{"id":48806,"date":"2023-08-29T07:53:03","date_gmt":"2023-08-28T23:53:03","guid":{"rendered":"https:\/\/www.chemhui.com\/?p=48806"},"modified":"2023-08-14T07:53:26","modified_gmt":"2023-08-13T23:53:26","slug":"angew-chem-%ef%bc%9a%e5%85%b7%e6%9c%89%e6%8a%97%e8%a1%b0%e8%80%81%e6%95%88%e8%83%bd%e7%9a%84%e7%ba%a7%e8%81%94%e7%ba%b3%e7%b1%b3%e9%85%b6%e7%94%a8%e4%ba%8e%e9%98%b2%e6%b2%bb%e5%8a%a8%e8%84%89","status":"publish","type":"post","link":"http:\/\/www.chemhui.com\/angew-chem-%ef%bc%9a%e5%85%b7%e6%9c%89%e6%8a%97%e8%a1%b0%e8%80%81%e6%95%88%e8%83%bd%e7%9a%84%e7%ba%a7%e8%81%94%e7%ba%b3%e7%b1%b3%e9%85%b6%e7%94%a8%e4%ba%8e%e9%98%b2%e6%b2%bb%e5%8a%a8%e8%84%89\/","title":{"rendered":"Angew. Chem. \uff1a\u5177\u6709\u6297\u8870\u8001\u6548\u80fd\u7684\u7ea7\u8054\u7eb3\u7c73\u9176\u7528\u4e8e\u9632\u6cbb\u52a8\u8109\u7ca5\u6837\u786c\u5316"},"content":{"rendered":"<section>\n<section>\n<section>\n<section>\n<section>\u7ec6\u80de\u8870\u8001\u662f\u4e00\u79cd\u4e0d\u53ef\u9006\u7684\u7ec6\u80de\u5468\u671f\u505c\u6ede\u72b6\u6001\u3002\u5185\u76ae\u7ec6\u80de\u7684\u8870\u8001\u88ab\u8ba4\u4e3a\u662f\u52a8\u8109\u7ca5\u6837\u786c\u5316\u5f62\u6210\u548c\u6210\u719f\u7684\u5173\u952e\u9a71\u52a8\u56e0\u7d20\u3002\u51cf\u7f13\u5185\u76ae\u7ec6\u80de\u8870\u8001\u6709\u671b\u6cbb\u7597\u52a8\u8109\u7ca5\u6837\u786c\u5316\u3002<\/p>\n<p>\u5728\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6591\u5757\u5fae\u73af\u5883\u4e2d\uff0c\u8870\u8001\u7ec6\u80de\u4e0e\u6d3b\u6027\u6c27\uff08ROS\uff09\u76f8\u4e92\u4f5c\u7528\uff0c\u4fc3\u8fdb\u75be\u75c5\u53d1\u5c55\u3002\u8870\u8001\u7ec6\u80de\u4e2d\u9ad8\u6c34\u5e73\u7684ROS\u5bfc\u81f4\u81ea\u8eab\u6297\u6c27\u5316\u9632\u5fa1\u7cfb\u7edf\u88ab\u7834\u574f\uff0c\u5982\u5929\u7136\u6297\u6c27\u5316\u9176SOD\u548cGPx\u8868\u8fbe\u51cf\u5c11\u3002\u8fd9\u4e24\u79cd\u6297\u6c27\u5316\u9176\u90fd\u5df2\u88ab\u8bc1\u660e\u5177\u6709\u6291\u5236\u52a8\u8109\u7ca5\u6837\u786c\u5316\u53d1\u5c55\u7684\u4f5c\u7528\u3002\u4f46\u76ee\u524d\u4e34\u5e8a\u4e0a\u8fd8\u6ca1\u6709\u76f8\u5173\u6297\u8870\u8001\u836f\u7269\u7528\u4e8e\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u9884\u9632\u548c\u6cbb\u7597\u3002\u57fa\u4e8e\u8870\u8001\u7ec6\u80de\u4e2d\u88ab\u7834\u574f\u7684\u6297\u6c27\u5316\u9632\u5fa1\u7cfb\u7edf\u4ee5\u53caROS\u6c34\u5e73\u9ad8\u7684\u7279\u70b9\uff0c\u5357\u4eac\u5927\u5b66\u9b4f\u8f89\u6559\u6388\u8bfe\u9898\u7ec4\u8bbe\u8ba1\u4e86\u4e00\u79cd\u5177\u6709\u6297\u8870\u8001\u548c\u6297\u6c27\u5316\u6d3b\u6027\u7684\u7ea7\u8054\u7eb3\u7c73\u9176\uff0c\u901a\u8fc7\u8865\u7ed9\u7ea7\u8054\u7eb3\u7c73\u9176\uff0c\u6291\u5236\u4e86\u5185\u76ae\u7ec6\u80de\u8870\u8001\uff0c\u6e05\u9664\u4e86\u8fc7\u91cf\u7684ROS\uff0c\u51cf\u7f13\u4e86\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6591\u5757\u7684\u53d1\u5c55\u3002\u8be5\u5de5\u4f5c\u4e3a\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u9632\u6cbb\u63d0\u4f9b\u4e86\u65b0\u7684\u601d\u8def\u548c\u65b9\u6cd5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p>&nbsp;<\/p>\n<section>\n<section><\/section>\n<\/section>\n<p>&nbsp;<\/p>\n<section><img decoding=\"async\" title=\"1\" src=\"http:\/\/9794.seohost.cn\/storage\/9794\/article\/20230807\/1691377570191471.png\" alt=\"1\" \/><\/section>\n<section>\u56fe1. \u7ea7\u8054\u7eb3\u7c73\u9176MSe<sub>1\u00a0<\/sub>\u6cbb\u7597\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u4f5c\u7528\u673a\u5236\u793a\u610f\u56fe<\/p>\n<\/section>\n<section>\n<section>\n<section>\n<section>\n<section>\u4f5c\u8005\u901a\u8fc7\u5728\u5177\u6709SOD\u9176\u6d3b\u6027\u7684MIL-53(Fe)-NO<sub>2<\/sub>\u4e2d\u63ba\u5165\u4e0d\u540c\u91cf\u7684Se\uff08\u5177\u6709GPx\u9176\u6d3b\u6027\uff09\uff0c\u6210\u529f\u5408\u6210\u4e86\u6574\u5408SOD\u548cGPx\u6d3b\u6027\u7684\u7ea7\u8054\u7eb3\u7c73\u9176MSe<sub>x<\/sub>\u3002\u901a\u8fc7\u6bd4\u8f83\u4f53\u5916\u6297\u6c27\u5316\u6d3b\u6027\u3001\u6297\u7ec6\u80de\u8870\u8001\u80fd\u529b\u3001\u7ec6\u80de\u4fdd\u62a4\u80fd\u529b\u4ee5\u53ca\u751f\u7269\u5b89\u5168\u6027\uff0c\u7b5b\u9009\u51fa\u4e86\u6700\u4f18\u7684MSe<sub>1<\/sub>\u7528\u4e8e\u540e\u7eed\u5b9e\u9a8c\u3002\u5728\u4f53\u5916\u7ec6\u80de\u5b9e\u9a8c\u4e2d\uff0c\u7ea7\u8054\u7eb3\u7c73\u9176MSe<sub>1<\/sub>\u663e\u793a\u51fa\u826f\u597d\u7684\u6297\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u8870\u8001\u80fd\u529b\uff0c\u4ee5\u53ca\u4f18\u5f02\u7684ROS\u6e05\u9664\u80fd\u529b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section><\/section>\n<\/section>\n<section><img decoding=\"async\" title=\"2\" src=\"http:\/\/9794.seohost.cn\/storage\/9794\/article\/20230807\/1691377580511013.png\" alt=\"2\" \/><\/section>\n<section>\u56fe2. MSe<sub>1<\/sub>\u4f53\u5916\u6297\u7ec6\u80de\u8870\u8001\u548c\u6e05\u9664ROS\u7684\u80fd\u529b<\/p>\n<\/section>\n<section><img decoding=\"async\" title=\"3\" src=\"http:\/\/9794.seohost.cn\/storage\/9794\/article\/20230807\/1691377589124008.png\" alt=\"3\" \/><\/section>\n<section>\u56fe3. MSe<sub>1<\/sub>\u4f53\u5916\u6291\u5236\u6ce1\u6cab\u7ec6\u80de\u5f62\u6210\u7684\u80fd\u529b<\/p>\n<\/section>\n<section>\n<section>\n<section>\n<section>\n<section>\u5728\u52a8\u8109\u7ca5\u6837\u786c\u5316\u5f62\u6210\u8fc7\u7a0b\u4e2d\uff0c\u5de8\u566c\u7ec6\u80de\u548c\u5185\u76ae\u7ec6\u80de\u541e\u566c\u7531\u9ad8\u6c34\u5e73ROS\u8bf1\u5bfc\u5f62\u6210\u7684\u6c27\u5316\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u540e\u5f62\u6210\u6ce1\u6cab\u7ec6\u80de\uff0c\u8fdb\u800c\u52a0\u901f\u6591\u5757\u7684\u5f62\u6210\u3002\u4f53\u5916\u5b9e\u9a8c\u8868\u660e\uff0c\u7ea7\u8054\u7eb3\u7c73\u9176MSe<sub>1<\/sub>\u53ef\u4ee5\u901a\u8fc7\u6291\u5236\u7ec6\u80de\u541e\u566c\u6c27\u5316\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\uff0c\u51cf\u5c11\u6ce1\u6cab\u7ec6\u80de\u7684\u5f62\u6210\uff0c\u6709\u5229\u4e8e\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u9632\u6cbb\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section><\/section>\n<\/section>\n<section><img decoding=\"async\" title=\"4\" src=\"http:\/\/9794.seohost.cn\/storage\/9794\/article\/20230807\/1691377599269134.png\" alt=\"4\" \/><\/section>\n<section>\u56fe4. MSe<sub>1<\/sub>\u5bf9ApoE-\/-\u5c0f\u9f20\u7684\u6cbb\u7597\u6548\u679c<\/p>\n<\/section>\n<section>\n<section>\n<section>\n<section>\n<section>\u7ecf\u8fc7\u7cfb\u7edf\u6027\u8bc4\u4f30MSe<sub>1<\/sub>\u7ea7\u8054\u7eb3\u7c73\u9176\u5bf9\u4e8eApoE<sup>-\/-<\/sup>\u5c0f\u9f20\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u6cbb\u7597\u6548\u679c\uff0c\u7ed3\u679c\u663e\u793a\uff0cMSe<sub>1<\/sub>\u8f83\u5355\u4e00\u6d3b\u6027\u7684Se\u548cMIL-53(Fe)-NO<sub>2<\/sub>\u5177\u6709\u66f4\u597d\u7684\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u6cbb\u7597\u4f5c\u7528\u3002\u7ea7\u8054\u7eb3\u7c73\u9176\u901a\u8fc7\u53d1\u6325\u6297\u7ec6\u80de\u8870\u8001\u4ee5\u53ca\u6297\u6c27\u5316\u5e94\u6fc0\u7684\u80fd\u529b\uff0c\u8fbe\u5230\u4e86\u7a33\u5b9a\u6591\u5757\u3001\u51cf\u5c11\u8870\u8001\u7ec6\u80de\u548c\u7ec4\u7ec7\u6c27\u5316\u5e94\u6fc0\u7684\u6548\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section><\/section>\n<\/section>\n<section><img decoding=\"async\" title=\"0\" src=\"http:\/\/9794.seohost.cn\/storage\/9794\/article\/20230807\/1691377611815029.png\" alt=\"0\" \/><\/section>\n<section>\u56fe5. \u5bf9MSe<sub>1\u00a0<\/sub>\u6cbb\u7597\u540e\u7684ApoE<sup>-\/-<\/sup>\u5c0f\u9f20\u8fdb\u884c\u6297\u8870\u8001\u548c\u6297\u6c27\u5316\u7597\u6548\u8bc4\u4f30<\/p>\n<\/section>\n<section>\n<section>\n<section>\n<section><strong>\u8bba<\/strong><strong>\u6587\u4fe1\u606f<\/strong><\/p>\n<\/section>\n<\/section>\n<section>\n<section><\/section>\n<\/section>\n<section>\n<section>\n<section>\n<section>\n<section><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>Integrated Cascade Nanozymes with Antisenescence Activities for Atherosclerosis Therapy<\/p>\n<p>Wanling Liu,\u00a0Yihong Zhang,\u00a0Gen Wei,\u00a0Minxuan Zhang,\u00a0Tong Li,\u00a0Quanyi Liu,\u00a0Zijun Zhou,\u00a0Yan Du,\u00a0Prof.\u2005Dr. Hui Wei<\/p>\n<p>\u6587\u7ae0\u7684\u7b2c\u4e00\u4f5c\u8005\u662f\u5357\u4eac\u5927\u5b66\u7684\u535a\u58eb\u7814\u7a76\u751f\u5218\u5b9b\u7075\u548c\u535a\u58eb\u7814\u7a76\u751f\u5f20\u76ca\u5b8f\u3002<\/p>\n<p><em>Angewandte Chemie International Edition<\/em><\/p>\n<p>DOI:\u00a010.1002\/anie.202304465<\/p>\n<\/section>\n<\/section>\n<\/section>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7ec6\u80de\u8870\u8001\u662f\u4e00\u79cd\u4e0d\u53ef\u9006\u7684\u7ec6\u80de\u5468\u671f\u505c\u6ede\u72b6\u6001\u3002\u5185\u76ae\u7ec6\u80de\u7684\u8870\u8001\u88ab\u8ba4\u4e3a\u662f\u52a8\u8109\u7ca5\u6837\u786c\u5316\u5f62\u6210\u548c\u6210\u719f\u7684\u5173\u952e\u9a71\u52a8\u56e0\u7d20\u3002\u51cf\u7f13\u5185\u76ae\u7ec6 [&hellip;]<\/p>\n","protected":false},"author":326,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[],"class_list":["post-48806","post","type-post","status-publish","format-standard","hentry","category-tuijianyuedu"],"_links":{"self":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/48806","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/users\/326"}],"replies":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/comments?post=48806"}],"version-history":[{"count":1,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/48806\/revisions"}],"predecessor-version":[{"id":48807,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/48806\/revisions\/48807"}],"wp:attachment":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/media?parent=48806"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/categories?post=48806"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/tags?post=48806"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}