{"id":51111,"date":"2024-03-30T08:28:14","date_gmt":"2024-03-30T00:28:14","guid":{"rendered":"https:\/\/www.chemhui.com\/?p=51111"},"modified":"2024-03-21T10:30:12","modified_gmt":"2024-03-21T02:30:12","slug":"%e3%80%90acs-catal-%e3%80%91%e8%bf%87%e6%b0%a7%e9%85%b6%e5%82%ac%e5%8c%96%e7%83%af%e4%b8%99%e5%9f%ba%e6%b0%a7%e5%8c%96%e8%a7%a3%e9%94%811s-3r-3-%e7%be%9f%e5%9f%ba%e7%8e%af%e5%b7%b1%e7%83%b7","status":"publish","type":"post","link":"http:\/\/www.chemhui.com\/%e3%80%90acs-catal-%e3%80%91%e8%bf%87%e6%b0%a7%e9%85%b6%e5%82%ac%e5%8c%96%e7%83%af%e4%b8%99%e5%9f%ba%e6%b0%a7%e5%8c%96%e8%a7%a3%e9%94%811s-3r-3-%e7%be%9f%e5%9f%ba%e7%8e%af%e5%b7%b1%e7%83%b7\/","title":{"rendered":"\u3010ACS Catal.\u3011\u8fc7\u6c27\u9176\u50ac\u5316\u70ef\u4e19\u57fa\u6c27\u5316\u89e3\u9501(1S, 3R)-3-\u7f9f\u57fa\u73af\u5df1\u70f7\u8148\u7684\u8fdc\u7a0b\u5408\u6210"},"content":{"rendered":"<p><img decoding=\"async\" title=\"1\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20240321\/1710988140714473.png\" alt=\"1\" \/><\/p>\n<p>\u751f\u7269\u50ac\u5316\u9886\u57df\u5df2\u7ecf\u63ed\u793a\u4e86\u9176\u5728\u83b7\u5f97\u9ad8\u7eaf\u5ea6\u624b\u6027\u6d3b\u6027\u836f\u7269\u6210\u5206\uff08API\uff09\u65b9\u9762\u5177\u6709\u65e0\u4e0e\u4f26\u6bd4\u7684\u9009\u62e9\u6027\uff0c\u751a\u81f3\u4e0e\u5316\u5b66\u65b9\u6cd5\u76f8\u6bd4\uff0c\u8fd9\u662f\u4e00\u79cd\u5408\u6210\u6377\u5f84\u3002\u5728\u8fd9\u65b9\u9762\uff0c\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u516c\u53f8\uff08BMS\uff09\u6700\u8fd1\u516c\u5f00\u4e86\u6eb6\u8840\u78f7\u8102\u9178\u53d7\u4f53LPA1\u62ee\u6297\u5242BMS-986278\uff0c\u5176\u76ee\u524d\u6b63\u5904\u4e8e\u6cbb\u7597\u7279\u53d1\u6027\u80ba\u7ea4\u7ef4\u5316\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u3002BMS-986278\u542b\u6709\u4e24\u4e2a\u7acb\u4f53\u4e2d\u5fc3\uff0c\u5728\u53d1\u73b0\u5408\u6210\u8fc7\u7a0b\u4e2d\uff0c\u5b83\u4eec\u4ee5\u975e\u5bf9\u6620\u9009\u62e9\u6027\u7684\u65b9\u5f0f\u4ece\u624b\u6027\u8d77\u59cb\u6750\u6599\uff08S\uff09-3-\u73af\u5df1\u70ef\u7fa7\u9178\u884d\u751f\u800c\u6765\uff0c\u9700\u8981\u5176\u5916\u6d88\u65cb\u4f53\u7684\u7ecf\u5178\u62c6\u5206\uff0c\u9020\u6210\u4e86\u56fa\u6709\u7684\u6d6a\u8d39\u3002\u56e0\u6b64\uff0c\u7531\u524d\u624b\u6027\u8d77\u59cb\u6750\u6599\u8fdb\u884c\u7684\u66ff\u4ee3\u5408\u6210\u662f\u4f18\u9009\u7684\uff0c\u4f46\u5728\u5316\u5b66\u53cd\u5e94\u4e2d\u5b9e\u73b0\u9ad8\u7acb\u4f53\u504f\u597d\u5177\u6709\u4e00\u5b9a\u7684\u6311\u6218\u6027\uff0c\u5e76\u4e14\u901a\u5e38\u4f7f\u7528\u5177\u6709\u624b\u6027\u914d\u4f53\u7684\u7a00\u6709\u91d1\u5c5e\u50ac\u5316\u5242\u6765\u5b9e\u73b0\uff0c\u8fd9\u4e9b\u624b\u6027\u914d\u4f53\u7684\u5408\u6210\u901a\u5e38\u5341\u5206\u590d\u6742\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u9176\u5177\u6709\u9ad8\u5ea6\u7684\u5316\u5b66\u3001\u533a\u57df\u548c\u7acb\u4f53\u9009\u62e9\u6027\uff0c\u53ef\u4ee5\u5f88\u5bb9\u6613\u5730\u4ece\u751f\u7269\u53ef\u518d\u751f\u6210\u5206\u4e2d\u4ea7\u751f\uff0c\u540c\u65f6\u4ea7\u751f\u53ef\u751f\u7269\u964d\u89e3\u7684\u5e9f\u7269\u3002\u5f00\u53d1\u624b\u6027\u4e2d\u95f4\u4f53(1S, 3R)-3-\u7f9f\u57fa\u73af\u5df1\u70f7\u8148(5)\u7684\u9006\u5408\u6210\uff0c\u5229\u7528\u9187\u8131\u6c22\u9176\uff08ADHs\uff09\u50ac\u5316\u7684\u4e0d\u5bf9\u79f0\u916e\u8fd8\u539f\u5df2\u5728\u5de5\u4e1a\u89c4\u6a21\u4e0a\u5f97\u5230\u5f88\u597d\u7684\u5efa\u7acb\u548c\u5b9e\u65bd\uff0c\u5e76\u53ef\u4ee5\u4ece\u4e2d\u95f4\u4f53S-3-\u7fb0\u57fa\u73af\u5df1\u70f7\u8148(4)\u83b7\u5f97(1S, 3R)-3-\u7f9f\u57fa\u73af\u5df1\u70f7\u8148(5)\u3002<\/p>\n<p><img decoding=\"async\" title=\"2\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20240321\/1710988150415648.png\" alt=\"2\" \/><\/p>\n<p>\u56fe\u7247\u6765\u6e90\uff1aACS Catal.<\/p>\n<p>\u8fd1\u671f\uff0cDelft University of Technology\u7684Caroline E. Paul\u8bfe\u9898\u7ec4\u53d7\u5230LPA1\u62ee\u6297\u5242BMS-986278\u53d1\u73b0\u5408\u6210\u9014\u5f84\u7684\u542f\u53d1\uff0c\u4f7f\u7528\u70ef\u8fd8\u539f\u9176\uff08ER\uff09\u548c\u9187\u8131\u6c22\u9176\uff08ADH\uff09\u6765\u8bbe\u7f6e\u4e24\u4e2a\u7acb\u4f53\u4e2d\u5fc3\uff0c\u5e76\u8bbe\u60f3\u4f7f\u7528API\u6784\u5efa(1S, 3R)-3-\u7f9f\u57fa\u73af\u5df1\u70f7\u8148\u3002\u7136\u800c\uff0c\u4ece\u5e02\u552e\u7684\u73af\u5df1\u70ef-1-\u8148\u5f00\u59cb\uff0c\u9700\u8981C\u2212H\u6c27\u5b98\u80fd\u5316\u6b65\u9aa4\u6765\u5f15\u5165\u916e\u5b98\u80fd\u56e2\uff0c\u4f46\u51e0\u79cd\u5316\u5b66\u70ef\u4e19\u57fa\u6c27\u5316\u7b56\u7565\u6ca1\u6709\u6210\u529f\u5b9e\u73b0\u8fd9\u4e00\u53cd\u5e94\u3002\u6b64\u5916\uff0c\u70ef\u4e19\u57fa\u6c27\u5316\u7684\u9176\u7b56\u7565\u5c1a\u4e0d\u6210\u719f\uff0c\u7ec6\u80de\u8272\u7d20P450\u548c\u975e\u7279\u5f02\u6027\u8fc7\u6c27\u9176\uff08UPOs\uff09\u7684\u9009\u5b9a\u5e95\u7269\u50ac\u5316\u7684\u4f8b\u5b50\u62a5\u9053\u5730\u5f88\u5c11\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u8be5\u7814\u7a76\u53d1\u73b0UPOs\u5728\u4e0d\u6dfb\u52a0\u6709\u673a\u5171\u6eb6\u5242\u7684\u60c5\u51b5\u4e0b\uff0c\u5728\u9ad8\u8fbe200mM\u7684\u5e95\u7269\u8d1f\u8f7d\u4e0b\uff0c\u4ee5\u9ad8\u5316\u5b66\u9009\u62e9\u6027\u548c\u533a\u57df\u9009\u62e9\u6027\u50ac\u5316\u6240\u9700\u7684\u70ef\u4e19\u57fa\u6c27\u5316\uff0c\u4ece\u800c\u80fd\u591f\u5728\u4e09\u6b65\u4e00\u9505\u7ea7\u8054\u4e2d\u8fdb\u884c\u968f\u540e\u7684ER\u548cADH\u6b65\u9aa4\u3002UPOs\u751a\u81f3\u663e\u793a\u51fa\u4ece\u672a\u62a5\u9053\u7684\u53d6\u4ee3\u73af\u5df1\u70ef\u7684\u5bf9\u6620\u9009\u62e9\u6027\u6c27\u5b98\u80fd\u5316\u548c\u8fc7\u6c27\u5316\u3002\u5728\u7b5b\u9009\u9176\u677f\u540e\uff0c\u5728\u5e95\u7269\u8d1f\u8f7d\u91cf\u4e3a50mM\uff0cER\u662f\u9650\u5236\u6b65\u9aa4\u7684\u60c5\u51b5\u4e0b\uff0c\u4ee597%ee\u548c99%de\u768485%\u6ef4\u5ea6\u83b7\u5f97\u6700\u7ec8\u4ea7\u7269\u3002\u603b\u4e4b\uff0c\u8fd9\u79cd\u5408\u6210\u65b9\u6cd5\u63d0\u4f9b\u4e86\u4e09\u6b65\u4e00\u9505UPO-ER-ADH\u7ea7\u8054\u7684\u7b2c\u4e00\u4e2a\u4f8b\u5b50\uff0c\u5e76\u7a81\u51fa\u4e86UPOs\u50ac\u5316\u4e0d\u540c\u5bf9\u6620\u9009\u62e9\u6027\u70ef\u4e19\u57fa\u7f9f\u57fa\u5316\u548c\u6c27\u5316\u7684\u6f5c\u529b\u3002<\/p>\n<p><img decoding=\"async\" title=\"8\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20240321\/1710988162722757.png\" alt=\"8\" \/>\u200b<\/p>\n<p>\u56fe\u7247\u6765\u6e90\uff1aACS Catal.<\/p>\n<p>\u539f\u6587\u6807\u9898\uff1aPeroxygenase-Catalyzed Allylic Oxidation Unlocks Telescoped Synthesis of (1S,3R)\u20113-Hydroxycyclohexanecarbonitrile<\/p>\n<p>\u539f\u6587\u4f5c\u8005\uff1aChristian M. Heckmann, Moritz Bu\u0308rgler, and Caroline E. Paul*<\/p>\n<p>ACS Catal. 2024, 14, 2985\u22122991<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u751f\u7269\u50ac\u5316\u9886\u57df\u5df2\u7ecf\u63ed\u793a\u4e86\u9176\u5728\u83b7\u5f97\u9ad8\u7eaf\u5ea6\u624b\u6027\u6d3b\u6027\u836f\u7269\u6210\u5206\uff08API\uff09\u65b9\u9762\u5177\u6709\u65e0\u4e0e\u4f26\u6bd4\u7684\u9009\u62e9\u6027\uff0c\u751a\u81f3\u4e0e\u5316\u5b66\u65b9\u6cd5\u76f8\u6bd4\uff0c\u8fd9 [&hellip;]<\/p>\n","protected":false},"author":326,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[],"class_list":["post-51111","post","type-post","status-publish","format-standard","hentry","category-tuijianyuedu"],"_links":{"self":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/51111","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/users\/326"}],"replies":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/comments?post=51111"}],"version-history":[{"count":1,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/51111\/revisions"}],"predecessor-version":[{"id":51112,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/51111\/revisions\/51112"}],"wp:attachment":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/media?parent=51111"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/categories?post=51111"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/tags?post=51111"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}