{"id":50818,"date":"2024-02-20T08:01:16","date_gmt":"2024-02-20T00:01:16","guid":{"rendered":"https:\/\/www.chemhui.com\/?p=50818"},"modified":"2024-02-11T17:03:06","modified_gmt":"2024-02-11T09:03:06","slug":"%e3%80%90nat-chem-biol-%e3%80%91%e9%9d%92%e9%9c%89%e7%b4%a0%e7%bb%93%e5%90%88%e8%9b%8b%e7%99%bd%e5%9e%8b%e7%a1%ab%e9%85%af%e9%85%b6%e5%af%b9%e5%b0%8f%e5%88%86%e5%ad%90%e5%86%85%e9%85%b0%e8%83%ba","status":"publish","type":"post","link":"http:\/\/www.chemhui.com\/%e3%80%90nat-chem-biol-%e3%80%91%e9%9d%92%e9%9c%89%e7%b4%a0%e7%bb%93%e5%90%88%e8%9b%8b%e7%99%bd%e5%9e%8b%e7%a1%ab%e9%85%af%e9%85%b6%e5%af%b9%e5%b0%8f%e5%88%86%e5%ad%90%e5%86%85%e9%85%b0%e8%83%ba\/","title":{"rendered":"\u3010Nat. Chem. Biol.\u3011\u9752\u9709\u7d20\u7ed3\u5408\u86cb\u767d\u578b\u786b\u916f\u9176\u5bf9\u5c0f\u5206\u5b50\u5185\u9170\u80fa\u7684\u751f\u7269\u50ac\u5316\u73af\u5316\u53cd\u5e94"},"content":{"rendered":"<p><img decoding=\"async\" title=\"1\" src=\"https:\/\/10110.seohost.cn\/storage\/10110\/article\/20240211\/1707642136902604.png\" alt=\"1\" \/><\/p>\n<p>\u5927\u73af\u80bd\u662f\u4e00\u79cd\u7528\u4e8e\u5316\u5b66\u5de5\u5177\u548c\u6f5c\u5728\u6cbb\u7597\u7684\u6709\u524d\u666f\u7684\u652f\u67b6\u3002\u80bd\u7684\u5927\u73af\u5316\u5408\u6210\u65b9\u6cd5\u7ecf\u5e38\u53d7\u5230C\u672b\u7aef\u5dee\u5411\u5f02\u6784\u5316\u548c\u4f4e\u805a\u7684\u963b\u788d\uff0c\u5bfc\u81f4\u5176\u5e94\u7528\u96be\u4ee5\u6269\u5c55\u3002\u867d\u7136\u5b58\u5728\u89c4\u907f\u8fd9\u4e00\u95ee\u9898\u7684\u5316\u5b66\u7b56\u7565\uff0c\u4f46\u5b83\u4eec\u901a\u5e38\u9700\u8981\u7279\u5b9a\u7684\u6c28\u57fa\u9178\u5b58\u5728\u4e8e\u80bd\u5e8f\u5217\u4e2d\u3002<\/p>\n<p>\u6709\u9274\u4e8e\u6b64\uff0cPurdue University\u7684Elizabeth I. Parkinson\u62a5\u9053\u4e86\u4e00\u79cd\u80bd\u73af\u5316\u9176Ulm16,\u50ac\u5316\u975e\u6838\u7cd6\u6838\u9178\u80bd\u4ece\u5934\u5230\u5c3e\u7684\u5927\u5185\u9170\u80fa\u5316\uff0cUlm16\u5c5e\u4e8e\u9752\u9709\u7d20\u7ed3\u5408\u86cb\u767d\u7c7b\u786b\u916f\u9176\uff0c\u53c2\u4e0e\u5230Ulleungmycin A\u7684\u751f\u7269\u5408\u6210\u3002<\/p>\n<p><img decoding=\"async\" title=\"2\" src=\"https:\/\/10110.seohost.cn\/storage\/10110\/article\/20240211\/1707642143729231.png\" alt=\"2\" \/><\/p>\n<p>\u56fe\u7247\u6765\u6e90\uff1aNat. Chem. Biol.<\/p>\n<p>Ulm16\u6709\u6548\u5730\u73af\u53164\u81f36\u4e2a\u6c28\u57fa\u9178\u7684\u5404\u79cd\u975e\u5929\u7136\u80bd\uff0c\u50ac\u5316\u6548\u7387\u9ad8\u8fbe3\u00d710<sup>6<\/sup>\u00a0M<sup>\u22121<\/sup>\u00a0s<sup>\u22121<\/sup>\u3002\u4e0e\u4e4b\u524d\u62a5\u9053\u7684\u8bb8\u591a\u540c\u6e90\u86cb\u767d\u4e0d\u540c\uff0cUlm16\u8010\u53d7\u591a\u79cdC\u7aef\u548cN\u7aef\u6c28\u57fa\u9178\u3002<\/p>\n<p><img decoding=\"async\" title=\"3\" src=\"https:\/\/10110.seohost.cn\/storage\/10110\/article\/20240211\/1707642150868247.png\" alt=\"3\" \/><\/p>\n<p>\u56fe\u7247\u6765\u6e90\uff1aNat. Chem. Biol.<\/p>\n<p>\u968f\u540e\u89e3\u6790\u4e86Ulm16\u7684\u6676\u4f53\u7ed3\u6784\uff0c\u4ee5\u53ca\u5176\u5e95\u7269\u7684\u5efa\u6a21\u548c\u5b9a\u70b9\u8bf1\u53d8\uff0c\u4f7f\u8fd9\u79cd\u5e7f\u6cdb\u7684\u5e95\u7269\u8303\u56f4\u6027\u8d28\u5728\u7ed3\u6784\u4e0a\u8fdb\u884c\u4e86\u5408\u7406\u7684\u89e3\u91ca\u3002\u603b\u4e4b\uff0cUlm16\u4ee3\u8868\u4e86\u4e00\u79cd\u7528\u4e8e\u751f\u7269\u50ac\u5316\u751f\u4ea7\u5927\u73af\u80bd\u7684\u6709\u524d\u9014\u7684\u5de5\u5177\u3002<\/p>\n<p><img decoding=\"async\" title=\"9\" src=\"https:\/\/10110.seohost.cn\/storage\/10110\/article\/20240211\/1707642162904597.png\" alt=\"9\" \/>\u200b<\/p>\n<p>\u56fe\u7247\u6765\u6e90\uff1aNat. Chem. Biol.<\/p>\n<p>\u539f\u6587\u6807\u9898\uff1aBiocatalytic cyclization of small macrolactams by a penicillin-binding protein-type thioesterase<\/p>\n<p>\u539f\u6587\u4f5c\u8005\uff1aZachary L. Budimir, Rishi S. Patel, Alyssa Eggly, Claudia N. Evans, Hannah M. Rondon-Cordero, Jessica J. Adams, Chittaranjan Das &amp; Elizabeth I. Parkinson*<\/p>\n<p>\u539f\u6587\u94fe\u63a5\uff1ahttps:\/\/doi.org\/10.1038\/s41589-023-01495-z<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5927\u73af\u80bd\u662f\u4e00\u79cd\u7528\u4e8e\u5316\u5b66\u5de5\u5177\u548c\u6f5c\u5728\u6cbb\u7597\u7684\u6709\u524d\u666f\u7684\u652f\u67b6\u3002\u80bd\u7684\u5927\u73af\u5316\u5408\u6210\u65b9\u6cd5\u7ecf\u5e38\u53d7\u5230C\u672b\u7aef\u5dee\u5411\u5f02\u6784\u5316\u548c\u4f4e\u805a\u7684\u963b\u788d\uff0c\u5bfc\u81f4 [&hellip;]<\/p>\n","protected":false},"author":326,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[],"class_list":["post-50818","post","type-post","status-publish","format-standard","hentry","category-tuijianyuedu"],"_links":{"self":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/50818","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/users\/326"}],"replies":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/comments?post=50818"}],"version-history":[{"count":1,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/50818\/revisions"}],"predecessor-version":[{"id":50819,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/50818\/revisions\/50819"}],"wp:attachment":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/media?parent=50818"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/categories?post=50818"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/tags?post=50818"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}