{"id":49556,"date":"2023-12-20T08:33:04","date_gmt":"2023-12-20T00:33:04","guid":{"rendered":"https:\/\/www.chemhui.com\/?p=49556"},"modified":"2023-12-03T14:35:00","modified_gmt":"2023-12-03T06:35:00","slug":"nat-chem-biol-%e9%80%9a%e8%bf%87%e5%90%88%e6%88%90%e7%9a%84crispr-cas6%e6%a0%b8%e9%85%b8%e5%86%85%e5%88%87%e9%85%b6%e5%8a%a8%e6%80%81%e8%b0%83%e8%8a%82%e9%85%b6%e6%b4%bb%e6%80%a7","status":"publish","type":"post","link":"http:\/\/www.chemhui.com\/nat-chem-biol-%e9%80%9a%e8%bf%87%e5%90%88%e6%88%90%e7%9a%84crispr-cas6%e6%a0%b8%e9%85%b8%e5%86%85%e5%88%87%e9%85%b6%e5%8a%a8%e6%80%81%e8%b0%83%e8%8a%82%e9%85%b6%e6%b4%bb%e6%80%a7\/","title":{"rendered":"Nat. Chem. Biol. | \u901a\u8fc7\u5408\u6210\u7684CRISPR\u2013Cas6\u6838\u9178\u5185\u5207\u9176\u52a8\u6001\u8c03\u8282\u9176\u6d3b\u6027"},"content":{"rendered":"<section>\u5206\u4eab\u4e00\u7bc7\u53d1\u8868\u5728nature chemical biology\u4e0a\u9762\u7684\u6587\u7ae0\uff0c\u6587\u7ae0\u9898\u76ee\u4e3a\u201cDynamic modulation of enzyme activity by synthetic CRISPR\u2013Cas6endonucleases\u201d\uff0c\u672c\u6587\u7684\u901a\u8baf\u4f5c\u8005\u4e3a\u7279\u62c9\u534e\u5927\u5b66\u5316\u5b66\u4e0e\u751f\u7269\u5206\u5b50\u5de5\u7a0b\u7cfb\u7684Wilfred Chen\u6559\u6388\uff0c\u4ed6\u4eec\u8bfe\u9898\u7ec4\u4e3b\u8981\u7814\u7a76\u65b9\u5411\u4e3a\u5408\u6210\u751f\u7269\u5b66\u3001\u86cb\u767d\u8d28\u5de5\u7a0b\u3001\u57fa\u56e0\u548c\u836f\u7269\u9012\u9001\u4ee5\u53ca\u764c\u75c7\u6cbb\u7597\u3002<\/section>\n<p>&nbsp;<\/p>\n<section><\/section>\n<p>&nbsp;<\/p>\n<p><img decoding=\"async\" title=\"1\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20231127\/1701053522570564.png\" alt=\"1\" 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src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20231127\/1701053530132701.png\" alt=\"2\" \/><\/p>\n<p>&nbsp;<\/p>\n<section>\u8be5\u7b56\u7565\u662f\u5148\u5c06\u8981\u8c03\u8282\u7684\u9176\u4e0eCas\u5bb6\u65cf\u7684\u86cb\u767d\u878d\u5408\u5728\u4e00\u8d77\uff0c\u7136\u540e\u5229\u7528\u4e00\u4e2a\u652f\u67b6RNA\u5c06\u8fd9\u4e24\u4e2aCas6-\u9176\u878d\u5408\u7269\u62db\u52df\u5728\u5b83\u4eec\u5404\u81ea\u7684\u53d1\u5361\u4e0a\uff0c\u7b2c\u4e00\u4e2aCas6\u86cb\u767d\u4f1a\u57283\u2019 \u7aef\u5207\u65adRNA\u652f\u67b6\uff0c\u4e4b\u540e\u4f1a\u4ea7\u751f\u4e24\u4e2a\u4e0d\u540c\u7684\u9176-RNA\u590d\u5408\u7269\uff0c\u7531\u4e8e\u8fd9\u4e24\u4e2aRNA\u94fe\u57285\u2019 \u7aef\u662f\u4e92\u8865\u7684\uff0c\u6240\u4ee5\u4e24\u6761RNA\u94fe\u5c31\u4f1a\u6742\u4ea4\uff0c\u4f7f\u4e24\u4e2a\u9176\u9760\u8fd1\uff0c\u5f62\u6210\u9176\u590d\u5408\u7269\uff0c\u540c\u65f6\u5728\u5728\u6742\u4ea4\u7684RNA\u94fe5\u2019 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decoding=\"async\" title=\"8\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20231127\/1701053555614726.png\" alt=\"8\" \/><\/p>\n<p>&nbsp;<\/p>\n<section><strong>\u603b\u800c\u8a00\u4e4b\uff0c\u672c\u6587\u4f5c\u8005\u5c06RNA\u652f\u67b6\u548cCRISPR-Cas6\u9176\u7ec4\u88c5\u5728\u4e00\u8d77\uff0c\u5229\u7528TMSD\u7b56\u7565\u5b9e\u73b0\u4e86\u9176\u6d3b\u6027\u7684\u52a8\u6001\u8c03\u8282\u3002<\/strong><\/section>\n<p>&nbsp;<\/p>\n<p>\u672c\u6587\u4f5c\u8005\uff1aLZ<\/p>\n<p>\u8d23\u4efb\u7f16\u8f91\uff1aLDY<\/p>\n<p>\u539f\u6587\u94fe\u63a5\uff1ahttps:\/\/www.nature.com\/articles\/s41589-022-01005-7<\/p>\n<p>\u6587\u7ae0\u5f15\u7528\uff1aDOI\uff1a10.1038\/s41589-022-01005-7<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5206\u4eab\u4e00\u7bc7\u53d1\u8868\u5728nature chemical biology\u4e0a\u9762\u7684\u6587\u7ae0\uff0c\u6587\u7ae0\u9898\u76ee\u4e3a\u201cDynamic modul 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