{"id":51432,"date":"2024-05-14T08:44:43","date_gmt":"2024-05-14T00:44:43","guid":{"rendered":"https:\/\/www.chemhui.com\/?p=51432"},"modified":"2024-05-05T21:48:09","modified_gmt":"2024-05-05T13:48:09","slug":"nat-biotechnol-%e7%a5%9e%e7%bb%8f%e7%bd%91%e7%bb%9c%e7%94%9f%e6%88%90%e9%85%b6%e7%9a%84%e8%ae%a1%e7%ae%97%e8%af%84%e5%88%86%e5%92%8c%e5%ae%9e%e9%aa%8c%e8%af%84%e4%bc%b0","status":"publish","type":"post","link":"http:\/\/www.chemhui.com\/nat-biotechnol-%e7%a5%9e%e7%bb%8f%e7%bd%91%e7%bb%9c%e7%94%9f%e6%88%90%e9%85%b6%e7%9a%84%e8%ae%a1%e7%ae%97%e8%af%84%e5%88%86%e5%92%8c%e5%ae%9e%e9%aa%8c%e8%af%84%e4%bc%b0\/","title":{"rendered":"Nat. Biotechnol. | \u795e\u7ecf\u7f51\u7edc\u751f\u6210\u9176\u7684\u8ba1\u7b97\u8bc4\u5206\u548c\u5b9e\u9a8c\u8bc4\u4f30"},"content":{"rendered":"<p>\u5206\u4eab\u4e00\u7bc7\u53d1\u8868\u5728Nature Biotechnology\u4e0a\u7684\u6587\u7ae0\uff0c\u6587\u7ae0\u6807\u9898\u201cComputational scoring and experimental evaluation of enzymes generated by neural networks\u201d\uff0c\u6587\u7ae0\u7684\u901a\u8baf\u4f5c\u8005\u662f\u6765\u81ea\u5fae\u8f6f\u7814\u7a76\u9662\u7684Kevin K. Yang\u548c\u67e5\u5c14\u59c6\u65af\u7406\u5de5\u5927\u5b66\u7684Aleksej Zelezniak\u3002\u5176\u4e2dKevin K. Yang\u4e3b\u8981\u4ece\u4e8b\u673a\u5668\u5b66\u4e60\u86cb\u767d\u8d28\u5de5\u7a0b\u65b9\u9762\u7684\u7814\u7a76\uff0cAleksej Zelezniak\u4e3b\u8981\u7814\u7a76\u5174\u8da3\u662f\u57fa\u4e8e\u8ba1\u7b97\u9884\u6d4b\u7684\u7cfb\u7edf\u751f\u7269\u5b66\u7814\u7a76\u3002<\/p>\n<section><img decoding=\"async\" title=\"1\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20240505\/1714916816876392.png\" alt=\"1\" \/><\/section>\n<section><\/section>\n<section>\u86cb\u767d\u8d28\u5e8f\u5217\u751f\u6210\u6a21\u578b\u662f\u4e00\u79cd\u901a\u8fc7\u62df\u5408\u81ea\u7136\u754c\u4e2d\u86cb\u767d\u8d28\u5e8f\u5217\u5206\u5e03\u3001\u4e0d\u65ad\u91c7\u6837\u83b7\u5f97\u65b0\u5e8f\u5217\u7684\u751f\u6210\u6a21\u578b\u3002\u7136\u800c\uff0c\u9884\u6d4b\u751f\u6210\u7684\u86cb\u767d\u8d28\u80fd\u5426\u6298\u53e0\u5e76\u53d1\u6325\u76f8\u5e94\u529f\u80fd\u4ecd\u5177\u6709\u6311\u6218\u6027\u3002\u5176\u4e2d\u4e3b\u8981\u56f0\u96be\u5728\u4e8e\uff0c\u86cb\u767d\u8d28\u5e8f\u5217\u751f\u6210\u6a21\u578b\u901a\u5e38\u4ee5\u751f\u6210\u5e8f\u5217\u548c\u81ea\u7136\u754c\u5df2\u6709\u5e8f\u5217\u7684\u6bd4\u5bf9\u5206\u6570\uff08\u76f8\u4f3c\u6027\uff09\u4f5c\u4e3a\u8bc4\u4f30\u6307\u6807\u3002\u800c\u8fd9\u79cd\u57fa\u4e8e\u5e8f\u5217\u540c\u4e00\u6027\u3001\u5bf9\u6bcf\u4e2a\u4f4d\u7f6e\u8d4b\u4e88\u76f8\u540c\u6743\u91cd\u7684\u6307\u6807\u6709\u5229\u4e8e\u6355\u83b7\u5168\u5c40\u7684\u3001\u4e00\u822c\u7684\u5e8f\u5217\u7279\u6027\uff0c\u4f46\u662f\u5374\u4e0d\u5229\u4e8e\u6355\u83b7\u67d0\u4e9b\u7279\u5b9a\u4f4d\u7f6e\u7684\u4e0a\u4f4d\u6548\u5e94\u3002\u8fd9\u5bfc\u81f4\u6a21\u578b\u5bf9\u4e8e\u81f4\u75c5\u6027\u9519\u4e49\u7a81\u53d8\uff08\u8868\u8fbe\u6c34\u5e73\u6216\u8005\u6d3b\u6027\u4e0d\u826f\uff09\u4e0d\u591f\u654f\u611f\u3002\u56e0\u6b64\uff0c\u4e00\u79cd\u53ef\u884c\u7684\u601d\u8def\u662f\u8054\u5408\u5176\u5b83\u7c7b\u578b\u7684\u6307\u6807\u9884\u6d4b\u751f\u6210\u5e8f\u5217\u7684\u6d3b\u6027\u3002\u6bd4\u5982\uff0c\u5c06\u86cb\u767d\u8d28\u8bed\u8a00\u6a21\u578b\u7684\u8bc4\u4f30\u7ed3\u679c\u8003\u8651\u5728\u5185\uff0c\u53ef\u80fd\u589e\u5f3a\u6a21\u578b\u5bf9\u4e8e\u5e8f\u5217\u4e2d\u67d0\u4e9b\u7f3a\u9677\u7684\u8bc6\u522b\u80fd\u529b\uff1b\u5f15\u5165Rosetta\u6253\u5206\u6216\u8005AlphaFold2\u7684\u6b8b\u57fa\u7f6e\u4fe1\u5ea6\u6253\u5206\uff0c\u5219\u6709\u671b\u589e\u5f3a\u6a21\u578b\u5bf9\u4e8e\u86cb\u767d\u8d28\u80fd\u5426\u6298\u53e0\u81f3\u7a33\u5b9a\u7ed3\u6784\u7684\u5224\u65ad\u80fd\u529b\u3002\u57fa\u4e8e\u6b64\uff0c<strong>\u672c\u6587\u4f5c\u8005\u5f00\u53d1\u5e76\u5b9e\u9a8c\u9a8c\u8bc1\u4e86\u86cb\u767d\u8d28\u5e8f\u5217\u9009\u62e9\u7684\u590d\u5408\u6307\u6807\uff08composite metrics for protein sequence selection\uff0c\u00a0COMPSS\uff09\uff0c\u7528\u4e8e\u6311\u9009\u5177\u6709\u9176\u6d3b\u6027\u7684\u86cb\u767d\u8d28\u5e8f\u5217\u3002<\/strong><\/section>\n<section>COMPSS\u5305\u542b\u5982\u4e0b\u4e09\u7c7b\u6307\u6807\uff1a\u57fa\u4e8e\u5355\u5e8f\u5217\u7684\u6307\u6807\u3001\u57fa\u4e8e\u591a\u5e8f\u5217\u6bd4\u5bf9\u7684\u6307\u6807\u3001\u57fa\u4e8e\u7ed3\u6784\u7684\u6307\u6807\u3002\u4f5c\u8005\u8bbe\u8ba1\u7684\u5b9e\u9a8c\u6846\u67b6\u5982\u4e0b\uff1a\u9488\u5bf9\u67d0\u4e00\u86cb\u767d\u8d28\u529f\u80fd\uff0c\u9996\u5148\u4f7f\u7528\u7b80\u5355\u7684\u8bc4\u4f30\u6307\u6807\uff08\u6bd4\u5982\u57fa\u4e8e\u5355\u5e8f\u5217\u7684\u76f8\u4f3c\u6027\uff09\u8fc7\u6ee4\u5e8f\u5217\u5e76\u52a0\u4ee5\u5b9e\u9a8c\u9a8c\u8bc1\uff1b\u6839\u636e\u5b9e\u9a8c\u9a8c\u8bc1\u7ed9\u51fa\u7684\u7ed3\u679c\u8fdb\u4e00\u6b65\u8bad\u7ec3\u6a21\u578b\u3001\u4f18\u5316COMPSS\uff1b\u6700\u540e\u5b9e\u9a8c\u9a8c\u8bc1COMPSS\u7684\u8868\u73b0\u3002<\/section>\n<section><img decoding=\"async\" title=\"2\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20240505\/1714916824145151.png\" alt=\"2\" \/><\/section>\n<section><\/section>\n<section>\u5728\u672c\u6587\u4e2d\uff0c\u4f5c\u8005\u9488\u5bf9\u82f9\u679c\u9178\u8131\u6c22\u9176\uff08MDH\uff09\u548c\u94dc\u8d85\u6c27\u5316\u7269\u6b67\u5316\u9176\uff08CuSOD\uff09\u6765\u4f18\u5316COMPSS\u7684\u6307\u6807\u3002\u5728\u7b2c\u4e00\u8f6e\u7b80\u5355\u8fc7\u6ee4\u7684\u5b9e\u9a8c\u4e2d\uff0c\u4f5c\u8005\u4ece\u8d85\u8fc730000\u6761\u751f\u6210\u5e8f\u5217\u4e2d\u6311\u9009\u4e86144\u6761\u5e8f\u5217\u7528\u4e8e\u5b9e\u9a8c\u9a8c\u8bc1\u3002\u8fd9\u4e9b\u5e8f\u5217\u4e0e\u5929\u7136\u5e8f\u5217\u7684\u76f8\u4f3c\u5ea6\u572870%\u523080%\u4e4b\u95f4\u3002\u7ed3\u679c\u8868\u660e\uff0c\u5927\u7ea619%\u5177\u6709\u6d3b\u6027\u3002\u5728\u7b2c\u4e8c\u8f6e\u8bad\u7ec3\u4e2d\uff0c\u4f5c\u8005\u5f15\u5165\u4e86\u65b0\u7684\u6307\u6807\uff08ESM-1v\u548cProteinMPNN\u7b49\u7b49\uff09\u5e76\u5728\u989d\u5916\u52a0\u5165\u6821\u51c6\u540e\u7684\u6570\u636e\u91cd\u65b0\u8bad\u7ec3\u4e86\u5e8f\u5217\u751f\u6210\u6a21\u578b\u3002\u5176\u4e2d\uff0c60%\u4ee5\u4e0a\u7684\u86cb\u767d\u8d28\u5448\u73b0\u51fa\u9176\u6d3b\u6027\u3002\u5728\u7b2c\u4e09\u8f6e\u7684\u9a8c\u8bc1\u73af\u8282\uff0cCOMPSS\u8868\u73b0\u51fa\u5bf9\u6d3b\u6027\u86cb\u767d\u8d28\u7684\u5bcc\u96c6\u80fd\u529b\u3002<\/section>\n<section><img decoding=\"async\" title=\"3\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20240505\/1714916835516579.png\" alt=\"3\" \/>\u200b<\/section>\n<section><\/section>\n<section>\u4f5c\u8005\u6700\u540e\u6307\u51fa\uff0cCOMPSS\u00a0\u7684\u6838\u5fc3\u601d\u60f3\u662f\u901a\u8fc7\u751f\u7269\u5b66\u9a71\u52a8\u7684\u8d28\u91cf\u68c0\u67e5\u548c\u86cb\u767d\u8d28\u8bed\u8a00\u6a21\u578b\u8bc4\u5206\u8fdb\u884c\u9884\u8fc7\u6ee4\u6765\u9009\u62e9\u5e8f\u5217\uff0c\u6700\u540e\u5229\u7528\u76f8\u5bf9\u8017\u65f6\u7684\u7ed3\u6784\u9884\u6d4b\u8fdb\u884c\u6700\u7ec8\u8bc4\u5206\u3002\u4f5c\u8005\u4e0d\u5efa\u8bae\u5728\u4e0d\u8003\u8651\u751f\u7269\u5b66\u590d\u6742\u6027\u7684\u60c5\u51b5\u4e0b\u76f2\u76ee\u5730\u5c06COMPSS\u5e94\u7528\u4e8e\u65b0\u7684\u86cb\u767d\u8d28\u5bb6\u65cf\u3002<\/section>\n<section><\/section>\n<section><\/section>\n<section>\u672c\u6587\u4f5c\u8005\uff1aZF<\/section>\n<section>\u8d23\u4efb\u7f16\u8f91\uff1aFTY<\/section>\n<section>\u6587\u7ae0\u94fe\u63a5\uff1ahttps:\/\/www.nature.com\/articles\/s41587-024-02214-2<\/section>\n<section><\/section>\n<section>\u539f\u6587\u5f15\u7528\uff1aDOI:\u00a010.1038\/s41587-024-02214-2<\/section>\n","protected":false},"excerpt":{"rendered":"<p>\u5206\u4eab\u4e00\u7bc7\u53d1\u8868\u5728Nature Biotechnology\u4e0a\u7684\u6587\u7ae0\uff0c\u6587\u7ae0\u6807\u9898\u201cComputational scor [&hellip;]<\/p>\n","protected":false},"author":326,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[],"class_list":["post-51432","post","type-post","status-publish","format-standard","hentry","category-tuijianyuedu"],"_links":{"self":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/51432","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/users\/326"}],"replies":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/comments?post=51432"}],"version-history":[{"count":1,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/51432\/revisions"}],"predecessor-version":[{"id":51433,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/51432\/revisions\/51433"}],"wp:attachment":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/media?parent=51432"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/categories?post=51432"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/tags?post=51432"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}