{"id":49524,"date":"2023-12-15T08:58:31","date_gmt":"2023-12-15T00:58:31","guid":{"rendered":"https:\/\/www.chemhui.com\/?p=49524"},"modified":"2023-11-28T09:58:59","modified_gmt":"2023-11-28T01:58:59","slug":"acs-cent-sci-%e6%8b%89%e4%bc%b8%e5%a4%9a%e8%82%bd%e7%94%9f%e6%88%90%e5%b0%8f%e5%88%86%e5%ad%90%ce%b2-%e6%8a%98%e5%8f%a0%e8%82%a1%e6%a8%a1%e6%8b%9f%e7%89%a9","status":"publish","type":"post","link":"http:\/\/www.chemhui.com\/acs-cent-sci-%e6%8b%89%e4%bc%b8%e5%a4%9a%e8%82%bd%e7%94%9f%e6%88%90%e5%b0%8f%e5%88%86%e5%ad%90%ce%b2-%e6%8a%98%e5%8f%a0%e8%82%a1%e6%a8%a1%e6%8b%9f%e7%89%a9\/","title":{"rendered":"ACS Cent. Sci. | \u62c9\u4f38\u591a\u80bd\u751f\u6210\u5c0f\u5206\u5b50\u03b2-\u6298\u53e0\u80a1\u6a21\u62df\u7269"},"content":{"rendered":"<section>\u4e3a\u5927\u5bb6\u5206\u4eab\u4e00\u7bc7\u53d1\u8868\u5728ACS Central Science\u4e0a\u7684\u6587\u7ae0Stretching Peptides to Generate Small Molecule \u03b2-Strand Mimics\uff0c\u901a\u8baf\u4f5c\u8005\u662f\u6765\u81eaScripps\u7814\u7a76\u6240\u7684Philip E. Dawson\u6559\u6388\uff0c\u4ed6\u7684\u7814\u7a76\u65b9\u5411\u5305\u62ec\u86cb\u767d\u548c\u591a\u80bd\u7684\u5316\u5b66\u5408\u6210\u3001\u975e\u5929\u7136\u6c28\u57fa\u9178\u5f15\u5165\u7b49\u3002<\/section>\n<p>&nbsp;<\/p>\n<section><img decoding=\"async\" title=\"1\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20231122\/1700622097775083.png\" alt=\"1\" 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decoding=\"async\" title=\"2\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20231122\/1700622105667351.png\" alt=\"2\" \/><\/section>\n<section><\/section>\n<section>\u968f\u540e\uff0c\u4f5c\u8005\u901a\u8fc7DFT\u8ba1\u7b97\u548cNMR\u5b9e\u9a8c\u5bf9\u80bd\u8fdb\u884c\u4e86\u7ed3\u6784\u8868\u5f81\uff0c\u53d1\u73b0\u53cc\u7094\u952e\u7684\u786e\u5b58\u5728\u975e\u7ebf\u6027\u952e\u89d2\u626d\u66f2\uff0c\u4e14\u626d\u66f2\u7a0b\u5ea6\u4e0e\u5927\u73af\u7684\u5c3a\u5bf8\u5bc6\u5207\u76f8\u5173\u3002\u53cc\u7094\u952e\u5f62\u6210\u6b8b\u57fa\u7684\u7acb\u4f53\u5316\u5b66\u4e5f\u5bf9\u4ea7\u7269\u6784\u8c61\u5177\u6709\u4e00\u5b9a\u5f71\u54cd\uff0c\u4f46\u8ba1\u7b97\u548c\u5b9e\u9a8c\u7ed3\u679c\u90fd\u8bc1\u660e\u53cc\u7094\u80bd\u5177\u6709\u663e\u8457\u7684\u03b2\u5ef6\u4f38\u6784\u8c61\u3002<\/section>\n<section><img decoding=\"async\" title=\"3\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20231122\/1700622112220964.png\" alt=\"3\" \/><\/section>\n<section><\/section>\n<section>\u4e3a\u5c55\u793a\u8be5\u7b56\u7565\u7684\u5177\u4f53\u5e94\u7528\uff0c\u4f5c\u8005\u9009\u62e9\u4e86\u7ec6\u83cc1\u578b\u4fe1\u53f7\u80bd\u9176(SPase)\u4f5c\u4e3a\u9776\u70b9\uff0c\u8be5\u9176\u88ab\u53d1\u73b0\u5b58\u5728\u4e00\u79cd\u5929\u7136\u4ea7\u7269\u6291\u5236\u5242Arylomycins\uff0c\u8fd9\u79cd\u80bd\u57fa\u6297\u751f\u7d20\u88ab\u4e00\u4e2a\u7279\u6b8a\u7684\u8054\u82b3\u57fa\u5927\u73af\u6865\u63a5\uff0c\u8feb\u4f7f\u5176\u91c7\u53d6\u5ef6\u5c55\u7684\u03b2\u6784\u8c61\u3002\u4f5c\u8005\u5bf9\u6676\u4f53\u7ed3\u6784\u7684\u89c2\u5bdf\u663e\u793a\uff0c\u8054\u82b3\u57fa\u5927\u73af\u4f4d\u4e8e\u6eb6\u5242\u66b4\u9732\u533a\u57df\uff0c\u5bf9\u76f8\u4e92\u4f5c\u7528\u6ca1\u6709\u663e\u8457\u8d21\u732e\u3002\u56e0\u6b64\u4f5c\u8005\u4f7f\u7528\u53cc\u7094\u5927\u73af\u6539\u9020\u4e86Arylomycins\uff0c\u79f0\u4e3a\u201cAlkynomycins\u201d\uff0c\u5e76\u8bc1\u660e\u4ec5\u4f7f\u7528\u53cc\u7094\u952e\u8d4b\u4e88\u7684\u9aa8\u67b6\u6784\u8c61\u5c31\u8db3\u4ee5\u6a21\u4effArylomycins\u7684\u529f\u80fd\u6d3b\u6027\uff0c\u4e14\u5177\u6709\u8fdb\u4e00\u6b65\u4f18\u5316\u5f97\u5230\u65b0\u578b\u6297\u751f\u7d20\u7684\u6f5c\u529b\u3002<\/section>\n<section><img decoding=\"async\" title=\"8\" src=\"https:\/\/9794.seohost.cn\/storage\/9794\/article\/20231122\/1700622122270746.png\" alt=\"8\" \/><\/section>\n<section><\/section>\n<section><strong>\u603b\u4e4b\uff0c\u4f5c\u8005\u62a5\u5bfc\u4e86\u4e00\u79cd\u901a\u8fc7Glaser\u53cc\u7094\u5076\u8054\u5728\u6811\u8102\u4e0a\u5feb\u901f\u5408\u6210\u6784\u8c61\u7ea6\u675f\u03b2-\u5927\u73af\u80bd\u7684\u7b56\u7565\uff0c\u5e76\u8bc1\u660e\u8be5\u7b56\u7565\u5728\u86cb\u767d\u9176\u6291\u5236\u5242\u8bbe\u8ba1\u4e2d\u5177\u6709\u5f88\u597d\u7684\u5b9e\u7528\u6027\u3002<\/strong><\/section>\n<section><\/section>\n<p>&nbsp;<\/p>\n<p>\u672c\u6587\u4f5c\u8005\uff1aWFZ<\/p>\n<p>\u8d23\u4efb\u7f16\u8f91\uff1aTZY<\/p>\n<p>\u539f\u6587\u94fe\u63a5\uff1ahttps:\/\/pubs.acs.org\/doi\/10.1021\/acscentsci.2c01462<\/p>\n<p>\u6587\u7ae0\u5f15\u7528\uff1aDOI\uff1a10.1021\/acscentsci.2c01462<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e3a\u5927\u5bb6\u5206\u4eab\u4e00\u7bc7\u53d1\u8868\u5728ACS Central Science\u4e0a\u7684\u6587\u7ae0Stretching Peptides to [&hellip;]<\/p>\n","protected":false},"author":326,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[],"class_list":["post-49524","post","type-post","status-publish","format-standard","hentry","category-tuijianyuedu"],"_links":{"self":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/49524","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/users\/326"}],"replies":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/comments?post=49524"}],"version-history":[{"count":1,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/49524\/revisions"}],"predecessor-version":[{"id":49525,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/49524\/revisions\/49525"}],"wp:attachment":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/media?parent=49524"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/categories?post=49524"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/tags?post=49524"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}