{"id":49219,"date":"2023-10-30T08:57:18","date_gmt":"2023-10-30T00:57:18","guid":{"rendered":"https:\/\/www.chemhui.com\/?p=49219"},"modified":"2023-10-13T09:57:41","modified_gmt":"2023-10-13T01:57:41","slug":"chem-sci-%e5%88%a9%e7%94%a8%e8%b6%85%e5%88%86%e5%ad%90%e6%9d%90%e6%96%99%e5%8f%91%e7%8e%b0%e7%a3%b7%e9%85%b8%e5%8c%96%e9%85%aa%e6%b0%a8%e9%85%b8%e7%9a%84%e7%bb%93%e5%90%88%e8%82%bd","status":"publish","type":"post","link":"http:\/\/www.chemhui.com\/chem-sci-%e5%88%a9%e7%94%a8%e8%b6%85%e5%88%86%e5%ad%90%e6%9d%90%e6%96%99%e5%8f%91%e7%8e%b0%e7%a3%b7%e9%85%b8%e5%8c%96%e9%85%aa%e6%b0%a8%e9%85%b8%e7%9a%84%e7%bb%93%e5%90%88%e8%82%bd\/","title":{"rendered":"Chem. Sci. | \u5229\u7528\u8d85\u5206\u5b50\u6750\u6599\u53d1\u73b0\u78f7\u9178\u5316\u916a\u6c28\u9178\u7684\u7ed3\u5408\u80bd"},"content":{"rendered":"

\u5206\u4eab\u4e00\u7bc7\u53d1\u8868\u5728chemical Science\u4e0a\u7684\u6587\u7ae0\uff0c\u9898\u76ee\u4e3a\u201cDiscovery of phosphotyrosine-binding oligopeptides with supramolecular target selectivity\u201d\u3002\u6587\u7ae0\u7684\u4e09\u4f4d\u901a\u8baf\u4f5c\u8005\u5206\u522b\u662f\u6765\u81ea\u7ebd\u7ea6\u5e02\u7acb\u5927\u5b66\u7684Rein V. Ulijn\u6559\u6388\u3001\u6765\u81ea\u91cc\u65af\u672c\u5927\u5b66\u7684A. Cec\u0131lia A. Roque\u6559\u6388\u4ee5\u53caAna Pina\u7814\u7a76\u5458\u3002Rein V. Ulijn\u6559\u6388\u7684\u4e3b\u8981\u7814\u7a76\u65b9\u5411\u662f\u5c0f\u80bd\u7eb3\u7c73\u6750\u6599\u7684\u8bbe\u8ba1\uff0cA. Cec\u0131lia A. Roque\u6559\u6388\u7684\u4e3b\u8981\u7814\u7a76\u65b9\u5411\u662f\u751f\u7269\u533b\u836f\u76f8\u5173\u4eb2\u548c\u53d7\u4f53\u7684\u5f00\u53d1\uff0cAna Pina\u7684\u7814\u7a76\u5174\u8da3\u662f\u591a\u80bd\u548c\u86cb\u767d\u76f8\u5173\u7684\u7eb3\u7c73\u6280\u672f\u3002<\/p>\n

\"1\"<\/p>\n

 <\/p>\n

\u5be1\u80bd\u4f5c\u4e3a\u4e00\u79cd\u91cd\u8981\u7684\u751f\u7269\u5c0f\u5206\u5b50\uff0c\u5728\u5206\u5b50\u8bc6\u522b\u3001\u81ea\u7ec4\u88c5\u4ee5\u53ca\u50ac\u5316\u8c03\u63a7\u7b49\u65b9\u9762\u90fd\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\uff0c\u53d1\u5c55\u529f\u80fd\u80bd\u4f5c\u4e3a\u86cb\u767d\u8d28\u529f\u80fd\u6807\u7b7e\u4e5f\u9010\u6e10\u5f15\u8d77\u4e86\u5927\u5bb6\u7684\u7814\u7a76\u5174\u8da3\u3002\u5bf9\u4e8e\u529f\u80fd\u80bd\u7684\u53d1\u73b0\u4e3b\u8981\u662f\u901a\u8fc7\u8ba1\u7b97\u673a\u7406\u6027\u8bbe\u8ba1\uff1b\u7ec4\u5408\u7b5b\u9009\uff1b\u52a8\u6001\u80bd\u6bb5\u5e93\uff1b\u566c\u83cc\u4f53\u5c55\u793a\u7b49\u65b9\u6cd5\u6765\u5b9e\u73b0\u7684\u3002\u8fc7\u91cf\u7684\u916a\u6c28\u9178\u78f7\u9178\u5316\u5e38\u89c1\u4e8e\u4ee3\u8c22\u4ee5\u53ca\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7b49\uff0c\u53d1\u5c55\u53ef\u4ee5\u8bc6\u522b\u916a\u6c28\u9178\u78f7\u9178\u5316\u7684\u6750\u6599\u5bf9\u4e8e\u76f8\u5173\u75be\u75c5\u7684\u8bca\u7597\u5177\u6709\u975e\u5e38\u91cd\u8981\u7684\u610f\u4e49\u3002\u672c\u7814\u7a76\u4e2d\uff0c\u4f5c\u8005\u8bbe\u8ba1\u4e86\u78f7\u9178\u5316\u916a\u6c28\u9178\u7684\u8d85\u5206\u5b50\u6750\u6599\uff0c\u7ed3\u5408\u566c\u83cc\u4f53\u5c55\u793a\u7684\u65b9\u6cd5\u5bf9\u78f7\u9178\u5316\u916a\u6c28\u9178\u7684\u7ed3\u5408\u80bd\u8fdb\u884c\u4e86\u9274\u5b9a\u3002\u4f5c\u8005\u4f7f\u7528\u82b3\u9999\u57fa\u56e2\u5e2e\u52a9\u751f\u7269\u5206\u5b50\u81ea\u7ec4\u88c5\u5f62\u6210\u8d85\u5206\u5b50\u6750\u6599\uff0c\u6b64\u5904\u4e3a\u82b4\u7532\u6c27\u7fb0\u57fa-\u82ef\u4e19\u6c28\u9178-\u916a\u6c28\u9178-\u78f7\u9178\u916f(Fmoc-FpY)\uff0c\u566c\u83cc\u4f53\u5c55\u793a\u91c7\u7528\u7684\u5219\u662f\u4e00\u4e2a\u5546\u54c1\u5316\u768412\u80bd\u7684 M13 \u566c\u83cc\u4f53\u5e93\u3002<\/section>\n

 <\/p>\n

\"2\"<\/p>\n

 <\/p>\n

\u4f5c\u8005\u9996\u5148\u8bc4\u4ef7\u4e86\u8be5\u8d85\u5206\u5b50\u6750\u6599\u5bf9\u4e8e\u566c\u83cc\u4f53\u5e93\u4e2d\u80bd\u6bb5\u7684\u7ed3\u5408\u80fd\u529b\uff0c\u901a\u8fc7\u900f\u5c04\u7535\u955c\u68c0\u6d4b\u53d1\u73b0\u8d85\u5206\u5b50\u53ef\u4ee5\u548c\u90e8\u5206\u80bd\u6bb5\u6709\u6548\u7ed3\u5408\uff0c\u5bf9\u4e8e\u5bf9\u7167\u7684M13\u5219\u6ca1\u6709\u7ed3\u5408\uff0c\u8bf4\u660e\u8be5\u8d85\u5206\u5b50\u662f\u5177\u6709\u660e\u663e\u9009\u62e9\u6027\u7684\u3002\u968f\u540e\u4f5c\u8005\u901a\u8fc7\u4e09\u8f6e\u6269\u589e\u7b5b\u9009\u5230\u4e8633\u4e2a\u566c\u83cc\u4f53\u7684\u9633\u6027\u514b\u9686\uff0c\u901a\u8fc7\u6d4b\u5e8f\u53d1\u73b0\u8fd933\u4e2a\u514b\u9686\u5bf9\u5e94\u4e8614\u6761\u80bd\u6bb5\u3002\u4f5c\u8005\u5bf9\u8fd914\u6761\u80bd\u6bb5\u7684\u5e8f\u5217\u7279\u5f81\u8fdb\u884c\u5206\u6790\uff0c\u5e0c\u671b\u53ef\u4ee5\u83b7\u5f97\u78f7\u9178\u5316\u916a\u6c28\u9178\u7ed3\u5408\u80bd\u7684\u57fa\u5e8f\u3002<\/section>\n

 <\/p>\n

\"3\"<\/p>\n

 <\/p>\n

\u8fd914\u6761\u80bd\u6bb5\u4e2d\uff0c\u812f\u6c28\u9178\u51fa\u73b0\u7684\u9891\u7387\u6bd4\u8f83\u9ad8\uff0c\u4e14\u5927\u591a\u6570\u90fd\u6709\u78b1\u6027\u6c28\u57fa\u9178\uff0c\u9664\u6b64\u4e4b\u5916\uff0c\u82b3\u9999\u65cf\u6c28\u57fa\u9178\u51fa\u73b0\u7684\u9891\u7387\u4e5f\u662f\u6bd4\u8f83\u9ad8\u7684\u3002\u572814\u6761\u80bd\u6bb5\u4e2dP3\uff0cP7\u548cP29\u662f\u4eb2\u548c\u529b\u6700\u9ad8\u7684\uff0c\u4f5c\u8005\u5408\u6210\u4e86\u8fd9\u4e09\u6761\u591a\u80bd\u5e76\u5728\u6eb6\u6db2\u4e2d\u9a8c\u8bc1\u4e86\u591a\u80bd\u4e0e\u8d85\u5206\u5b50\u4e4b\u95f4\u7684\u4eb2\u548c\u529b\uff0c\u5176\u4e2dP7\u7684\u4eb2\u548c\u529b\u6700\u5f3a\uff08KD =74\u00b13 \u03bcM\uff09\u3002P7 \u80bd\u6bb5\u5177\u6709\u03b2\u53d1\u5939\u7ed3\u6784\uff0c\u812f\u6c28\u9178\u4ee5\u53ca\u5176N\u7aef\u7684KVYF\u5e8f\u5217\u5bf9\u4e8e\u7ed3\u6784\u7a33\u5b9a\u662f\u6bd4\u8f83\u91cd\u8981\u7684\uff0c\u901a\u8fc7\u70b9\u7a81\u53d8\u5b9e\u9a8c\u4f5c\u8005\u4e5f\u8bc1\u660e\u4e86N\u7aefKVYF\u5bf9\u4e8e\u7ed3\u6784\u7a33\u5b9a\u7684\u91cd\u8981\u6027\u3002\u968f\u540e\u4f5c\u8005\u901a\u8fc7\u78f7\u9178\u6839\u5e95\u7269\u7684\u52a8\u529b\u5b66\u5b9e\u9a8c\u8bc1\u660eP7\u5177\u6709\u8f83\u9ad8\u7684\u78f7\u9178\u9176\u6d3b\u6027\u3002P7\u80fd\u591f\u4e0e\u8d85\u5206\u5b50\u7ed3\u5408\uff0c\u5177\u6709\u9002\u5f53\u7684\u50ac\u5316\u6d3b\u6027\u5e76\u8868\u73b0\u51fa\u6d53\u5ea6\u7684\u4f9d\u8d56\u6027\uff0c\u56e0\u6b64\u4f5c\u8005\u63d0\u51faP7\u53ef\u4ee5\u4f5c\u4e3a\u916a\u6c28\u9178\u78f7\u9178\u5316\u5931\u8c03\u5bfc\u81f4\u75be\u75c5\u7684\u6f5c\u5728\u8bca\u7597\u5de5\u5177\uff0c\u540c\u65f6\u5176\u672c\u8eab\u5206\u5b50\u91cf\u8f83\u5c0f\uff0c\u7406\u8bba\u4e0a\u50ac\u5316\u6d3b\u6027\u4f1a\u6bd4\u86cb\u767d\u66f4\u52a0\u7a33\u5b9a\u3002<\/section>\n

 <\/p>\n

\"8\"<\/p>\n

 <\/p>\n

\u603b\u4e4b\u8fd9\u7bc7\u6587\u7ae0\u4f5c\u8005\u5229\u7528\u78f7\u9178\u5316\u916a\u6c28\u9178\u7684\u8d85\u5206\u5b50\u6750\u6599\uff0c\u53d1\u73b0\u4e86\u8f83\u9ad8\u7ed3\u5408\u529b\u7684\u78f7\u9178\u5316\u916a\u6c28\u9178\u7ed3\u5408\u80bd\u3002<\/strong><\/section>\n

 <\/p>\n

\u672c\u6587\u4f5c\u8005\uff1aXWD<\/p>\n

\u8d23\u4efb\u7f16\u8f91\uff1aLDY<\/p>\n

\u6587\u7ae0\u94fe\u63a5\uff1ahttps:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2022\/sc\/d1sc04420f<\/p>\n

\u539f\u6587\u5f15\u7528\uff1aDOI\uff1ahttps:\/\/doi.org\/10.1039\/D1SC04420F<\/p>\n","protected":false},"excerpt":{"rendered":"

\u5206\u4eab\u4e00\u7bc7\u53d1\u8868\u5728chemical Science\u4e0a\u7684\u6587\u7ae0\uff0c\u9898\u76ee\u4e3a\u201cDiscovery of phosphotyr […]<\/p>\n","protected":false},"author":326,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[],"class_list":["post-49219","post","type-post","status-publish","format-standard","hentry","category-tuijianyuedu"],"_links":{"self":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/49219","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/users\/326"}],"replies":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/comments?post=49219"}],"version-history":[{"count":1,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/49219\/revisions"}],"predecessor-version":[{"id":49220,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/49219\/revisions\/49220"}],"wp:attachment":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/media?parent=49219"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/categories?post=49219"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/tags?post=49219"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}