{"id":50740,"date":"2024-02-07T08:09:52","date_gmt":"2024-02-07T00:09:52","guid":{"rendered":"https:\/\/www.chemhui.com\/?p=50740"},"modified":"2024-01-21T10:10:49","modified_gmt":"2024-01-21T02:10:49","slug":"angew-chem-%e9%93%9c%e7%a6%bb%e5%ad%90%e5%93%8d%e5%ba%94%e7%9a%84dnazyme","status":"publish","type":"post","link":"http:\/\/www.chemhui.com\/angew-chem-%e9%93%9c%e7%a6%bb%e5%ad%90%e5%93%8d%e5%ba%94%e7%9a%84dnazyme\/","title":{"rendered":"Angew. Chem. | \u94dc\u79bb\u5b50\u54cd\u5e94\u7684DNAzyme"},"content":{"rendered":"<p>\u53d1\u8868\u5728\u5fb7\u56fd\u5e94\u5316\u4e0a\u7684\u6587\u7ae0\uff0c\u672c\u6587\u6784\u5efa\u4e86\u4e00\u79cd\u94dc\u79bb\u5b50\u54cd\u5e94\u7684DNAzymes, \u8be5\u9176\u53ea\u5728\u94dc\u79bb\u5b50\u5b58\u5728\u7684\u6761\u4ef6\u4e0b\u624d\u5177\u6709RNA\u5207\u5272\u6d3b\u6027\u3002\u6587\u7ae0\u7684\u901a\u8baf\u4f5c\u8005\u662f\u6765\u81ea\u4e1c\u4eac\u5927\u5b66\u7684Mitsuhiko Shionoya\u6559\u6388\u3002Shionoya\u6559\u6388\u4e3b\u8981\u4ece\u4e8b\u5206\u5b50\u673a\u5668\u7684\u5408\u6210\u4e0e\u529f\u80fd\u5316\u548c\u52a8\u6001\u7eb3\u7c73\u7a7a\u95f4\u7684\u8bbe\u8ba1\u4e0e\u6784\u5efa\u7b49\u65b9\u5411\u7684\u7814\u7a76\u3002<\/p>\n<p><img decoding=\"async\" title=\"1\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20240115\/1705303219299469.png\" alt=\"1\" \/><\/p>\n<p>DNAzymes\u662f\u4e00\u79cd\u5177\u6709\u50ac\u5316\u529f\u80fd\u7684DNA\u5206\u5b50\uff0c\u53ef\u4ee5\u50ac\u5316RNA\u88c2\u89e3\u7b49\u5316\u5b66\u53cd\u5e94\u3002\u7531\u4e8e\u5176\u5e8f\u5217\u53ef\u7f16\u7a0b\u6027\u3001\u6613\u4e8e\u5408\u6210\u548c\u5316\u5b66\u7a33\u5b9a\u6027\uff0cDNAzymes\u88ab\u5e7f\u6cdb\u7528\u4e8e\u6784\u5efaDNA\u4f20\u611f\u5668\u3001\u8bca\u65ad\u5de5\u5177\u548c\u5206\u5b50\u673a\u5668\u7b49\u3002\u8fd1\u5e74\u6765\uff0c\u5916\u754c\u523a\u6fc0\u5bf9DNAzyme\u6d3b\u6027\u7684\u8c03\u8282\u8d8a\u6765\u8d8a\u53d7\u5230\u4eba\u4eec\u7684\u5173\u6ce8\uff0c\u7814\u7a76\u8005\u4eec\u5728\u523a\u6fc0\u53cd\u5e94\u578bDNAzymes\u7684\u5f00\u53d1\u4e0a\u505a\u51fa\u4e86\u8bf8\u591a\u7a81\u7834\u3002\u76ee\u524d\u53ef\u4ee5\u901a\u8fc7\u5be1\u6838\u82f7\u9178\u6742\u4ea4\u3001pH\u3001\u5c0f\u5206\u5b50\u7ed3\u5408\u7b49\u591a\u79cd\u65b9\u5f0f\u63a7\u5236DNAzymes\u7684\u6d3b\u6027\u3002\u5229\u7528\u975e\u5929\u7136\u529f\u80fd\u5355\u5143\u7684\u5316\u5b66\u4fee\u9970\u4e5f\u662f\u6784\u5efa\u5bf9\u5916\u90e8\u523a\u6fc0(\u5982\u5149\u7167\u5c04)\u6709\u53cd\u5e94\u7684DNAzymes\u7684\u4e00\u79cd\u6709\u6548\u65b9\u6cd5.<\/p>\n<p>\u672c\u6587\u4e2d\u4f5c\u8005\u5229\u7528\u975e\u5929\u7136\u78b1\u57fa\u6211\u4eec\u62a5\u544a\u4e86\u4e00\u79cd\u5408\u7406\u8bbe\u8ba1\u7684Cu<sup>2+<\/sup>\u54cd\u5e94\u578bDNAzyme\uff0c\u8be5DNAzyme\u662f\u901a\u8fc7\u5c06\u4e00\u79cd\u6700\u7a33\u5b9a\u7684\u4eba\u5de5\u91d1\u5c5e\u78b1\u57fa\u5bf9\uff0c\u5373Cu<sup>2+<\/sup>\u4ecb\u5bfc\u7684\u7fa7\u57fa\u54aa\u5511\u78b1\u57fa\u5bf9(ImC-Cu<sup>2+<\/sup>-ImC)\u63d2\u5165\u5230\u5df2\u77e5\u7684RNA\u88c2\u89e3\u578bDNAzyme\u4e2d\u3002\u8be5\u78b1\u57fa\u5bf9\u5728\u94dc\u79bb\u5b50\u5b58\u5728\u7684\u60c5\u51b5\u4e0b\u53ef\u4ee5\u53d1\u751f\u914d\u5bf9\uff0c\u800c\u5728\u6ca1\u6709\u94dc\u79bb\u5b50\u7684\u60c5\u51b5\u4e0b\u5219\u4e0d\u80fd\u53d1\u751f\u78b1\u57fa\u76f8\u4e92\u4f5c\u7528\u3002\u7531\u6b64\u6765\u5411DNAzyme\u4e2d\u5f15\u5165\u94dc\u79bb\u5b50\u54cd\u5e94\u529f\u80fd\u3002<\/p>\n<p><img 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\u6d3b\u6027\u63a5\u8fd1\u3002\u672c\u6587\u4e2d\u8bbe\u8ba1\u7684\u94dc\u79bb\u5b50\u54cd\u5e94DNAzyme\u5176\u5f00\/\u5173\u6bd4\u7387\u9ad8\u8fbe12\u500d\uff0c\u8fdc\u8fdc\u8d85\u8fc7\u4e86\u5148\u524d\u62a5\u9053\u7684\u4f7f\u7528Cu<sup>2+<\/sup>\u4ecb\u5bfc\u7684\u7f9f\u57fa\u5421\u5576\u916e\u78b1\u57fa\u5bf9\u7684DNAzyme\u3002DNAzyme\u6d3b\u6027\u53ef\u4ee5\u5728\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u901a\u8fc7Cu<sup>2+<\/sup>\u7684\u6dfb\u52a0\u3001\u53bb\u9664\u6216\u8fd8\u539f\u6765\u8fdb\u884c\u8c03\u8282\u3002<\/p>\n<p><img decoding=\"async\" title=\"9\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20240115\/1705303235108036.png\" alt=\"9\" \/><\/p>\n<p>\u7efc\u4e0a\uff0c\u4f5c\u8005\u8bbe\u8ba1\u4e86\u4e00\u79cd\u94dc\u79bb\u5b50\u54cd\u5e94\u7684DNAzyme\uff0c\u53ef\u4ee5\u5728\u94dc\u79bb\u5b50\u5b58\u5728\u7684\u6761\u4ef6\u4e0b\u8868\u73b0\u51fa\u6d3b\u6027\uff0c\u4e00\u65e6\u9664\u53bb\u94dc\u79bb\u5b50\uff0c\u4f8b\u5982\u52a0\u5165\u94dc\u79bb\u5b50\u7ed3\u5408\u4e09\u80bd(GHK)\u53c8\u53ef\u4ee5\u8fc5\u901f\u5931\u6d3b\u3002\u8fd9\u79cd\u65b9\u6cd5\u5c06\u4fc3\u8fdb\u5177\u6709\u5feb\u901f\u5f00\u5173\u80fd\u529b\u7684DNA\u7cfb\u7edf\u7684\u53d1\u5c55\u3002<\/p>\n<p>\u6587\u7ae0\u4f5c\u8005\uff1aGuo ZH<\/p>\n<p>\u539f\u6587\u94fe\u63a5\uff1a<\/p>\n<p>https:\/\/www.onlinelibrary.wiley.com\/doi\/full\/10.1002\/anie.202009579<\/p>\n<p>\u6587\u7ae0\u5f15\u7528\uff1aDOI\uff1a10.1002\/anie.202009579<\/p>\n<p>\u8d23\u4efb\u7f16\u8f91\uff1aLBW<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u53d1\u8868\u5728\u5fb7\u56fd\u5e94\u5316\u4e0a\u7684\u6587\u7ae0\uff0c\u672c\u6587\u6784\u5efa\u4e86\u4e00\u79cd\u94dc\u79bb\u5b50\u54cd\u5e94\u7684DNAzymes, \u8be5\u9176\u53ea\u5728\u94dc\u79bb\u5b50\u5b58\u5728\u7684\u6761\u4ef6\u4e0b\u624d\u5177\u6709RNA\u5207 [&hellip;]<\/p>\n","protected":false},"author":326,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[],"class_list":["post-50740","post","type-post","status-publish","format-standard","hentry","category-tuijianyuedu"],"_links":{"self":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/50740","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/users\/326"}],"replies":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/comments?post=50740"}],"version-history":[{"count":1,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/50740\/revisions"}],"predecessor-version":[{"id":50741,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/50740\/revisions\/50741"}],"wp:attachment":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/media?parent=50740"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/categories?post=50740"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/tags?post=50740"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}