{"id":51266,"date":"2024-04-18T08:44:24","date_gmt":"2024-04-18T00:44:24","guid":{"rendered":"https:\/\/www.chemhui.com\/?p=51266"},"modified":"2024-04-09T10:46:36","modified_gmt":"2024-04-09T02:46:36","slug":"j-am-chem-soc-%e8%9e%ba%e7%8e%af%e4%b8%99%e7%83%af%e9%85%b0%e8%83%ba%e7%ab%8b%e4%bd%93%e6%8e%a2%e9%92%88%e7%9a%84%e8%9b%8b%e7%99%bd%e8%b4%a8%e7%bb%84%e5%ad%a6%e9%85%8d%e4%bd%93%e6%80%a7%e5%9b%be","status":"publish","type":"post","link":"http:\/\/www.chemhui.com\/j-am-chem-soc-%e8%9e%ba%e7%8e%af%e4%b8%99%e7%83%af%e9%85%b0%e8%83%ba%e7%ab%8b%e4%bd%93%e6%8e%a2%e9%92%88%e7%9a%84%e8%9b%8b%e7%99%bd%e8%b4%a8%e7%bb%84%e5%ad%a6%e9%85%8d%e4%bd%93%e6%80%a7%e5%9b%be\/","title":{"rendered":"J. Am. Chem. Soc. | \u87ba\u73af\u4e19\u70ef\u9170\u80fa\u7acb\u4f53\u63a2\u9488\u7684\u86cb\u767d\u8d28\u7ec4\u5b66\u914d\u4f53\u6027\u56fe\u8c31\u9274\u5b9a\u5171\u4ef7 ERCC3 \u964d\u89e3\u5242"},"content":{"rendered":"<p>\u5206\u4eab\u4e00\u7bc7\u53d1\u8868\u5728JACS\u4e0a\u7684\u6587\u7ae0\uff1aProteomic Ligandability Maps of Spirocycle Acrylamide Stereoprobes Identify Covalent ERCC3 Degraders\uff0c\u901a\u8baf\u4f5c\u8005\u662fScripps\u7814\u7a76\u6240\u7684Benjamin Cravatt\u548cBruno Melillo\u4e24\u4f4d\u6559\u6388\u3002<strong>\u5728\u8fd9\u7bc7\u6587\u7ae0\u4e2d\uff0c\u4f5c\u8005\u901a\u8fc7ABPP\u6280\u672f\u53d1\u73b0\u4e86ERCC3\u86cb\u767d\u7684\u4e00\u79cd\u5171\u4ef7\u964d\u89e3\u5242\u3002<\/strong><\/p>\n<section><img decoding=\"async\" title=\"1\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20240409\/1712630726721822.png\" alt=\"1\" \/><\/section>\n<section>ABPP\u6280\u672f\u53ef\u4ee5\u901a\u8fc7\u4e0e\u9776\u5411\u4eb2\u6838\u6c28\u57fa\u9178\u7684\u53cd\u5e94\u6027\u5c0f\u5206\u5b50\u63a2\u9488\u7ade\u4e89\u6765\u8bc4\u4f30\u4eb2\u7535\u5316\u5408\u7269\u4e0e\u86cb\u767d\u8d28\u7ec4\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u5728\u8fd9\u4e9b\u4eb2\u7535\u5316\u5408\u7269\u4e2d\uff0c\u4eb2\u7535\u7acb\u4f53\u63a2\u9488\u5177\u6709\u4f4d\u70b9\u7279\u5f02\u6027\u3001\u7acb\u4f53\u9009\u62e9\u6027\u548c\u7528\u4e8e\u7ec6\u80de\u751f\u7269\u5b66\u7814\u7a76\u7684\u8db3\u591f\u6548\u529b\u3002\u56e0\u6b64\uff0c\u4f5c\u8005\u5728\u8fd9\u7bc7\u6587\u7ae0\u4e2d\u5bf9\u4e00\u7ec4\u87ba\u73af\u4e19\u70ef\u9170\u80fa\u7acb\u4f53\u63a2\u9488\u8fdb\u884c\u4e86\u5316\u5b66\u86cb\u767d\u8d28\u7ec4\u5b66\u5206\u6790\u3002<\/section>\n<section><img decoding=\"async\" title=\"2\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20240409\/1712630734882354.png\" alt=\"2\" \/><\/section>\n<section>\u4f5c\u8005\u9996\u5148\u5408\u6210\u4e86\u4e00\u7ec4\u5305\u542b16\u4e2a\u533a\u57df\u5f02\u6784\u4f53\u548c\u7acb\u4f53\u5f02\u6784\u4f53\u7684\u87ba\u73af\u4e19\u70ef\u9170\u80fa\u5e93\uff0c\u5e76\u5229\u7528\u5176\u4e2d\u5e26\u6709\u7094\u57fa\u76844\u4e2a\u63a2\u9488\u8fdb\u884c\u4e86\u51dd\u80f6-ABPP\u5b9e\u9a8c\u3002\u4e0e\u4f5c\u8005\u6b64\u524d\u5f00\u53d1\u7684\u6c2e\u6742\u73af\u4e01\u70f7\u4e19\u70ef\u9170\u80fa\u76f8\u6bd4\uff0c\u87ba\u73af\u4e19\u70ef\u9170\u80fa\u8868\u73b0\u51fa\u66f4\u4f4e\u7684\u86cb\u767d\u8d28\u7ec4\u53cd\u5e94\u6027\uff0c\u4f46\u53ef\u4ee5\u89c2\u5bdf\u5230\u5176\u4e0e\u86cb\u767d\u8d28\u7ec4\u7684\u76f8\u4e92\u4f5c\u7528\u5177\u6709\u7acb\u4f53\u9009\u62e9\u6027\u3002<\/section>\n<section><img decoding=\"async\" title=\"3\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20240409\/1712630744233426.png\" alt=\"3\" \/><\/section>\n<section>\u968f\u540e\uff0c\u4f5c\u8005\u5bf9\u87ba\u73af\u4e19\u70ef\u9170\u80fa\u63a2\u9488\u8fdb\u884c\u4e86\u7ade\u4e89\u6027ABPP\u5b9e\u9a8c\uff0c\u5229\u7528\u7898\u4e59\u9170\u80fa\u8131\u786b\u751f\u7269\u7d20\u63a2\u9488\u8fdb\u884c\u6807\u8bb0\u5e76\u5229\u7528TMT\u8fdb\u884c\u8d28\u8c31\u5b9a\u91cf\u3002\u5728\u7ed3\u679c\u4e2d\uff0c\u670914\u4e2a\u534a\u80f1\u6c28\u9178\u6b8b\u57fa\u88ab\u87ba\u73af\u4e19\u70ef\u9170\u80fa\u7acb\u4f53\u9009\u62e9\u6027\u5730\u7ed3\u5408\u3002\u4f5c\u8005\u5728NEK9\u548cRAB30\u86cb\u767d\u4e0a\u8bc1\u660e\u4e86ABPP\u5b9e\u9a8c\u5f97\u5230\u7684\u87ba\u73af\u4e19\u70ef\u9170\u80fa\u7684\u4f4d\u70b9\u9009\u62e9\u6027\u548c\u7acb\u4f53\u9009\u62e9\u6027\u7ed3\u679c\u3002<\/section>\n<section><img decoding=\"async\" title=\"0\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20240409\/1712630755612066.png\" alt=\"0\" \/>\u200b<\/section>\n<section>\u6b64\u5916\uff0c\u4f5c\u8005\u8fd8\u89c2\u5bdf\u5230\u5728\u7ed3\u679c\u4e2d\uff0cERCC3\u86cb\u767d\u5728\u63a2\u9488\u5904\u74061 h\u540e\u6709ZL-14A\u7684\u663e\u8457\u7acb\u4f53\u9009\u62e9\u6027\u5bcc\u96c6\uff0c\u800c\u5728\u5904\u74063 h\u540e\u7acb\u4f53\u9009\u62e9\u6027\u5374\u660e\u663e\u964d\u4f4e\u3002\u4f5c\u8005\u731c\u6d4b\u539f\u56e0\u662f\u87ba\u73af\u4e19\u70ef\u9170\u80fa\u7684\u5171\u4ef7\u53cd\u5e94\u5bfc\u81f4ERCC3\u86cb\u767d\u964d\u89e3\uff0c\u5e76\u4e14\u901a\u8fc7Neddylation\u6291\u5236\u5242\u548c\u86cb\u767d\u8d28\u70b9\u7a81\u53d8\u7b49\u65b9\u5f0f\u8bc1\u660e\u4e86\u8fd9\u4e2a\u731c\u60f3\u3002\u6700\u540e\uff0c\u4f5c\u8005\u8fd8\u5bf9\u87ba\u73af\u4e19\u70ef\u9170\u80fa\u4e0e\u4e00\u79cd\u5929\u7136\u4ea7\u7269\u96f7\u516c\u85e4\u5185\u916f\u80fd\u5171\u4ef7\u7ed3\u5408ERCC3\u4e0a\u76f8\u540c\u7684\u534a\u80f1\u6c28\u9178\u6b8b\u57fa\u800c\u5177\u6709\u4e0d\u540c\u529f\u80fd\u7684\u673a\u5236\u8fdb\u884c\u4e86\u7814\u7a76\u3002<\/section>\n<section>\u603b\u7684\u6765\u8bf4\uff0c\u5728\u672c\u7bc7\u6587\u7ae0\u4e2d\u4f5c\u8005\u901a\u8fc7ABPP\u6280\u672f\u5bf9\u87ba\u73af\u4e19\u70ef\u9170\u80fa\u7acb\u4f53\u63a2\u9488\u8fdb\u884c\u4e86\u5316\u5b66\u86cb\u767d\u8d28\u7ec4\u5b66\u5206\u6790\uff0c\u9274\u5b9a\u5230\u4e86\u4e00\u79cdERCC3\u86cb\u767d\u7684\u5171\u4ef7\u964d\u89e3\u5242\u3002<\/section>\n<section>\u672c\u6587\u4f5c\u8005\uff1aLCX<\/section>\n<section>\u8d23\u4efb\u7f16\u8f91\uff1aZJ<\/section>\n<section>\u539f\u6587\u94fe\u63a5\uff1ahttps:\/\/pubs.acs.org\/doi\/10.1021\/jacs.3c13448<\/section>\n<section>\u6587\u7ae0\u5f15\u7528\uff1a10.1021\/jacs.3c13448<\/section>\n","protected":false},"excerpt":{"rendered":"<p>\u5206\u4eab\u4e00\u7bc7\u53d1\u8868\u5728JACS\u4e0a\u7684\u6587\u7ae0\uff1aProteomic Ligandability Maps of Spirocy [&hellip;]<\/p>\n","protected":false},"author":326,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[],"class_list":["post-51266","post","type-post","status-publish","format-standard","hentry","category-tuijianyuedu"],"_links":{"self":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/51266","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/users\/326"}],"replies":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/comments?post=51266"}],"version-history":[{"count":1,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/51266\/revisions"}],"predecessor-version":[{"id":51267,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/51266\/revisions\/51267"}],"wp:attachment":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/media?parent=51266"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/categories?post=51266"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/tags?post=51266"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}