{"id":48514,"date":"2023-07-24T08:00:49","date_gmt":"2023-07-24T00:00:49","guid":{"rendered":"https:\/\/www.chemhui.com\/?p=48514"},"modified":"2023-07-07T10:01:16","modified_gmt":"2023-07-07T02:01:16","slug":"chembiochem%ef%bc%9acgas-sting%e4%bf%a1%e5%8f%b7%e8%bd%ac%e5%af%bc%e4%b8%ad%e7%9a%84%e7%9b%b8%e5%88%86%e7%a6%bb%e8%bf%87%e7%a8%8b%e5%8f%8a%e5%85%b6%e7%9b%b8%e5%85%b3%e5%8a%9f%e8%83%bd","status":"publish","type":"post","link":"http:\/\/www.chemhui.com\/chembiochem%ef%bc%9acgas-sting%e4%bf%a1%e5%8f%b7%e8%bd%ac%e5%af%bc%e4%b8%ad%e7%9a%84%e7%9b%b8%e5%88%86%e7%a6%bb%e8%bf%87%e7%a8%8b%e5%8f%8a%e5%85%b6%e7%9b%b8%e5%85%b3%e5%8a%9f%e8%83%bd\/","title":{"rendered":"ChemBioChem\uff1acGAS-STING\u4fe1\u53f7\u8f6c\u5bfc\u4e2d\u7684\u76f8\u5206\u79bb\u8fc7\u7a0b\u53ca\u5176\u76f8\u5173\u529f\u80fd"},"content":{"rendered":"
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\u5728\u7ec6\u80de\u7684\u56fa\u6709\u514d\u75ab\u7cfb\u7edf\u4e2d\uff0c\u73af\u72b6GMP-AMP\u5408\u6210\u9176\uff08cGAS\uff09\u662f\u80de\u8d28\u4e2d\u7279\u5f02\u6027\u611f\u77e5\u5916\u6e90DNA\u7684\u6838\u9178\u611f\u53d7\u5668\uff0c\u5b83\u80fd\u7279\u5f02\u6027\u8bc6\u522b\u591a\u79cd\u6765\u6e90\u7684dsDNA\uff08\u5185\u6e90\u6027dsDNA\uff1a\u6b7b\u7ec6\u80de\u3001\u7ebf\u7c92\u4f53DNA\uff1b\u5916\u6e90\u6027\uff1aDNA\u75c5\u6bd2\u3001\u7ec6\u83cc\u7b49\uff09\u3002\u5f53cGAS\u4e0edsDNA\u7ed3\u5408\u540e\uff0ccGAS\u86cb\u767d\u4f1a\u53d1\u751f\u6784\u8c61\u53d8\u5316\u5e76\u66b4\u9732\u51fa\u50ac\u5316\u4f4d\u70b9\uff0c\u968f\u540e\u50ac\u5316ATP\u3001GTP\u5f62\u62102\u2019, 3\u2019-cGAMP\uff082\u2019, 3\u2019-cyclic GMP-AMP\uff09\uff0c\u8fdb\u800c\u542f\u52a8\u4e0b\u6e38\u4fe1\u53f7\u8f6c\u5bfc\u8fc7\u7a0b\uff0c\u6700\u7ec8\u4fc3\u8fdbI\u578b\u5e72\u6270\u7d20\uff08interferon-I, IFN-I\uff09\u4e0e\u5176\u4ed6\u708e\u75c7\u56e0\u5b50\u7684\u8868\u8fbe\uff0ccGAS-STING\u4fe1\u53f7\u8f6c\u5bfc\u8fc7\u7a0b\u4e2d\u5f62\u6210\u7684\u51dd\u805a\u4f53\u80fd\u591f\u8c03\u8282\u56fa\u6709\u514d\u75ab\u53cd\u5e94\u7684\u6fc0\u6d3b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u968f\u7740\u5bf9cGAS-STING\u901a\u8def\u4e2d\u751f\u7269\u5927\u5206\u5b50\u51dd\u805a\u4f53\u5f62\u6210\u673a\u5236\u53ca\u76f8\u5173\u529f\u80fd\u7684\u4e0d\u65ad\u7814\u7a76\uff0c\u8fdb\u4e00\u6b65\u4fc3\u8fdb\u4e86\u7814\u7a76\u4eba\u5458\u5bf9\u591a\u79cd\u75be\u75c5\u7684\u8ba4\u8bc6\uff0c\u540c\u65f6\u4e3a\u8bb8\u591a\u75be\u75c5\u5f00\u53d1\u65b0\u7684\u6cbb\u7597\u65b9\u6cd5\u63d0\u4f9b\u4e86\u53ef\u80fd\u3002\u56e0\u6b64\uff0c\u9776\u5411cGAS-STING\u901a\u8def\u4e2d\u5f62\u6210\u7684\u51dd\u805a\u4f53\u5e76\u8c03\u63a7\u5176LLPS\u8fc7\u7a0b\u503c\u5f97\u6df1\u5165\u7814\u7a76\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Phase Separation in cGAS-STING Signaling: Cytosolic DNA Sensing and Regulatory Functions<\/p>\n

Caixia Liu,\u00a0Jingyi Yang,\u00a0Jiaxin Zheng,\u00a0Jianmian Fu,\u00a0Prof.\u2005Dr. Weisi Wang,\u00a0Prof.\u2005Dr. Liping Duan,\u00a0Prof.\u2005Dr. Xuhong Qian,\u00a0Prof.\u2005Dr. Yangyang Yang<\/p>\n

ChemBioChem<\/em><\/p>\n

DOI:\u00a010.1002\/cbic.202300147<\/p>\n<\/section>\n<\/section>\n<\/section>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

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