{"id":50842,"date":"2024-02-24T08:40:48","date_gmt":"2024-02-24T00:40:48","guid":{"rendered":"https:\/\/www.chemhui.com\/?p=50842"},"modified":"2024-02-15T14:41:59","modified_gmt":"2024-02-15T06:41:59","slug":"%e3%80%90j-am-chem-soc-%e3%80%91proteinmpnn%e6%94%b9%e5%96%84%e8%9b%8b%e7%99%bd%e8%b4%a8%e8%a1%a8%e8%be%be%e3%80%81%e7%a8%b3%e5%ae%9a%e6%80%a7%e5%92%8c%e5%8a%9f%e8%83%bd","status":"publish","type":"post","link":"http:\/\/www.chemhui.com\/%e3%80%90j-am-chem-soc-%e3%80%91proteinmpnn%e6%94%b9%e5%96%84%e8%9b%8b%e7%99%bd%e8%b4%a8%e8%a1%a8%e8%be%be%e3%80%81%e7%a8%b3%e5%ae%9a%e6%80%a7%e5%92%8c%e5%8a%9f%e8%83%bd\/","title":{"rendered":"\u3010J. Am. Chem. Soc.\u3011ProteinMPNN\u6539\u5584\u86cb\u767d\u8d28\u8868\u8fbe\u3001\u7a33\u5b9a\u6027\u548c\u529f\u80fd"},"content":{"rendered":"<p><img decoding=\"async\" title=\"1\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20240211\/1707642511168937.png\" alt=\"1\" \/><\/p>\n<p>\u5929\u7136\u86cb\u767d\u8d28\u7684\u529f\u80fd\u662f\u9ad8\u5ea6\u4f18\u5316\u7684\uff0c\u4f46\u7531\u4e8e\u5728\u5f02\u6e90\u7cfb\u7edf\u4e2d\u8868\u8fbe\u5dee\u3001\u6eb6\u89e3\u5ea6\u6709\u9650\u548c\u5bf9\u6e29\u5ea6\u7684\u654f\u611f\u6027\uff0c\u901a\u5e38\u96be\u4ee5\u4ee5\u9002\u5408\u751f\u7269\u6280\u672f\u5e94\u7528\u7684\u89c4\u6a21\u5316\u751f\u4ea7\u3002\u6709\u9274\u4e8e\u6b64\uff0cUniversity of Washington\u7684David Baker\u8bfe\u9898\u7ec4\u5f00\u53d1\u4e86\u4e00\u79cd\u5728\u4fdd\u6301\u529f\u80fd\u7684\u540c\u65f6\u6539\u5584\u5929\u7136\u86cb\u767d\u8d28\u7269\u7406\u6027\u8d28\u7684\u901a\u7528\u65b9\u6cd5\uff0c\u8be5\u65b9\u6cd5\u57fa\u4e8e\u6df1\u5ea6\u795e\u7ecf\u7f51\u7edcProteinMPNN\uff0c\u4ee5\u53ca\u7ed3\u5408\u8fdb\u5316\u548c\u7ed3\u6784\u4fe1\u606f\uff0c\u4e3a\u589e\u52a0\u86cb\u767d\u8d28\u8868\u8fbe\u3001\u7a33\u5b9a\u6027\u548c\u529f\u80fd\u63d0\u4f9b\u4e86\u4e00\u6761\u9014\u5f84\u3002\u8fd9\u79cd\u65b9\u6cd5\u53ef\u80fd\u5bf9\u57fa\u4e8e\u86cb\u767d\u8d28\u7684\u6280\u672f\u5177\u6709\u5e7f\u6cdb\u7684\u5b9e\u7528\u6027\u3002<\/p>\n<p><img decoding=\"async\" title=\"2\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20240211\/1707642518809415.png\" alt=\"2\" \/><\/p>\n<p>\u56fe\u7247\u6765\u6e90\uff1aJ. Am. Chem. Soc.<\/p>\n<p>\u5c06\u8be5\u65b9\u6cd5\u7528\u4e8e\u808c\u7ea2\u86cb\u767dMb\u7684\u5206\u5b50\u6539\u9020\uff0c\u901a\u8fc7\u8bbe\u8ba1\u540e\u83b7\u5f97\u7684\u7a81\u53d8\u4f53\u5176\u8868\u8fbe\u91cf\u5f97\u5230\u4e86\u63d0\u9ad8\u3001\u540c\u65f6\u5176T<sub>m<\/sub>\u6e29\u5ea6\u4e5f\u63d0\u9ad8\u4e86\uff0c\u8868\u660e\u5176\u7a33\u5b9a\u6027\u5f97\u5230\u4e86\u663e\u8457\u6539\u5584\u3002<\/p>\n<p><img decoding=\"async\" title=\"3\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20240211\/1707642525875149.png\" alt=\"3\" \/><\/p>\n<p>\u56fe\u7247\u6765\u6e90\uff1aJ. Am. Chem. Soc.<\/p>\n<p>\u6b64\u5916\uff0c\u540c\u6837\u5bf9\u86cb\u767d\u9176TEV\u8fdb\u884c\u8bbe\u8ba1\uff0c\u4e0d\u4ec5\u8868\u8fbe\u91cf\u548cT<sub>m<\/sub>\u6e29\u5ea6\u5f97\u5230\u4e86\u6539\u5584\uff0c\u4e0e\u4eb2\u672c\u5e8f\u5217\u548c\u5df2\u62a5\u9053\u7684TEV\u7a81\u53d8\u4f53\u76f8\u6bd4\u5176\u50ac\u5316\u6d3b\u6027\u4e5f\u5f97\u5230\u4e86\u6539\u8fdb\u3002\u603b\u4e4b\uff0c\u8fd9\u79cd\u65b9\u6cd5\u5bf9\u6539\u5584\u751f\u7269\u6280\u672f\u4e0a\u91cd\u8981\u86cb\u767d\u8d28\u7684\u8868\u8fbe\u3001\u7a33\u5b9a\u6027\u548c\u529f\u80fd\u5177\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\u524d\u666f\u3002<\/p>\n<p><img decoding=\"async\" title=\"0\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20240211\/1707642533455211.png\" alt=\"0\" \/><\/p>\n<p>\u56fe\u7247\u6765\u6e90\uff1aJ. Am. Chem. Soc.<\/p>\n<p>\u539f\u6587\u6807\u9898\uff1aImproving Protein Expression, Stability, and Function with ProteinMPNN<\/p>\n<p>\u539f\u6587\u4f5c\u8005\uff1aKiera H. Sumida, Reyes Nu\u0301n\u0303ez-Franco, Indrek Kalvet, Samuel J. Pellock, Basile I. M. Wicky, Lukas F. Milles, Justas Dauparas, Jue Wang, Yakov Kipnis, Noel Jameson, Alex Kang, Joshmyn De La Cruz, Banumathi Sankaran, Asim K. Bera, Gonzalo Jim\u00e9nez-Os\u00e9s, and David Baker*<\/p>\n<p>\u539f\u6587\u94fe\u63a5\uff1ahttps:\/\/doi.org\/10.1021\/jacs.3c10941<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5929\u7136\u86cb\u767d\u8d28\u7684\u529f\u80fd\u662f\u9ad8\u5ea6\u4f18\u5316\u7684\uff0c\u4f46\u7531\u4e8e\u5728\u5f02\u6e90\u7cfb\u7edf\u4e2d\u8868\u8fbe\u5dee\u3001\u6eb6\u89e3\u5ea6\u6709\u9650\u548c\u5bf9\u6e29\u5ea6\u7684\u654f\u611f\u6027\uff0c\u901a\u5e38\u96be\u4ee5\u4ee5\u9002\u5408\u751f\u7269\u6280\u672f\u5e94\u7528 [&hellip;]<\/p>\n","protected":false},"author":326,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[],"class_list":["post-50842","post","type-post","status-publish","format-standard","hentry","category-tuijianyuedu"],"_links":{"self":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/50842","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/users\/326"}],"replies":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/comments?post=50842"}],"version-history":[{"count":1,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/50842\/revisions"}],"predecessor-version":[{"id":50843,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/50842\/revisions\/50843"}],"wp:attachment":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/media?parent=50842"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/categories?post=50842"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/tags?post=50842"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}