u60c5\u51b5\u4e0b\u5bf9\u611f\u67d3\u7684\u5de8\u566c\u7ec6\u80de\u8fdb\u884c\u4e86\u57fa\u56e0\u8868\u8fbe\u5206\u6790<\/span>\uff0c\u53d1\u73b0\u8272\u6c28\u9178\u4ee3\u8c22\u4ec5\u5728\u611f\u67d3\u7684\u5de8\u566c\u7ec6\u80de\u4e2d\u53d7\u5230\u6291\u5236\uff0c3-HK\u6c34\u5e73\u663e\u8457\u964d\u4f4e\u3002\u4f5c\u8005\u8fd8\u53d1\u73b03-HK\u5904\u7406\u540e\u7684\u5927\u591a\u6570\u8f6c\u5f55\u53d8\u5316\u53d1\u751f\u5728\u51e0\u79cd\u79bb\u5b50\u901a\u9053\u4e2d\uff0c\u5305\u62ec\u7535\u538b\u548c\u914d\u4f53\u95e8\u63a7\u79bb\u5b50\u901a\u9053\uff0c\u7279\u522b\u662fKainate\u53d7\u4f53(KAR)\u3002\u968f\u540e\u4f5c\u8005\u91c7\u7528\u4e86\u5316\u5b66\u9057\u4f20\u5b66\u65b9\u6cd5\uff0c\u6d4b\u8bd5KARs\u7684\u5df2\u77e5\u914d\u4f53\u662f\u5426\u53ef\u4ee5\u5728\u611f\u67d3\u4e2d\u91cd\u73b03-HK\u7684\u751f\u5b58\u76ca\u5904\uff0c\u5e76\u53d1\u73b0\u4e24\u79cd\u7ed3\u6784\u4e0d\u540c\u7684\u62ee\u6297\u5242CNQX\u548cNS 3763\u5747\u5177\u6709\u4fdd\u62a4\u5bbf\u4e3b\u611f\u67d3\u7684\u8868\u578b\uff0c\u800cKAR\u6fc0\u52a8\u5242kainate\u5177\u6709\u663e\u8457\u7684\u81f4\u654f\u4f5c\u7528\u3002<\/section>\n
\u7efc\u4e0a\uff0c\u672c\u7814\u7a76\u53d1\u73b0\u4ee3\u8c22\u72693-HK\u4ee5KAR\u4e3a\u9776\u70b9\uff0c\u901a\u8fc7\u4e00\u79cd\u65b0\u7684\u673a\u5236\u6539\u53d8\u4e86\u75c5\u539f\u4f53\u4e0e\u5bbf\u4e3b\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u9650\u5236\u7ec6\u83cc\u6269\u5f20\u4ece\u800c\u63d0\u9ad8\u5bbf\u4e3b\u7684\u751f\u5b58\u80fd\u529b\u3002<\/section>\n
\u672c\u6587\u4f5c\u8005\uff1aMB<\/section>\n
\u8d23\u4efb\u7f16\u8f91\uff1aZJ<\/section>\n
\u539f\u6587\u94fe\u63a5\uff1ahttps:\/\/www.nature.com\/articles\/s41589-024-01635-z<\/section>\n
\u6587\u7ae0\u5f15\u7528\uff1a10.1038\/s41589-024-01635-z<\/section>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u5206\u4eab\u4e00\u7bc7\u53d1\u8868\u5728Nature Chemical Biology\u4e0a\u7684\u6587\u7ae0\uff1a3-Hydroxykynurenine […]<\/p>\n","protected":false},"author":326,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[],"class_list":["post-51830","post","type-post","status-publish","format-standard","hentry","category-tuijianyuedu"],"_links":{"self":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/51830","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/users\/326"}],"replies":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/comments?post=51830"}],"version-history":[{"count":1,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/51830\/revisions"}],"predecessor-version":[{"id":51831,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/51830\/revisions\/51831"}],"wp:attachment":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/media?parent=51830"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/categories?post=51830"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/tags?post=51830"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}