{"id":48154,"date":"2023-06-06T08:19:27","date_gmt":"2023-06-06T00:19:27","guid":{"rendered":"https:\/\/www.chemhui.com\/?p=48154"},"modified":"2023-05-22T10:20:40","modified_gmt":"2023-05-22T02:20:40","slug":"angew-chem-%ef%bc%9a%e9%92%b4%e5%82%ac%e5%8c%96%ce%b1%ce%b2-%e4%ba%8c%e6%b0%98%e4%bb%a3%ce%b1-%e6%b0%a8%e5%9f%ba%e9%85%b8%e7%9a%84%e4%b8%8d%e5%af%b9%e7%a7%b0%e5%90%88%e6%88%90","status":"publish","type":"post","link":"http:\/\/www.chemhui.com\/angew-chem-%ef%bc%9a%e9%92%b4%e5%82%ac%e5%8c%96%ce%b1%ce%b2-%e4%ba%8c%e6%b0%98%e4%bb%a3%ce%b1-%e6%b0%a8%e5%9f%ba%e9%85%b8%e7%9a%84%e4%b8%8d%e5%af%b9%e7%a7%b0%e5%90%88%e6%88%90\/","title":{"rendered":"Angew. Chem. \uff1a\u94b4\u50ac\u5316\u03b1,\u03b2-\u4e8c\u6c18\u4ee3\u03b1-\u6c28\u57fa\u9178\u7684\u4e0d\u5bf9\u79f0\u5408\u6210"},"content":{"rendered":"<section>\n<section>\n<section>\n<section>\n<section>\u6c18\uff08deuterium\uff09\u662f\u6c22\uff08H\uff09\u7684\u4e00\u79cd\u7a33\u5b9a\u540c\u4f4d\u7d20\uff0c\u4e5f\u79f0\u4e3a\u91cd\u6c22\uff0c\u5143\u7d20\u7b26\u53f7\u4e3aD\u6216<sup>2<\/sup>H\u3002\u836f\u7269\u5206\u5b50\u7684\u4ee3\u8c22\u4f4d\u70b9\u5f15\u5165\u6c18\u539f\u5b50\uff0c\u80fd\u51cf\u7f13\u751a\u81f3\u963b\u6b62C-D\u952e\u65ad\u88c2\u3001\u6539\u53d8\u836f\u7269\u4ee3\u8c22\u901f\u7387\u6216\u4ee3\u8c22\u6bd2\u6027\u3001\u51cf\u5c11\u6709\u6bd2\u4ee3\u8c22\u4ea7\u7269\u3001\u63d0\u9ad8\u4ee3\u8c22\u7a33\u5b9a\u6027\u3001\u5ef6\u957f\u751f\u7269\u534a\u8870\u671f\uff0c\u4ece\u800c\u63d0\u9ad8\u836f\u7269\u7684\u5b89\u5168\u6027\u3001\u7597\u6548\u548c\u8010\u53d7\u6027\u3002\u56e0\u6b64\uff0c\u836f\u7269\u5206\u5b50\u7684\u6c18\u6807\u8bb0\u88ab\u8ba4\u4e3a\u662f\u4e00\u79cd\u7b80\u5355\u4e14\u6781\u5176\u6709\u6548\u7684\u836f\u7269\u7814\u53d1\u7b56\u7565\uff0c\u76f8\u5173\u5408\u6210\u65b9\u6cd5\u7814\u7a76\u4ea6\u9010\u6e10\u6210\u4e3a\u65b0\u836f\u7814\u53d1\u7684\u70ed\u95e8\u9886\u57df\u3002<\/p>\n<p>\u8fd1\u65e5\uff0c\u897f\u5357\u5927\u5b66\u836f\u5b66\u9662\u79e6\u7eea\u8363\u6559\u6388\u8bfe\u9898\u7ec4\u548c\u5317\u4eac\u5927\u5b66\u6df1\u5733\u7814\u7a76\u9662\u5468\u5efa\u8363\u7814\u7a76\u5458\u8bfe\u9898\u7ec4\u5408\u4f5c\uff0c\u6210\u529f\u5b9e\u73b0\u4e86\u94b4\u50ac\u5316\u76842-\u6c28\u57fa\u4e19\u70ef\u9178\u916f\u7684\u4e0d\u5bf9\u79f0\u6c18\u5316\u53cd\u5e94\uff0c\u6784\u7b51\u4e86\u4e00\u7cfb\u5217\u91cd\u8981\u7684\u975e\u5929\u7136\u03b1,\u03b2-\u4e8c\u6c18\u4ee3\u7684\u03b1-\u6c28\u57fa\u9178\u884d\u751f\u7269\u3002\u8be5\u4f53\u7cfb\u5177\u6709\u5f88\u597d\u7684\u4ea7\u7387\u3001\u5bf9\u6620\u9009\u62e9\u6027\u3001\u6c18\u6807\u8bb0\u7387\u4ee5\u53ca\u5e7f\u6cdb\u7684\u5e95\u7269\u8303\u56f4\u3002\u8be5\u7b56\u7565\u4ee5\u5ec9\u4ef7\u3001\u5b89\u5168\u7684\u6c18\u4ee3\u7532\u9187\u4f5c\u4e3a\u6c18\u6e90\uff0c\u53d6\u4ee3\u4e86\u4ef7\u683c\u6602\u8d35\u4e14\u5371\u9669\u7684\u9ad8\u538b\u6c18\u6c14\uff08\u56fe1\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p>&nbsp;<\/p>\n<section>\n<section><\/section>\n<\/section>\n<p>&nbsp;<\/p>\n<section><img decoding=\"async\" title=\"1\" src=\"http:\/\/9794.seohost.cn\/storage\/9794\/article\/20230510\/1683687267677416.png\" alt=\"1\" \/><\/section>\n<section>\u56fe1 \u94b4\u50ac\u5316\u76842-\u6c28\u57fa\u4e19\u70ef\u9178\u916f\u7684\u4e0d\u5bf9\u79f0\u6c18\u5316\u53cd\u5e94<\/p>\n<\/section>\n<section>\n<section>\n<section>\n<section>\n<section>\u6b64\u5916\uff0c\u4f5c\u8005\u5c06\u5176\u5e94\u7528\u4e00\u7cfb\u5217\u9187\u7c7b\u836f\u7269\u53ca\u5929\u7136\u4ea7\u7269\u7684\u540e\u671f\u6c18\u6807\u8bb0\u4fee\u9970\uff08\u56fe2\uff09\u3002\u7ed3\u679c\u663e\u793a\uff0c\u836f\u7269\u53ca\u5929\u7136\u4ea7\u7269\u5206\u5b50\u7684\u4e0d\u9971\u548c\u952e\u548c\u548c\u624b\u6027\u4e2d\u5fc3\u5bf9\u8be5\u6c18\u6807\u8bb0\u65b9\u6cd5\u4e0d\u4ea7\u751f\u5f71\u54cd\uff0c\u6240\u6709\u5e95\u7269\u5747\u80fd\u4ee5\u9ad8\u4ea7\u7387\u3001\u9ad8\u5bf9\u6620\u9009\u62e9\u6027\u6216\u975e\u5bf9\u6620\u9009\u62e9\u6027\u4ee5\u53ca\u9ad8\u6c18\u4ee3\u7387\u5f97\u5230\u76f8\u5e94\u7684\u6c18\u5316\u4ea7\u7269\u3002\u5bf9\u7167\u5b9e\u9a8c\uff08(S,S)-QuinoxP*\u4f5c\u4e3a\u914d\u4f53\uff09\u7ed3\u679c\u663e\u793a\uff0c\u914d\u4f53\u7684\u7acb\u4f53\u6784\u578b\u5bf9\u65b0\u624b\u6027\u4e2d\u5fc3\u7684\u7acb\u4f53\u9009\u62e9\u6027\u63a7\u5236\u8d77\u5230\u51b3\u5b9a\u6027\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section><\/section>\n<\/section>\n<section><img decoding=\"async\" title=\"2\" src=\"http:\/\/9794.seohost.cn\/storage\/9794\/article\/20230510\/1683687274804054.png\" alt=\"2\" \/><\/section>\n<section>\u56fe2 \u9187\u7c7b\u836f\u7269\u5206\u5b50\u6216\u5929\u7136\u4ea7\u7269\u7684\u8131\u6c22\u6c28\u57fa\u9178\u916f\u5e95\u7269\u8303\u56f4<\/p>\n<\/section>\n<section>\n<section>\n<section>\n<section>\n<section>\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u4f5c\u8005\u8fdb\u884c\u4e86\u4e00\u7cfb\u5217\u6c18\u4ee3\u836f\u7269\u5408\u6210\u5e94\u7528\u63a2\u7d22\uff08\u56fe3\uff09\u30024a\u7ecfDIBAL-H\u8fd8\u539f\u53ef\u4ee5\u5f97\u5230(R)-7a\uff0c\u5b83\u662fnostocyclopeptide A2-d<sub>2<\/sub>\u7684\u5408\u6210\u524d\u4f53\uff1b4a\u7ecf\u6c34\u89e3\u540e\u4e0e\u591a\u805a\u7532\u919b\u7f29\u5408\u53ef\u4ee5\u5f97\u5230\u6c18\u4ee3\u56db\u6c22\u5f02\u55b9\u5549(R)-7b\uff0c\u5b83\u662f\u6c18\u4ee3\u86cb\u767d\u9176\u4f53\u6291\u5236\u5242\u7684\u5408\u6210\u524d\u4f53\uff1bent-4a\u7ecf\u6c34\u89e3\u540e\u4e0e\u5421\u55ea-2-\u7fa7\u9178\u7f29\u5408\u53ef\u4ee5\u5f97\u52307d\uff0c\u5b83\u662f\u6c18\u4ee3\u787c\u66ff\u4f50\u7c73\u7684\u5408\u6210\u524d\u4f53\uff1b7c\u901a\u8fc7\u7f29\u5408\u548c\u916f\u6c34\u89e3\u80fd\u88ab\u8f6c\u5316\u4e3a\u964d\u7cd6\u836f\u7269\u6c18\u4ee3\u90a3\u683c\u5217\u59487e\uff1b4a\u7ecfLiBH<sub>4<\/sub>\u8fd8\u539f\u53ef\u4ee5\u5f97\u5230(R)-7f\uff0c\u5b83\u53ef\u7ee7\u7eed\u88ab\u8f6c\u5316\u4e3a\u6cbb\u7597\u6210\u4eba\u53d1\u4f5c\u6027\u7761\u75c5\u836f\u7269Solriamfetol-d<sub>2<\/sub>\u3002\u53e6\u5916\uff0c\u4ee53z\u4e3a\u5e95\u7269\u5728\u6807\u51c6\u6761\u4ef6\u4e0b\u8fdb\u884c\u4e0d\u5bf9\u79f0\u6c18\u5316\u53ef\u4ee5\u5f97\u5230(S)-7h\uff0c\u540e\u8005\u7ecf\u9178\u6c34\u89e3\u53ef\u4ee5\u5f97\u5230\u6297\u5e15\u91d1\u68ee\u75c5\u836f\u7269L-DOPA-d<sub>2<\/sub>\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section><\/section>\n<\/section>\n<section><img decoding=\"async\" title=\"3\" src=\"http:\/\/9794.seohost.cn\/storage\/9794\/article\/20230510\/1683687292549572.png\" alt=\"3\" \/><\/section>\n<section>\u56fe3 \u5408\u6210\u5e94\u7528\u63a2\u7d22<\/p>\n<\/section>\n<section>\n<section>\n<section>\n<section><strong>\u8bba<\/strong><strong>\u6587\u4fe1\u606f<\/strong><\/p>\n<\/section>\n<\/section>\n<section>\n<section><\/section>\n<\/section>\n<section>\n<section>\n<section>\n<section>\n<section><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>Cobalt-Catalyzed Asymmetric Deuteration of \u03b1-Amidoacrylates for Stereoselective Synthesis of \u03b1,\u03b2-Dideuterated \u03b1-Amino Acids<\/p>\n<p>Aibo Li,\u00a0Xinjian Song,\u00a0Prof.\u2005Dr. Qiao Ren,\u00a0Peiwang Bao,\u00a0Xinyu Long,\u00a0Fuli Huang,\u00a0Prof.\u2005Dr. Lvjiang Yuan,\u00a0Prof.\u2005Dr. Jianrong Steve Zhou,\u00a0Prof.\u2005Dr. Xurong Qin<\/p>\n<p><em>Angewandte Chemie International Edition<\/em><\/p>\n<p>DOI:\u00a010.1002\/anie.202301091<\/p>\n<\/section>\n<\/section>\n<\/section>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6c18\uff08deuterium\uff09\u662f\u6c22\uff08H\uff09\u7684\u4e00\u79cd\u7a33\u5b9a\u540c\u4f4d\u7d20\uff0c\u4e5f\u79f0\u4e3a\u91cd\u6c22\uff0c\u5143\u7d20\u7b26\u53f7\u4e3aD\u62162H\u3002\u836f\u7269\u5206\u5b50\u7684\u4ee3\u8c22\u4f4d\u70b9\u5f15\u5165\u6c18\u539f [&hellip;]<\/p>\n","protected":false},"author":326,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[],"class_list":["post-48154","post","type-post","status-publish","format-standard","hentry","category-tuijianyuedu"],"_links":{"self":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/48154","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/users\/326"}],"replies":[{"embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/comments?post=48154"}],"version-history":[{"count":1,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/48154\/revisions"}],"predecessor-version":[{"id":48155,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/posts\/48154\/revisions\/48155"}],"wp:attachment":[{"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/media?parent=48154"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/categories?post=48154"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.chemhui.com\/wp-json\/wp\/v2\/tags?post=48154"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}