{"id":51349,"date":"2024-05-01T08:44:20","date_gmt":"2024-05-01T00:44:20","guid":{"rendered":"https:\/\/www.chemhui.com\/?p=51349"},"modified":"2024-04-22T10:49:23","modified_gmt":"2024-04-22T02:49:23","slug":"angew-chem-%ef%bc%9a%e6%9e%84%e5%bb%ba%e6%96%b0%e5%9e%8b%e6%8a%97%e4%bd%93-%e5%a4%9a%e8%82%bd%e5%81%b6%e8%81%94%e7%89%a9%e9%80%9a%e8%bf%87%e5%88%86%e5%ad%90%e4%bc%b4%e4%be%a3%e4%bb%8b%e5%af%bc","status":"publish","type":"post","link":"http:\/\/www.chemhui.com\/angew-chem-%ef%bc%9a%e6%9e%84%e5%bb%ba%e6%96%b0%e5%9e%8b%e6%8a%97%e4%bd%93-%e5%a4%9a%e8%82%bd%e5%81%b6%e8%81%94%e7%89%a9%e9%80%9a%e8%bf%87%e5%88%86%e5%ad%90%e4%bc%b4%e4%be%a3%e4%bb%8b%e5%af%bc\/","title":{"rendered":"Angew. 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\/><\/section>\n<section>\n<section>\n<section>\n<section>\n<section>CMA\u662f\u4e00\u79cd\u72ec\u7279\u7684\u6eb6\u9176\u4f53\u86cb\u767d\u6c34\u89e3\u9014\u5f84\uff0c\u7531\u80de\u8d28\u5185\u5206\u5b50\u4f34\u4fa3Hsc70\u4ecb\u5bfc\u5e95\u7269\u86cb\u767d\u7ecf\u6eb6\u9176\u4f53\u819c\u86cb\u767dLAMP2A\u8fdb\u5165\u6eb6\u9176\u4f53\u800c\u88ab\u9009\u62e9\u6027\u964d\u89e3\u3002Ab-CMA\u7b56\u7565\u5c06\u9776\u5411CMA\u7684\u591a\u80bd\uff08KFERQKILDQRFFE\uff09\u5171\u4ef7\u5076\u8054\u81f3\u5546\u4e1a\u5316\u5355\u514b\u9686\u6297\u4f53\uff08\u4ee5\u9776\u5411EGFR\u3001PD-L1\u6216HER2\u7684\u5355\u6297\u4e3a\u4f8b\uff09\uff0c\u5728\u4e0d\u540c\u7ec6\u80de\u7cfb\u4e2d\u5b9e\u73b0\u4e86\u6d53\u5ea6\u3001\u65f6\u95f4\u4f9d\u8d56\u578b\u7684\u9776\u6807\u964d\u89e3\u3002\u673a\u5236\u7814\u7a76\u5b9e\u9a8c\u8868\u660e\uff0cAb-CMA\u8bf1\u5bfc\u7684\u819c\u86cb\u767d\u964d\u89e3\u4f9d\u8d56\u6eb6\u9176\u4f53\uff0c\u5e76\u4e14\u9700\u8981CMA\u901a\u8def\u7684\u5173\u952e\u6807\u5fd7\u7269\u2014\u2014LAMP2A\u548cHsc70\u7684\u53c2\u4e0e\uff0c\u8868\u660eAb-CMA\u901a\u8fc7\u5206\u5b50\u4f34\u4fa3\u4ecb\u5bfc\u7684\u81ea\u566c\u8bf1\u5bfc\u7ec6\u80de\u8868\u9762\u819c\u86cb\u767d\u201c\u7531\u5916\u5230\u5185\u201d\u7684\u9776\u5411\u964d\u89e3\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section><\/section>\n<\/section>\n<section><img decoding=\"async\" title=\"2\" src=\"https:\/\/17332.seohost.cn\/storage\/17332\/article\/20240422\/1713753927131377.webp\" alt=\"2\" \/><\/section>\n<section>\n<section>\n<section>\n<section>\n<section>\u5728\u7ec6\u80de\u5c42\u9762\u9a8c\u8bc1Ab-CMA\u7684\u964d\u89e3\u529f\u80fd\u540e\uff0c\u4f5c\u8005\u4ee5\u9776\u5411EGFR\u7684<span class=\"wx_search_keyword_wrap\">\u897f\u59a5\u6614\u5355\u6297<\/span>\uff08Ctx\uff09\u4e3a\u4f8b\uff0c\u8bc4\u4f30\u4e86\u5076\u8054\u591a\u80bd\u7684Ctx-CMA\u5728\u8377\u7624\u5c0f\u9f20\u6a21\u578b\u4e2d\u7684\u80bf\u7624\u6291\u5236\u80fd\u529b\uff0c\u7ed3\u679c\u8868\u660e\uff0c\u8be5<span class=\"wx_search_keyword_wrap\">\u6297\u4f53\u5076\u8054\u7269<\/span>\u7684\u6291\u7624\u6548\u679c\u663e\u8457\u4f18\u4e8e\u672a\u4fee\u9970\u7684\u6297\u4f53\uff0c\u5e76\u4e14\u80bf\u7624\u7ec4\u7ec7\u4e2d\u7684EGFR\u86cb\u767d\u6c34\u5e73\u4e5f\u663e\u8457\u964d\u4f4e\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section><\/section>\n<\/section>\n<section><img decoding=\"async\" title=\"8\" src=\"https:\/\/17332.seohost.cn\/storage\/17332\/article\/20240422\/1713753946259843.webp\" alt=\"8\" \/>\u200b<\/section>\n<section>\n<section>\n<section>\n<section>\n<section>\u7efc\u4e0a\uff0cAb-CMA\u6280\u672f\u5177\u6709\u666e\u9002\u6027\u548c\u6a21\u5757\u5316\u7b49\u4f18\u70b9\uff0c\u53d1\u5c55\u4e86\u57fa\u4e8e\u201c\u5206\u5b50\u4f34\u4fa3\u4ecb\u5bfc\u7684\u81ea\u566c\u201d\u7684\u819c\u86cb\u767d\u9776\u5411\u964d\u89e3\u65b0\u6a21\u5f0f\uff0c\u4e3a\u819c\u86cb\u767d\u7684\u529f\u80fd\u7814\u7a76\u53ca\u76f8\u5173\u75be\u75c5\u6cbb\u7597\u63d0\u4f9b\u4e86\u65b0\u601d\u8def\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section><\/section>\n<\/section>\n<section>\n<section>\n<section>\n<section><strong>\u8bba<\/strong><strong>\u6587\u4fe1\u606f<\/strong><\/p>\n<\/section>\n<\/section>\n<section>\n<section><\/section>\n<\/section>\n<section>\n<section>\n<section>\n<section>\n<section><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>Targeted Degradation of Cell-Surface Proteins via Chaperone-Mediated Autophagy by Using Peptide-Conjugated Antibodies<\/p>\n<p>Jinning Shao,\u00a0Xuefen Lin,\u00a0Haoting Wang,\u00a0Chuhan Zhao,\u00a0Prof.\u2005Dr. Shao Q. Yao,\u00a0Prof.\u2005Dr. Jingyan Ge,\u00a0Prof.\u2005Dr. Su Zeng,\u00a0Prof.\u2005Dr. Linghui Qian<\/p>\n<p>\u6587\u7ae0\u7684\u7b2c\u4e00\u4f5c\u8005\u662f\u6d59\u6c5f\u5927\u5b66\u836f\u5b66\u9662\u7684\u535a\u58eb\u751f\u90b5\u747e\u5b81\uff0c\u901a\u8baf\u4f5c\u8005\u4e3a\u6d59\u6c5f\u5927\u5b66\u201c\u767e\u4eba\u8ba1\u5212\u201d\u7814\u7a76\u5458\u94b1\u73b2\u6167\uff0c\u8bfe\u9898\u7ec4\u81f4\u529b\u4e8e\u819c\u86cb\u767d\u7684\u539f\u4f4d\u53ef\u89c6\u5316\u68c0\u6d4b\u4e0e\u9776\u5411\u8c03\u63a7\u7814\u7a76\u3002\u611f\u8c22\u6d59\u6c5f\u5927\u5b66\u836f\u5b66\u9662\u66fe\u82cf\u6559\u6388\u3001\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u59da\u5c11\u94a6\u6559\u6388\u548c\u6d59\u6c5f\u5de5\u4e1a\u5927\u5b66\u845b\u749f\u71d5\u6559\u6388\u5bf9\u8be5\u9879\u76ee\u7684\u6307\u5bfc\u4e0e\u652f\u6301\uff0c\u611f\u8c22\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u7b49\u9879\u76ee\u7684\u8d44\u91d1\u8d44\u52a9\u3002<\/p>\n<p><em>Angewandte Chemie International Edition<\/em><\/p>\n<p>DOI:\u00a010.1002\/anie.202319232<\/p>\n<\/section>\n<\/section>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>\u4f4d\u4e8e\u7ec6\u80de\u8868\u9762\u7684\u819c\u86cb\u767d\u5728\u4fe1\u53f7\u8f6c\u5bfc\u3001\u7269\u8d28\u8fd0\u8f93\u3001\u7ec6\u80de\u95f4\u4ea4\u4e92\u4f5c\u7528\u7b49\u591a\u79cd\u751f\u7269\u8fc7\u7a0b\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\uff0c\u5176\u529f\u80fd\u969c\u788d\u4e0e\u8bb8\u591a\u75be\u75c5\u5bc6\u5207 [&hellip;]<\/p>\n","protected":false},"author":326,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[],"class_list":["post-51349","post","type-post","status-publish","format-standard","hentry","category-tuijianyuedu"],"_links":{"self":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/51349","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/users\/326"}],"replies":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/comments?post=51349"}],"version-history":[{"count":1,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/51349\/revisions"}],"predecessor-version":[{"id":51350,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/51349\/revisions\/51350"}],"wp:attachment":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/media?parent=51349"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/categories?post=51349"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/tags?post=51349"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}