{"id":50658,"date":"2024-01-25T08:03:29","date_gmt":"2024-01-25T00:03:29","guid":{"rendered":"https:\/\/www.chemhui.com\/?p=50658"},"modified":"2024-01-08T10:03:49","modified_gmt":"2024-01-08T02:03:49","slug":"%e3%80%90j-am-chem-soc-%e3%80%91%e5%88%a9%e7%94%a8%e9%bb%84%e7%b4%a0%e8%bd%ac%e7%a7%bb%e9%85%b6%e5%b0%86%e5%8f%af%e5%88%86%e7%a6%bb%e9%bb%84%e7%b4%a0%e8%9b%8b%e7%99%bd%e8%bd%ac","status":"publish","type":"post","link":"http:\/\/www.chemhui.com\/%e3%80%90j-am-chem-soc-%e3%80%91%e5%88%a9%e7%94%a8%e9%bb%84%e7%b4%a0%e8%bd%ac%e7%a7%bb%e9%85%b6%e5%b0%86%e5%8f%af%e5%88%86%e7%a6%bb%e9%bb%84%e7%b4%a0%e8%9b%8b%e7%99%bd%e8%bd%ac\/","title":{"rendered":"\u3010J. Am. Chem. Soc.\u3011\u5229\u7528\u9ec4\u7d20\u8f6c\u79fb\u9176\u5c06\u201c\u53ef\u5206\u79bb\u201d\u9ec4\u7d20\u86cb\u767d\u8f6c\u53d8\u4e3a\u5171\u4ef7\u9ec4\u7d20\u86cb\u767d"},"content":{"rendered":"<p>\u9ec4\u7d20\u86cb\u767d\u662f\u5229\u7528\u9ec4\u7d20\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178\uff08FAD\uff09\u6216\u9ec4\u7d20\u5355\u6838\u82f7\u9178\uff08FMN\uff09\u4f5c\u4e3a\u8f85\u52a9\u56e0\u5b50\u53d1\u6325\u5176\u529f\u80fd\u7684\u86cb\u767d\u8d28\u3002\u5927\u591a\u6570\u9ec4\u7d20\u86cb\u767d\u542b\u6709FAD\u6216FMN\u4f5c\u4e3a\u53ef\u89e3\u79bb\u7684\u8f85\u56e0\u5b50\uff0c\u53ea\u6709\u5c11\u6570\u7684\u9ec4\u7d20\u86cb\u767d\u542b\u6709\u5171\u4ef7\u8fde\u63a5\u7684\u9ec4\u7d20\u8f85\u56e0\u5b50\uff08\u4e3b\u8981\u4e3aFAD\uff09\u3002\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u5728\u5929\u7136\u9ec4\u7d20\u86cb\u767d\u4e2d\u5df2\u7ecf\u9274\u5b9a\u51fa\u4e5d\u79cd\u4e0d\u540c\u7c7b\u578b\u7684\u5171\u4ef7\u9ec4\u7d20\u86cb\u767d\u8fde\u63a5\u3002\u7814\u7a76\u8868\u660e\uff0c\u9ec4\u7d20\u548c\u5bbf\u4e3b\u86cb\u767d\u4e4b\u95f4\u7684\u5171\u4ef7\u952e\u53ef\u4ee5\u5f62\u6210\u66f4\u7a33\u5b9a\u7684\u86cb\u767d\u8d28\u7ed3\u6784\uff0c\u589e\u52a0\u9176\u6d3b\u6027\uff0c\u8c03\u8282\u9176\u7684\u6c27\u5316\u8fd8\u539f\u7279\u6027\uff0c\u9632\u6b62\u8f85\u56e0\u5b50\u89e3\u79bb\uff0c\u5e76\u4fc3\u8fdb\u7535\u5b50\u8f6c\u79fb\u3002\u5927\u591a\u6570\u9ec4\u7d20\u86cb\u767d\u8fde\u63a5\u6d89\u53caFMN\u6216FAD\u7684\u5f02\u6076\u5511\u55ea\u73af\u7cfb\u7edf\u7684\u82c4\u57fa\u90e8\u5206\u7684\u6c27\u5316\u8fd8\u539f\u6d3b\u6027\u4e4b\u95f4\u7684\u5171\u4ef7\u952e\u3002<\/p>\n<p>\u57fa\u4e8e\u524d\u671f\u7814\u7a76\u7ed3\u679c\uff0cUniversity of Groningen\u7684Marco W. Fraaije\u8bfe\u9898\u7ec4\u63d0\u51fa\u4e86\u4e00\u79cd\u5728\u4f53\u5185\u9ec4\u7d20\u8f85\u56e0\u5b50\u4e0e\u5176\u5bbf\u4e3b\u86cb\u767d\u4e4b\u95f4\u5efa\u7acb\u5171\u4ef7\u952e\u7684\u65b0\u65b9\u6cd5\u3002\u8be5\u65b9\u6cd5\u662f\u901a\u8fc7\u4f7f\u7528\u9ec4\u7d20\u8f6c\u79fb\u9176\u5728\u9776\u86cb\u767d\u4e2d\u5bf9\u9ec4\u7d20\u5316\u57fa\u5e8f\u8fdb\u884c\u5de5\u7a0b\u5316\u6539\u9020\uff0c\u7ed3\u679c\u8bc1\u660e\u201c\u53ef\u89e3\u79bb\u201d\u7684\u9ec4\u7d20\u86cb\u767d\u53ef\u4ee5\u8f6c\u5316\u4e3a\u5171\u4ef7\u9ec4\u7d20\u86cb\u767d\u3002\u901a\u8fc7\u8fd9\u79cd\u65b9\u6cd5\uff0c\u8be5\u7814\u7a76\u5c06\u56db\u79cd\u4e0d\u540c\u7684\u542bFMN\u7684\u86cb\u767d\u6539\u9020\u6210\u5171\u4ef7\u9ec4\u7d20\u9170\u5316\u86cb\u767d\uff1a\u5149\u6c27\u7535\u538b\u7ed3\u6784\u57df\u86cb\u767d\u8d28\u3001\u8ff7\u4f60\u5355\u7ebf\u6001\u6c27\u53d1\u751f\u5668\u3001\u785d\u57fa\u8fd8\u539f\u9176\u548c\u8001\u9ec4\u9176\u5bb6\u65cf\u7684\u70ef\u8fd8\u539f\u9176\u3002<\/p>\n<p><img decoding=\"async\" title=\"1\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20240102\/1704164333694896.png\" alt=\"1\" \/><\/p>\n<p>\u56fe\u7247\u6765\u6e90\uff1aJ. Am. Chem. Soc.<\/p>\n<p>\u4f18\u5316\u9ec4\u7d20\u9170\u5316\u57fa\u5e8f\u548c\u8868\u8fbe\u6761\u4ef6\u4f7f\u5f97\u6240\u6709\u56db\u79cd\u9ec4\u7d20\u86cb\u767d\u8f6c\u53d8\u4e3a\u5171\u4ef7\u9ec4\u7d20\u9170\u5316\u3002\u5de5\u7a0b\u5316\u6539\u9020\u5171\u4ef7\u9ec4\u7d20\u86cb\u767d\u4fdd\u7559\u4e86\u5176\u50ac\u5316\u529f\u80fd\uff0c\u540c\u65f6\u8fd8\u8868\u73b0\u51fa\u6539\u8fdb\u7684\u6027\u80fd\uff0c\u5982\u66f4\u9ad8\u7684\u70ed\u7a33\u5b9a\u6027\u6216\u50ac\u5316\u6027\u80fd\u3002<\/p>\n<p><img decoding=\"async\" title=\"2\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20240102\/1704164341531070.png\" alt=\"2\" \/><\/p>\n<p>\u56fe\u7247\u6765\u6e90\uff1aJ. Am. Chem. Soc.<\/p>\n<p>\u6676\u4f53\u7ed3\u6784\u7814\u7a76\u7ed3\u679c\u663e\u793a\u4e86\u5de5\u7a0b\u5316\u6539\u9020\u86cb\u767d\u4e2d\u7684\u6240\u8bbe\u8ba1\u7684\u78f7\u9178\u82cf\u6c28\u9178\u952e\u3002\u9776\u5411\u9ec4\u7d20\u86cb\u767d\u5728\u6298\u53e0\u548c\u529f\u80fd\u4e0a\u4e0d\u540c\uff0c\u8868\u660e\u8fd9\u79cd\u5f15\u5165\u5171\u4ef7\u9ec4\u7d20\u86cb\u767d\u952e\u7684\u65b9\u6cd5\u662f\u4e00\u79cd\u5f3a\u5927\u7684\u65b0\u65b9\u6cd5\uff0c\u53ef\u4ee5\u4ea7\u751f\u4e0d\u4f1a\u5931\u53bb\u8f85\u56e0\u5b50\u7684\u9ec4\u7d20\u86cb\u767d\uff0c\u4ece\u800c\u63d0\u9ad8\u5176\u6027\u80fd\u3002<\/p>\n<p><img decoding=\"async\" title=\"9\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20240102\/1704164353430639.png\" alt=\"9\" \/><\/p>\n<p>\u56fe\u7247\u6765\u6e90\uff1aJ. Am. Chem. Soc.<\/p>\n<p>\u539f\u6587\u6807\u9898\uff1aFixing Flavins: Hijacking a Flavin Transferase for Equipping Flavoproteins with a Covalent Flavin Cofactor<\/p>\n<p>https:\/\/doi.org\/10.1021\/jacs.3c12009<\/p>\n<p>\u539f\u6587\u4f5c\u8005\uff1aYapei Tong, Saniye G. Kaya, Sara Russo, Henriette J. Rozeboom, Hein J. Wijma, and Marco W. Fraaije*<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u9ec4\u7d20\u86cb\u767d\u662f\u5229\u7528\u9ec4\u7d20\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178\uff08FAD\uff09\u6216\u9ec4\u7d20\u5355\u6838\u82f7\u9178\uff08FMN\uff09\u4f5c\u4e3a\u8f85\u52a9\u56e0\u5b50\u53d1\u6325\u5176\u529f\u80fd\u7684\u86cb\u767d\u8d28\u3002\u5927\u591a\u6570\u9ec4\u7d20\u86cb [&hellip;]<\/p>\n","protected":false},"author":326,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[],"class_list":["post-50658","post","type-post","status-publish","format-standard","hentry","category-tuijianyuedu"],"_links":{"self":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/50658","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/users\/326"}],"replies":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/comments?post=50658"}],"version-history":[{"count":1,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/50658\/revisions"}],"predecessor-version":[{"id":50659,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/50658\/revisions\/50659"}],"wp:attachment":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/media?parent=50658"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/categories?post=50658"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/tags?post=50658"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}