{"id":51176,"date":"2024-04-08T08:32:46","date_gmt":"2024-04-08T00:32:46","guid":{"rendered":"https:\/\/www.chemhui.com\/?p=51176"},"modified":"2024-03-30T17:33:44","modified_gmt":"2024-03-30T09:33:44","slug":"org-lett-%e7%83%af%e5%9f%ba%e5%bc%82%e6%b0%b0%e9%85%b8%e9%85%af%e5%92%8c%e7%be%a7%e9%85%b8%e5%8f%8d%e5%ba%94%e8%84%b1%e7%be%a7%e7%94%9f%e6%88%90%e7%83%af%e9%85%b0%e8%83%ba","status":"publish","type":"post","link":"http:\/\/www.chemhui.com\/org-lett-%e7%83%af%e5%9f%ba%e5%bc%82%e6%b0%b0%e9%85%b8%e9%85%af%e5%92%8c%e7%be%a7%e9%85%b8%e5%8f%8d%e5%ba%94%e8%84%b1%e7%be%a7%e7%94%9f%e6%88%90%e7%83%af%e9%85%b0%e8%83%ba\/","title":{"rendered":"Org. Lett. | \u70ef\u57fa\u5f02\u6c30\u9178\u916f\u548c\u7fa7\u9178\u53cd\u5e94\u8131\u7fa7\u751f\u6210\u70ef\u9170\u80fa"},"content":{"rendered":"<p>\u5206\u4eab\u4e00\u7bc7\u8fd1\u671f\u53d1\u8868\u5728<em>Org<\/em><em>. Lett.<\/em>\u4e0a\u7684\u7814\u7a76\u8fdb\u5c55\uff0c\u9898\u4e3a\uff1aDecarboxylative Enamide Synthesis from Carboxylic Acid and\u00a0Alkenyl Isocyanate\u3002\u8be5\u5de5\u4f5c\u7684\u901a\u8baf\u4f5c\u8005\u662f\u6765\u81ea\u4e2d\u5c71\u5927\u5b66\u7684\u5218\u6587\u535a\u6559\u6388\u3002<\/p>\n<p>\u70ef\u9170\u80fa\uff0c\u5373N\u539f\u5b50\u8fde\u6709\u70ef\u57fa\u7684\u9170\u80fa\uff0c\u662f\u5929\u7136\u4ea7\u7269\u4e2d\u5b58\u5728\u7684\u91cd\u8981\u7ed3\u6784\uff0c\u4e5f\u662f\u6709\u673a\u5408\u6210\u4e2d\u7684\u5e38\u89c1\u4e2d\u95f4\u4f53\u3002\u4f20\u7edf\u65b9\u6cd5\u5408\u6210\u70ef\u9170\u80fa\u901a\u5e38\u9700\u8981\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u7684\u9170\u80faNH\u548c\u70ef\u57fa\u5364\u5316\u7269\u7684\u5076\u8054\u53cd\u5e94\uff0c\u6216\u662f\u9170\u80fa\u5bf9\u7094\u70c3\u7684\u52a0\u6210\u53cd\u5e94\uff0c\u4ee5\u53caLewis\u9178\u50ac\u5316\u7684\u9170\u80fa\u548c\u919b\u7684\u7f29\u5408\u53cd\u5e94\uff0c\u7b49\u7b49\uff08\u56fe1\uff0cA\uff09\u3002\u8fd9\u4e9b\u65b9\u6cd5\u5f80\u5f80\u9700\u8981\u5267\u70c8\u7684\u53cd\u5e94\u6761\u4ef6\u3001\u7279\u6b8a\u7684\u5219\u9700\u8981\u591a\u6b65\u5408\u6210\u7684\u5e95\u7269\u3001\u53d7\u9650\u7684\u5e95\u7269\u8303\u56f4\u548c\u6602\u8d35\u7684\u50ac\u5316\u5242\u3002\u7fa7\u9178\u548c\u80fa\u7684\u7f29\u5408\u53cd\u5e94\u662f\u9170\u80fa\u6700\u7b80\u5355\u76f4\u63a5\u7684\u751f\u6210\u65b9\u6cd5\uff0c\u7136\u800c\uff0c\u5bf9\u70ef\u9170\u80fa\u800c\u8a00\uff0c\u70ef\u80fa\u8fc7\u4e8e\u4e0d\u7a33\u5b9a\u7684\u6027\u8d28\u9650\u5236\u4e86\u6b64\u65b9\u6cd5\u7684\u5f00\u53d1\uff08\u56fe1\uff0cB\uff09\u3002\u91d1\u5c5e\u6709\u673a\u8bd5\u5242\u5bf9\u70ef\u57fa\u5f02\u6c30\u9178\u916f\u7684\u52a0\u6210\u53cd\u5e94\u662f\u53e6\u4e00\u79cd\u5236\u5907\u70ef\u9170\u80fa\u7684\u7b56\u7565\uff08\u56fe1\uff0cC\uff09\u3002\u7136\u800c\uff0c\u91d1\u5c5e\u6709\u673a\u8bd5\u5242\u7684\u7ed3\u6784\u591a\u6837\u6027\u4f4e\uff0c\u96be\u4e8e\u64cd\u4f5c\uff08\u901a\u5e38\u5bf9\u6c34\u6c27\u654f\u611f\uff09\uff0c\u4e14\u5b98\u80fd\u56e2\u5bb9\u5fcd\u6027\u8f83\u5dee\u3002\u56e0\u6b64\uff0c\u4f5c\u8005\u8ba4\u4e3a\uff0c\u6025\u9700\u5f00\u53d1\u4e00\u79cd\u539f\u6599\u6613\u5f97\u3001\u5e95\u7269\u8303\u56f4\u5e7f\u4e14\u64cd\u4f5c\u7b80\u4fbf\u7684\u65e0\u91d1\u5c5e\u70ef\u9170\u80fa\u5408\u6210\u7b56\u7565\u3002\u6b64\u524d\u7814\u7a76\u8868\u660e\uff0c\u7fa7\u9178\u548c\u5f02\u6c30\u9178\u916f\u5728DMAP\u50ac\u5316\u4e0b\u53ef\u4ee5\u5076\u8054\u751f\u6210\u9170\u80fa\u3002\u53d7\u6b64\u542f\u53d1\uff0c\u4f5c\u8005\u8bbe\u60f3\u7fa7\u9178\u548c\u70ef\u57fa\u5f02\u6c30\u9178\u916f\u7684\u53cd\u5e94\u5c06\u4f1a\u662f\u6f5c\u5728\u7684\u70ef\u9170\u80fa\u9ad8\u6548\u6784\u5efa\u7b56\u7565\uff08\u56fe1\uff0cD\uff09\u3002<\/p>\n<p>&nbsp;<\/p>\n<section><img decoding=\"async\" title=\"1\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20240315\/1710489198578299.png\" alt=\"1\" \/><\/section>\n<p>&nbsp;<\/p>\n<p><strong>\u56fe1.<\/strong>\u00a0\u7814\u7a76\u80cc\u666f\u548c\u672c\u5de5\u4f5c\u5185\u5bb9\u6982\u62ec<\/p>\n<p>\u70ef\u57fa\u5f02\u6c30\u9178\u916f\u53ef\u4ee5\u4ece<em>\u03b1,\u03b2<\/em>-\u4e0d\u9971\u548c\u9170\u57fa\u53e0\u6c2e\u7684Curtius\u91cd\u6392\u65b9\u4fbf\u5730\u5236\u5907\u3002\u4ee5\u6b64\u4e3a\u57fa\u7840\uff0c\u4f5c\u8005\u5c55\u5f00\u4e86\u521d\u59cb\u53cd\u5e94\u6761\u4ef6\u7b5b\u9009\uff08\u56fe2\uff09\u3002\u5411\u91cd\u6392\u7684\u53cd\u5e94\u6db2\u4e2d\u52a0\u5165DMAP\u548c\u7fa7\u9178\uff0c\u53cd\u5e942\u00a0h\u540e\uff0c\u4fbf\u53ef\u4ee570%\u4ea7\u7387\u5206\u79bb\u5f97\u5230\u70ef\u9170\u80fa\u4ea7\u7269\u3002\u5c06DMAP\u50ac\u5316\u5242\u66f4\u6362\u4e3a\u5176\u4ed6\u7269\u8d28\uff0c\u5982\u5421\u5576\u3001\u4e09\u4e59\u80fa\u548c\u54aa\u5511\u7b49\uff0c\u5747\u65e0\u6cd5\u7ed9\u51fa\u76ee\u6807\u4ea7\u7269\uff0c\u56e0\u6b64DMAP\u662f\u8be5\u53cd\u5e94\u6210\u529f\u7684\u5173\u952e\u3002\u6eb6\u5242\u65b9\u9762\uff0c\u4f4e\u6781\u6027\u7684\u7532\u82ef\u548c\u4e8c\u6c2f\u4e59\u70f7\u5747\u7ed9\u51fa70%\u5de6\u53f3\u7684\u4ea7\u7387\uff0c\u800c\u9ad8\u6781\u6027\u7684DMF\u548cDMSO\u65e0\u4ea7\u7269\u751f\u6210\u3002<\/p>\n<p>&nbsp;<\/p>\n<section><img decoding=\"async\" title=\"2\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20240315\/1710489213799086.png\" alt=\"2\" \/><\/section>\n<p>&nbsp;<\/p>\n<p><strong>\u56fe2.<\/strong>\u00a0\u53cd\u5e94\u6761\u4ef6\u7b5b\u9009<\/p>\n<p>\u4f7f\u7528\u4f18\u5316\u540e\u7684\u53cd\u5e94\u6761\u4ef6\uff0c\u4f5c\u8005\u5f00\u5c55\u4e86\u5e95\u7269\u8303\u56f4\u7684\u63a2\u7d22\uff08\u56fe3\uff09\u3002\u5e95\u7269\u6570\u91cf\u4f17\u591a\uff0c\u63a8\u9001\u7bc7\u5e45\u6709\u9650\uff0c\u8bf7\u611f\u5174\u8da3\u8005\u9605\u8bfb\u539f\u6587\u732e\u3002<\/p>\n<p>&nbsp;<\/p>\n<section><img decoding=\"async\" title=\"3\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20240315\/1710489225237609.png\" alt=\"3\" \/><\/section>\n<p>&nbsp;<\/p>\n<p><strong>\u56fe3.<\/strong>\u00a0\u7fa7\u9178\u548c\u70ef\u57fa\u5f02\u6c30\u9178\u916f\u7684\u5e95\u7269\u8303\u56f4<\/p>\n<p>\u53cd\u5e94\u751f\u6210\u7684\u70ef\u9170\u80fa4p\u53ef\u4ee5\u53d1\u751f\u4e00\u7cfb\u5217\u5316\u5b66\u8f6c\u5316\uff0c\u5f97\u5230\u591a\u79cd\u6709\u4ef7\u503c\u7684\u5206\u5b50\u7ed3\u6784\uff08\u56fe4\uff09\u3002<\/p>\n<p>&nbsp;<\/p>\n<section><img decoding=\"async\" title=\"4\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20240315\/1710489235855753.png\" alt=\"4\" \/><\/section>\n<p>&nbsp;<\/p>\n<p><strong>\u56fe4.<\/strong>\u00a0\u70ef\u9170\u80fa\u4ea7\u7269\u7684\u5408\u6210\u5e94\u7528<\/p>\n<p>\u4e3a\u4e86\u6df1\u5165\u7406\u89e3\u4e0a\u8ff0\u53cd\u5e94\u8fc7\u7a0b\uff0c\u4f5c\u8005\u5f00\u5c55\u4e86\u5982\u4e0b\u7684\u673a\u7406\u5b9e\u9a8c\uff08\u56fe5\uff09\u3002\u9996\u5148\uff0c\u4ed6\u4eec\u4f7f\u7528GC\u68c0\u6d4b\u53cd\u5e94\u8fc7\u7a0b\uff0c\u786e\u8ba4\u4e86CO<sub>2<\/sub>\u7684\u91ca\u653e\uff08\u56fe5\uff0cA\uff09\u3002\u968f\u540e\uff0c\u4ed6\u4eec\u7814\u7a76\u4e86\u53cd\u5e94\u901f\u7387\u548c\u53d6\u4ee3\u82ef\u7532\u9178\u7684\u53d6\u4ee3\u57fa\u7535\u5b50\u6548\u5e94\u7684\u5173\u7cfb\uff0c\u53d1\u73b0\u8d8a\u7f3a\u7535\u5b50\u7684\u7fa7\u9178\u53cd\u5e94\u901f\u7387\u8d8a\u5feb\uff08\u56fe5\uff0cB\uff09\u3002\u8fd9\u8bf4\u660e\uff0c\u5728\u53cd\u5e94\u51b3\u901f\u6b65\u8fc7\u6e21\u6001\u4e2d\u51fa\u73b0\u4e86\u8d1f\u7535\u8377\u7684\u79ef\u7d2f\uff0c\u5438\u7535\u5b50\u53d6\u4ee3\u57fa\u6709\u52a9\u4e8e\u7a33\u5b9a\u8d1f\u7535\u8377\uff0c\u52a0\u5feb\u53cd\u5e94\u8fdb\u884c\u3002\u4f5c\u8005\u4e5f\u5f00\u5c55\u4e86\u540c\u4f4d\u7d20\u6807\u8bb0\u5b9e\u9a8c\uff0c\u4f7f\u7528<sup>1<\/sup><sup>8<\/sup>O\u6807\u8bb0\u7684\u82ef\u7532\u9178\u4f5c\u4e3a\u53cd\u5e94\u5e95\u7269\uff0c\u6700\u7ec8\u4ea7\u7269\u548cCO<sub>2<\/sub>\u5747\u542b\u6709\u4e00\u4e2a<sup>1<\/sup><sup>8<\/sup>O\u539f\u5b50\uff08\u56fe5\uff0cC\uff09\u3002\u57fa\u4e8e\u4e0a\u8ff0\u5b9e\u9a8c\u7ed3\u679c\uff0c\u4f5c\u8005\u63d0\u51fa\u4e86\u4e00\u79cd\u53ef\u80fd\u673a\u7406\uff08\u56fe5\uff0cD\uff09\u3002DMAP\u9996\u5148\u548c\u5f02\u6c30\u9178\u916f\u53cd\u5e94\uff0c\u4ea7\u751f\u4e2d\u95f4\u4f5312\uff0c\u540e\u8005\u5c06\u7fa7\u9178\u53bb\u8d28\u5b50\u5f97\u523013\u548c\u5bf9\u5e94\u7684\u7fa7\u9178\u8d1f\u79bb\u5b50\uff0c\u4e8c\u8005\u968f\u540e\u53cd\u5e94\u5f97\u5230<em>N<\/em>-\u7fa7\u57fa\u9178\u915014\u3002\u4f5c\u8005\u8ba4\u4e3a14\u53ef\u4ee5\u901a\u8fc7\u4e00\u4e2a\u9ad8\u5f20\u529b\u7684\u56db\u5143\u73afTS\uff0815\uff09\u7ed9\u51fa\u6700\u540e\u7684\u53cd\u5e94\u4ea7\u7269\uff0c\u540c\u65f6\u8fd9\u4e5f\u662f\u6574\u4e2a\u53cd\u5e94\u7684\u51b3\u901f\u6b65\u3002<\/p>\n<p>&nbsp;<\/p>\n<section><img decoding=\"async\" title=\"5\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20240315\/1710489250603863.png\" alt=\"5\" \/><\/section>\n<p>&nbsp;<\/p>\n<p><strong>\u56fe5.<\/strong>\u00a0\u673a\u7406\u5b9e\u9a8c\u548c\u53ef\u80fd\u673a\u7406<\/p>\n<p>\u7efc\u4e0a\uff0c\u4f5c\u8005\u57fa\u4e8eDMAP\u50ac\u5316\u7684\u5f02\u6c30\u9178\u916f\u548c\u7fa7\u9178\u7684\u5076\u8054\u53cd\u5e94\uff0c\u5b9e\u73b0\u4e86\u70ef\u9170\u80fa\u7684\u7b80\u4fbf\u5408\u6210\u3002<\/p>\n<p><strong>\u4f5c\u8005\uff1a<\/strong>WS\u00a0\u00a0<strong>\u5ba1\u6821\uff1a<\/strong>XRZ<\/p>\n<p><strong>DOI<\/strong><strong>:\u00a0<\/strong>10.1021\/acs.orglett.3c01682<\/p>\n<p><strong>Link:<\/strong>\u00a0https:\/\/doi.org\/10.1021\/acs.orglett.3c01682<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5206\u4eab\u4e00\u7bc7\u8fd1\u671f\u53d1\u8868\u5728Org. Lett.\u4e0a\u7684\u7814\u7a76\u8fdb\u5c55\uff0c\u9898\u4e3a\uff1aDecarboxylative Enamide Sy [&hellip;]<\/p>\n","protected":false},"author":326,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[],"class_list":["post-51176","post","type-post","status-publish","format-standard","hentry","category-tuijianyuedu"],"_links":{"self":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/51176","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/users\/326"}],"replies":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/comments?post=51176"}],"version-history":[{"count":1,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/51176\/revisions"}],"predecessor-version":[{"id":51177,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/51176\/revisions\/51177"}],"wp:attachment":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/media?parent=51176"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/categories?post=51176"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/tags?post=51176"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}